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Biomedical subjects

W Müller

Publications and source records attributed to W Müller.

At least 883 records · Page 49Linked to original sources
PubMed1977

[Capsular arthroplasty of the elbow joint for the treatment of recurrent dislocation. Personal results in comparison with case reports in literature. Indication--methods--after care].

Four cases of recurrent dislocation of the elbow joint are reported. Instability of the postero-lateral ligaments were found in all patients, both clinically and during operation. In one case there was also instability of the medial ligament. Lateral instability is regarded as the primary lesion responsible for recurrent dislocation. Intraarticular pathological lesions such as osteochondral fractures were also diagnosed in our patients. All were treated by a capsuloligamentous repair as proposed by Osborne and Cotterill [8]. Based on follow-ups of 2 to nearly 5 years no recurrences were seen. The patients were free of pain with a nearly full range of motion. Considering the results reported in the literature of cases treated by the same method, the authors are convinced that the operation repairs the essential lesion.

Arm Injuries↗
PubMed1976

[Psychsomatic aspects of rheumatic, especially soft tissue rheumatic diseases].

Rheumatic diseases may be connected to varying degrees with psychic factors. On the one hand, rheumatic diseases may produce psychic reactions, while on the other hand rheumatic symptoms--especially in extra-articular rheumatism--may be induced by psychosomatic hysteric pararheumatic diseases and depressive mechanisms. Special reference is made to psychosomatically induced extra-articular rheumatic diseases in which not only the complex genesis but also the clinical symptomatology are discussed. During therapy more attention should be directed to psychic factors than in the past, as only an intensive psycho and/or psychopharmacotherapy can influence the disease.

Adult↗
PubMed1976

Subsarcolemmal mitochondria and capillarization of soleus muscle fibers in young rats subjected to an endurance training. A morphometric study of semithin sections.

Rats, 6 weeks old, were subjected to a program of endurance running for 3, 6 and 12 weeks. 0.5 to 0.8 mum thick sections of Epon embedded soleus muscles were studied with morphometric methods. In cross-sections the area occupied by subsarcolemmal mitochondria was independent of the age, but was 53% higher after 12 weeks of training. The mean depth of the zones with subsarcolemmal mitochondria increased only 15% to about 0.9 mum. Thus, the subsarcolemmal mitochondria showed a pronounced spreading at the muscle fiber surface in trained muscles.-The number of capillaries per fiber decreased slightly in controls and increased not significantly in trained muscles. It is concluded that the subsarcolemmal mitochondria supply the energy for the active transport of metabolites through the sarcolemma in oxidative muscle fibers, and that they are the limiting factor for endurance performance of the soleus muscle fibers because the changes in the capillarization were only small. It is suggested that the subsarcolemmal and the interfibrillar mitochondria have different functions and may therefore represent different types of mitochondria which can be distinguished by their morphology as well as by their biochemical properties.

Animals↗
PubMed1976

[The operative treatment of recurrent and simple traumatic dislocations of the elbow by the method of Osborne and Cotterill (author's transl)].

The essential pathological defect causing dislocation of the elbow is failure of the postero-lateral ligamentous and capsular structures. A pocket of the capsule is created into which the head of the radius is received as it slides off its articulation with the humerus. Damage to the osteochondral surface of the radius and capitulum humeri is often significant in recurrent and also simple traumatic dislocations of the elbow joint. An osteochondral fracture may occur in simple dislocation happening but once and predispose for recurrent dislocation. For treatment of recurrent dislocation we prefer the simple method of Osborne and Cotterill because in our opinion it attacks the essential lesion. More complicated techniques such as bone blocks or tendon transfers, are believed to be less effective and unnecessary. Four patients with recurrent dislocation of the elbow joint were treated successfully by this method, based on an follow-ups of from 2 to 4 years. Encouraged by the results we transferred the method to the treatment of simple traumatic dislocations in 10 patients. A follow-up of these patients has shown that an early operation will give satisfactory functional results. In the meanwhile the method of Osborne and Cotterill has become a standard technique for the treatment of osteochondrosis dissecans too by the authors.

Adolescent↗
PubMed1976

[Therapy of inflammatory-rheumatic diseases with levamisol, an immunity modulating substance].

Since cellular and humoral immune mechanisms were shown to be involved in the pathogenesis of rheumatic diseases, efforts have been made to influence these systems therapeutically. Aside from suppression of the immune response, studies have been conducted to evaluate to what extent immunostimulation might be of value in the treatment of rheumatic diseases. Levamisole, chemically a simple synthetic agent recently shown to have immunorestorative capacities in anergic cancer patients, has been administered in several rheumatic diseases. The drug was administered either continuously or intermittently in a daily dose of 150 mg over several months. In about half of the rheumatoid arthritis patients a significant improvement was noted. Beneficial effects and sometimes even dramatic improvement lere observed in some patients with systemic lupus erythematosus, ankylosing spondylitis and Reiter's syndrome. Levamisole did not alter the course of psoriatic arthritis. Significant adverse reactions were leukopenia and allergic skin reactions. Other side effects were mild and did not require interruption of drug intake. The use of levamisole in rheumatic diseases is still experimental, but with accumulating experience it may provide a true improvement in control of rheumatic diseases.

Arthritis↗
PubMed1976

[Demonstration and analysis of immune complexes in rheumatic diseases].

By means of an immunofluorescence technique, immune complexes have been demonstrated in circulating blood leukocytes, in serum and in joint effusions of patients with various rheumatic diseases. Such complexes are present within cell inclusions in about 30% of patients with rheumatoid arthritis (RA). RA patients has immune complexes in serum in 75% of cases and in joint effusions in over 80% of cases. Soluble immune complexes were demonstrated in the serum of about 30% of age-matched patients with degenerative joint disease, while such complexes are present in the serum of only 1.5% of a younger, normal control group. The immune complexes chiefly contain IgG, frequently IgM and only rarely IgA. CO complement component can frequently be demonstrated within such complexes. In RA patients a statistically significant correlation (p less than 0.001) could be established between the presence of soluble immune complexes and erythrocyte sedimentation rate, but no correlation was observed between the presence of such complexes and the Lansbury joint index. The possible pathogenetic role of immune complex clearance by circulating leukocytes in rheumatoid arthritis is discussed.

Antigen-Antibody Complex↗
PubMed1976

[Local treatment of chronic arthritis with radionuclides].

Radiosynoviorthesis plays an important role in local treatment of rheumatoid arthritis. Depending on the size of the joint, radionuclides are used at different depths of penetration. Data from the literature and our own results with 396 treated joints indicate that in 2/3 of cases good therapeutic effects are achieved, e.g. the effect on the local inflammatory process is comparable with surgical synovectomy. This is in agreement with the results of our longterm follow-up of 141 joints after radiosynoviorthesis. As with surgical synovectomy, early synoviorthesis was most successful; however, longterm observations revealed a slight increase in local recurrences. These and primary non-responder cases show a good response to secondary injection of radionuclides. The effect of intraarticular injection of isotopes is possibly due to irradiative action on the inflamed cells, with subsequent fibrosis of the synovium. Side effects of radiosynoviorthesis are rare and generally avoidable. Since late complications cannot be excluded, careful consideration should be given to the indication for radiosynoviorthesis. Radiosynoviorthesis represents an alternative treatment to surgical synovectomy in patients over 40 years of age.

Arthritis↗
PubMed1976

Time dependent effects on contractile properties, fibre population, myosin light chains and enzymes of energy metabolism in intermittently and continuously stimulated fast twitch muscles of the rabbit.

Fast-twitch tibialis anterior and extensor digitorum longus rabbit muscles were subjected to long-term intermittent (8 h daily) or continuous (24 h daily) indirect stimulation with a frequency pattern resembling that of a slow motoneuron. Increases in time to peak of isometric twitch contraction were observed without parallel changes in the pattern of myosin light chains or alterations in the distribution of slow and fast fibres as discernible by the histochemical ATPase reaction. However, changes in the fibre population and in the myosin light chain pattern were observed after intermittent stimulation periods exceeding 40 days or continuous stimulation periods longer than 20 days. Under these conditions even higher increases were found in contraction time. In one animal a complete change in fbire population was observed. In this case myosin light chains of the slow (LCS1, LCS2) and of the fast type (LCf1) were obviously synthetized simultaneously within the same fibre. Early changes in the enzyme activity pattern of energy metabolism indicated a conversion of the fibres including their mitochondrial population. These changes and the earlier reported changes in the sarcoplasmic reticulum are probably responsible for the early changes in contractile properties which occur before the transformation of the myosin.

Adenosine Triphosphatases↗