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Biomedical subjects

W Müller

Publications and source records attributed to W Müller.

At least 847 records · Page 47Linked to original sources
PubMed1978

A combined neurofibroma-granular cell tumor of the middle cranial fossa.

A case of a combined neurofibroma-granular cell tumor in a 52 years old gunsmith is presented. The tumor developed after an intracranial trigeminal nerve operation 25 years previously. The solid tumor in the left middle cranial fossa had displaced and infiltrated the temporal lobe. It had expanded via the optic nerve into the left orbit, and further the apex partis petrosae was destroyed. The neurofibroma part shows histological aspects of malignancy, the granular cell tumor, considering its infiltrating and destructive growth, may be regarded as malignant as well. In intermingling portions of the tumor, transitional types of fiber-like and granular cells are prominent. In the peripheral zone of the tumor apparently reactively proliferated polynuclear astrocytes are seen with occasionally intracytoplasmatic lymphocytes (emperipolesis?). A short review of the literature and the theories concerning the histogenesis of the granular cell tumor is given. Whereas most authors in recent years suggest a Schwann cell origin, based on electron microscopic findings, this intermediate tumor type motivates us to postulate a mesodermal origin of the granular cell tumor. The question of viral influence is discussed briefly.

Aged↗
PubMed1978

Base specific fractionation of double stranded DNA: affinity chromatography on a novel type of adsorbant.

A material suitable for base-pair-specific "affinity chromatography" of double stranded DNA is described. The synthesis of this material involves two successive polymerization reactions yielding solid particles of cross-linked bisacrylamide to which base-pair-specific dyes are covalently attached by spacers of polyacrylamide chains of different length. Materials with immobilized A.T-specific malachite green or G.C-specific phenyl neutral red were used for base-pair-specific fractionation of sheared DNA from bacterial sources, as well as of higher molecular weight Calf thymus DNA or defined fragments of coliphage lambda DNA. The excellent resolving power of this method of "affinity chromatography" of nucleic acids is comparable only to DNA fractionation in buoyant density gradients in the presence of base-pair-specific ligands. A great advantage of this material is its simple handling and its chemical stability, which allows repeated re-use of the same column.

Animals↗
PubMed1978

[Personal method for the surgical treatment of recessed gingiva].

The authors report their experience with a personal technique for the surgical treatment of gingival recessions. Their experience is based on operations upon 35 teeth. To avoid recurrences, the authors perform, on principle, the necessary vestibuloplasty, covering the wound surface with a full-thickness skin graft taken from the cheek, three weeks after the first intervention. The good results obtained permit to recommend this method.

Gingival Diseases↗
PubMed1978

[Treatment of lobar fibroses with retroauricular full thickness skin transplantations].

With a view to optimal treatment results, the reconstruction of the vestibule of the mouth by means of retroauricular full-thickness skin graft constitutes a precious contribution to the therapeutical possibilities. The imperfections of split-thickness skin transplantation are avoided by this method. The procedure is recommended for cases in which it is not possible to cover, after excision of an extended lobar fibrosis, the wound surface with a graft taken from the buccal mucous membrane.

Humans↗
PubMed1978

[Bird-headed-dwarfism. A case report (author's transl)].

The case history and symptoms of a girl aged 12 months are reported suffering from bird-headed-dwarfism or Seckel-Syndrom: low birth weight in spite of prolonged pregnancy, typical "bird-headed-face", mikrocephaly, dwarfism, dystrophy, mental-motoric retardation.

Abnormalities, Multiple↗
PubMed1978

[Heroin-withdrawal-syndrome in the newborn (author's transl)].

A case of a heroin-withdrawal-syndrome is reported. Diagnostic, therapeutic and social aspects of this syndrome are discussed. Newborn infants delivered from mothers addicted to heroin often develop a deprivation syndrome. 40% of these children are small for date babies. Symptoms of deprivation begin after delivery or between the 1st and 4th week of life. Generally the onset of symptoms lies between the 1st and 3rd day of life with irritability, tremor, restlessness, and shrill cry. The degree of illness depends upon mother's last heroin intake. Treatment for drug addicts are tinctura opii (3--5--10 drops orally following 4 hours) and Chlorpromazine (2,2 mg/kg/25 hours orally or i. m.). The mortality rate increases when treatment is missing.

Electroencephalography↗
PubMed1978

[Wound infections in arterial surgery of the lower extremities].

A survey showed that in 764 cases of reconstructive vascular operations of the lower extremities there were 5.14% bland infections, 1.14% were, however, severe. In 78.5% of these infections synthetic materials were used. Autologous venous tissue for bypass or patches showed the lowest risks. In the case of postoperative signs of an infection on an arterial suture, a secondary bypass well in an area of healthy tissue should immediately be attempted to save the limb.

Arterial Occlusive Diseases↗
PubMed1978

Congenital factor V deficiency. A family study.

A 14-month-old girl suffering from a heavy bleeding tendency, caused by a severe isolated congenital factor V deficiency is described. In this study 56 family members were examined. 10 of them had a factor V level ranging 26-60% of the normal--these were classified as heterozygotes. The case histories of the heterozygotes did not reveal a bleeding tendency. The inheritance of this factor V deficiency is autosomal recessive, with varying expressivity in the heterozygotes.

Factor V Deficiency↗
PubMed1978

Biosynthesis of the first component of complement by human and guinea pig peritoneal macrophages: evidence for an independent production of the C1 subunits.

The first component of complement, C1, was produced by human as well as guinea pig macrophages. Supernatants from serum-free cultured macrophage monolayers, tested separately for C1q and C1 activity, showed a ratio of 15:1, respectively, and a different time course of C1q and C1 production, indicating that the subcomponents of C1 are synthesized independently. Heat-inactivated fetal calf or guinea pig serum (2 hr, 56 degrees C), added to the culture medium, were found to be inhibitory for C1 but not for C1q activity, obviously due to still active C1 inhibitor in these sera. De novo synthesis was confirmed by reversible inhibition of C1 and C1q production by cycloheximide (0.5 microgram/ml) and puromycin (1 microgram/ml), by incorporation of radiolabeled amino acids into the C1s subcomponent, and by uptake of incorporated radioactivity by EA, which was sensitive to EDTA. In additional experiments, 2,2'-dipyridyl markedly reduced C1q and also C1 secretion in the supernatants. Inhibition of the prolyl and lysyl hydroxylation and, as a consequence, structural instability of the collagenous region in the C1q molecule, is discussed as the cause of this effect which is analogous to collagen biosynthesis.

2,2'-Dipyridyl↗
PubMed1978

[Prevention of neonatal apnea with theophylline (author's transl)].

To the well known methods for prevention of neonatal apnea like stimulation, CPAP, and mechanical ventilation the treatment with theophylline has been added recently. We studied the efficiency of theophylline therapy in 10 premature infants with apnea. The initial dosage was 6 mg theophylline/kg body-weight, followed by a dosage of 2 mg/kg for the next 12 h. The frequency of apnea thereby was significantly reduced. Only in two cases the heart rate rose above 180/min as a side effect. In no case an additional therapy was necessary.

Apnea↗