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Biomedical subjects

W Müller

Publications and source records attributed to W Müller.

At least 901 records · Page 50Linked to original sources
PubMed1976

[Topgraphical classification of craniopharyngioma].

Squamous cell nests of Erdheim have been observed along the lateral blood vessels to the adenohypophysis in 4 cases. Their developmental origin and topographical distribution correlate with the sites in which craniopharyngiomas are found. The theory of dysontogenic origin of cranopharyngiomas is supported by these findings. Metaplasia of cells of the adenohypophysis is not considered to be a likely cause of craniopharyngioma formation.

Adolescent↗
PubMed1976

Effect of yttrium 90 on experimental allergic arthritis in rabbits.

Seventeen rabbits were immunized with complete Freund's adjuvant and bovine serum albumin by the method of Dumonde and Glynn (1962), as modified by Cooke and Jasin (1972). Fifteen weeks after allergic arthritis developed in the knee joint, 8 animals were given an injection of 20 muCi yttrium 90 (90Y) into the left joint cavity; 7 were injected with 400 muCi. The animals were sacrificed at 2, 4, 8, 12, and 16 weeks and at 6 and 12 months after the injection. The right knee joint served as control for assessment of untreated allergic arthritis. Morphological control of the severity of the arthritis was provided by sacrificing 2 uninjected animals 13 weeks after immunization.

Animals↗
PubMed1976

Immunotherapy with levamisole in rheumatic diseases.

The immuno-modulatory effect of Levamisole in the treatment of rheumatic diseases was studied in an open trial. Nine patients with theumatoid arthritis (RA), 13 with ankylosing spondylitis (AS) and one with Reiter's syndrome (RS) were treated initially with 150 mg Levmisole daily for 4 weeks, then intermittently 3 days a week. Significant clinical improvement was observed in 7 out of 9 patients with RA, in 4 out of 13 patients with AS, and in the one patient with RS. An increased skin sensitivity to a panel of antigens was noted in 3 out of 9 RA patients and in 6 out of 13 AS patients. A fall in rheumatoid factor titre was observed in 2 out of 5 patients with seropositive RA. No development of other auto-antibodies was observed. No significant changes in the absolute lymphocyte counts either of the total counts or of the T, B, and null cell counts, were noted. Drug-related adverse reactions were seen in 13 patients, mostly allergic skin rash which required a short interruption in therapy. Severe leucopenia was observed in 2 patients, whereupon therapy was definitely withdrawn. Levamisole seems to have a definite beneficial effect on RA and a possible effect on AS and RS. Severe adverse reactions, mostly on the haemopoietic system, demonstrated some potential hazardous complications of the drug and required physical and laboratory examinations at short intervals.

Adult↗
PubMed1976

[Action of several respiration inhibitors on the tetramethyl-p-phenyldiamine short-circuit pathway in nonphosphorylating electron transport particles in the bovine heart].

Non-phosphorylating electron transfer particles from beef heart according to CRANE et al. possess the ability to oxidize succinate via the artificial TMPD bypass of the respiratory chain. The respiratory inhibitors TTFA, carboxin, tridemorph and the inhibitory protein RF from rabbit reticulocytes act both on the normal succinate oxidase and on the bypass. The presence of antimycin A diminishes the inhibition of carboxin on the bypass, likely by way of the increase of the degree of reduction in the iron-sulphur proteins. The inhibition by an isatin-beta-isothiosemicarbazone acting on the complex III of the succinate oxidase system is relieved by TMPD analogous to antimycin A.

Animals↗
PubMed1976

The effect of Levamisole on peripheral blood lymphocyte subpopulations in patients with rheumatoid arthritis and ankylosing spondylitis.

Although Levamisole, an antihelmintic drug, has shown to have some modulatory effect on the immune response in clinical trials and experimental models, its mode of action remains obscure. In a group of fifteen patients with rheumatoid arthritis and ankylosing spondylitis receiving Levamisole on an intermittant regime, simultaneous determinations of the lymphocyte subpopulations were made prior to Levamisole administration and 3 months thereafter. No significant changes were observed either in the absolute or in the relative number of T- and B-cell populations, while a statistically significant reduction was found in the "null" cells. These findings suggest that the immune potentiating effect of Levamisole may at least partially be due to a maturation process of the "null" cells.

Arthritis, Rheumatoid↗