Biomedical subjects

W M Murphy

Publications and source records attributed to W M Murphy.

At least 145 records · Page 8Linked to original sources

PubMed1977

Falsely positive urinary cytology: pathologist's error or preclinical cancer?

The reluctance to accept urinary cytology as a diagnostic procedure in urologic cancer has been partially owing to a relatively high incidence of falsely positive results. The recent recognition of bladder cancer as a field change and the identification of urothelial dysplasia support the contention that these cytologic findings represent early neoplasia rather than laboratory errors. Of 64 patients with positive or suspicious urinary cytology short-term histologic confirmation could not be obtained in 10. Of these 10 patients review of the clinical and pathologic material was possible in 9 and significant urologic abnormalities were found in 7. Among patients with bladder cancer there were no falsely negative reports. Urinary cytology is a reliable procedure in the diagnosis of urologic malignancies. Unconfirmed positive results require careful examination and followup.

Adult↗

PubMed1977

Malignant penile horn.

The fifth case of carcinoma within a penile horn is reported in a patient who also had erythroplasia of Queyrat of the glans penis. Penile horns should be considered as pre-malignant lesions, since a third of them undergo malignant change and they may be associated with a pre-malignant condition of the glans penis.

Carcinoma in Situ↗

PubMed1977

Determination of baseline values for urinary carcinoembryonic antigen-like substances.

Carcinoembryonic antigen-like substances were measured in urine samples from 236 apparently healthy, asymptomatic individuals. Twenty-four-hour collections were submitted by 177 subjects, and random specimens were collected from 59 others. In addition to CEA measurements, bacterial colony counts and cytologic examinations were performed on the latter. Baseline values were established for males and females and data were analyzed for the effects of age, smoking, time of collection, and bacterial colonization. Results indicated that levels of CEA-like substances in the urine could be greatly altered by bacterial conlonization. Lesser effects were noted with age and time of collection. Smoking had no demonstrable effect. These variables should be considered for meaningful interpretation of urinary CEA values of patients suspected of urothelial malignancy.

Adult↗

PubMed1976

The long-term course of carcinoma in situ of the uterine cervix.

The malignant potential of carcinoma in situ (CIS) of the uterine cervix has been the subject of great controversy. Despite refinements and additions to knowledge in this area, few reports on the long-term course of the disease have appeared in the past decade. Recent developments in diagnostic and therapeutic techniques coupled with changes in the patient population with this disease have prompted renewed interest in conservative management. Results of long-term observation of a group of patients followed initially without ablative therapy are reported. The data indicate that CIS of the uterine cervix is not the inevitably progressive disease that it has been considered to be. Unequivocal invasive cancer develops in only a small percentage of cases and can be controlled, if not cured, by current therapeutic modalities. The intraepithelial lesion, however, tends to persist despite conization, and eventually requires ablative therapy in most cases. Conservative procedures should be regarded as temporizing, at least until their long-term benefits can be recorded.

Adult↗

PubMed1976

Cytology in the diagnosis and followup of transitional cell carcinoma of the urothelium: a review with a case series.

Acceptance of the value of urinary cytology in transitional cell carcinoma has been mixed. Over-all accuracy is only fair to good and the results in mass screening are poor. However, cytology can be valuable in the serial evaluation of selected patients by the collection of multiple specimens. It is an important adjunct in upper tract lesions, in carcinoma in situ and in the evaluation of the patient with unexplained hematuria. Herein we analyze patients with transitional cell carcinoma of the urothelium with special reference to the use of cytology irrigation specimens from the bladder and the renal pelvis as an initial diagnostic tool and as an adjunctive technique for the evaluation of recurrence.

Adult↗

PubMed1976

Sickle-cell disease and poststreptococcal acute glomerulonephritis.

The cases of three children with sickle-cell hemoglobinopathy and acute poststreptococcal glomerulonephritis are described and discussed. Light and electron microscopic findings in three cases, and immunofluorescence microscopic findings in two are described. Since proliferative glomerulonephritis of either poststreptococcal or non-poststreptococcal etiology may be seen in patients who have sickle-cell disease, immunofluorescence and/or electron microscopic examination is essential for accurate diagnosis.

Acute Disease↗

PubMed1974