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Biomedical subjects

W L Qiu

Publications and source records attributed to W L Qiu.

At least 91 records · Page 5Linked to original sources
PubMed1994

[Orthognathic surgery of dentofacial deformities post surgerical repairing of cleft palate and lip.].

10 cases with maxillary development limited post surgical repairing of cleft palate and lip were undergone modified Le Fort I segmental osteotomy,that is,put the maxilla forward without velopharyngeal function change and oro-nasal fistula.By Computer Aided Simulation System for orthognathic surgery(CASSOS),analysis of dental pulp,evaluation of velopharyngeal function,compacting profile pre-to-post operation, authors described that surgical procedure has the satisfactory effectiveness.

English Abstract↗
PubMed1994

[Radioimmunological localization study using 131-iodine radioalbelled monoclone antibody ASC5 against human tongue squamous-cell carcinoma.].

Nude mice carrying human tongue squamous-cell carcinoma xenografts were studied in vivo.McAb ASC5 were purified from ascitic fluid obtained from BALB/c mice pristane-primed prior to being inocualted intraperitoneally with hybridoma cell,using with protein A sepharose CL-4B.Nude mice bearing xenografts were given i.v,injection of McAb labelled with 1311 and 1251.Mice were imaged daily with PHO gamma camera and sacrificed at interval after i.v.injection,weighted and counted.Gamma scanning indicated that there were a larger amount of activity detectable in tumor at 72h after i.v.injection 1311ASC5,then the tumor could be more clearly visualized at 96h and remained strongly position over the 7-day period,with the background activity decreasing.Tumor to non-tumor ratio was more than 2.9.It was secondary best of the antibody uptake at 72h,approximately 9.20+/-1.96%ID/g(mean+/-SD),which compared with isotypical antibody-paired normal mouse IgG,the difference was significant at P<0.05.Results demonstrated that ASC5 is useful in localization diagnosis and management of cancer.

English Abstract↗
PubMed1994

[Differential diagnosis between infection and neoplasm of the infratemporal fossa].

Because there are many similarities in infection and neoplasm of the infratemporal fossa (ITF), it is difficult to differentiate between these two diseases. By analysing 28 cases of the ITF lesions (8 cases of infection, 20 cases of neoplasm) the authors find the following points are important to differentiate between infection and neoplasm of the ITF. 1. The patients suffering from ITF infection almost all have odynophagia, while the patients suffering from the ITF neoplasm have no such symptom. The latter presents numbness in branches of the fifth nerve, while the former scarcely exhibits this symptom. 2. In the ITF neoplasm the mass could be found by CT or MRI, while in the ITF cellulitis no mass could be found. Although CT or MRI could find the mass in the ITF abscess, at the same time CT definitely could find some imaging signs which signify infection such as abscess formation (lucency) and gas bubbles. CT could find adjacent bone destruction in most ITF neoplasms, while this is rare in (ITF) infection. MRI is very helpful in differentiating between these two.

Carcinoma, Squamous Cell↗
PubMed1994

[Verapamil enhancement of antitumor effect of mitoxantrone on ACC-2 cell line in vitro and in vivo].

In this study, we investigated the effects of combination of Ca++ antagonist verapamil (VP) with a new anticancer agent, mitoxantrone (DHAD) on the growth of human adenoid cystic carcinoma cell (ACC-2) in vitro and in vivo. Non-toxic VP enhanced the cytotoxicity of DHAD in ACC-2 cells and significantly inhibited the cell proliferation. VP potentiated DHAD's inhibitory effect on incorporation of 3H-TdR into ACC-2 cells. When combined use of VP with DHAD, IC50 of DHAD on DNA synthesis decreased by 3.32 fold. FCM analysis showed that VP enhanced the block effect of DHAD on ACC-2 cell cycle traverse, causing cell accumulation in the G2M phase. In vivo study also proved that VP enhanced the tumoricidal effect of DHAD on ACC-2 implanted to nude mice. The inhibitory rate of tumor growth was increased from 57.9% to 88.4% when DHAD was administered with VP.

Animals↗
PubMed1994

[Comparison of antitumor activity of tumor draining lymph node lymphocytes and peripheral blood lymphocytes in human oral cancer].

The in vitro and in vivo antitumor activity between DNL and autologous LAK cells was compared. The results showed that DNL cells activated in vitro by rIL-2 exhibited higher cytotoxicity to Tca 8113 cells than the same patient's LAK cells (75% and 36%, respectively). According to Winn's method, the inhibition rates of subcutaneously transplanted Tca cells in mice were 74% and 42% respectively. There was significantly difference in the antitumor activity in vitro and in vivo between two groups (P < 0.05), indicating that DNL cells which are more available are more practicable for adoptive immunotherapy.

Adult↗
PubMed1993

[Lingualoplasty with modified forearm flap: A preliminary report with 6 cases]

A modified technic with forearm flap for lingualoplasty after ablative surgery for tongue cancer is reported.The tongure flap is pedicaled with the root of tongue by the residual excixion margin,and an oblique incision is made on the side of the placed forearm flap.Finally,the tongue flap is inlaid into the forearm flap in order to increasing the moving activity and function of the flap.This method has been applied to treat 6 patients of the tongue cancer.For them,the objective comments for function of the tongue after operation was given.

Journal Article↗
PubMed1993

[Reconstruction of large performated maxillofacial defect with immediated revascularized flap]

Patients with large perforated maxillofacial defects resulting from combined craniomaxillofacial resection or extended extra cranio-maxillofacial resection due to malignances in this region had been reconstructed with large revascularized myocutaneous flap or combined pedicled myocutaneous flap with revascularized flap.Since January,1981,a total of 29 flaps was used,of which 28 flaps survived successfuly,whereas one free forearm flap being failed to survive due to venous embolization was replaced with pedicled forehead flap.The results in postoperative appearance and rehabilitation of physiological function were relatively satisfactory.Finally,selection of flap and method of reconstruction were introduced and experiences on immediate reconstruction after malignance resection reported.

Journal Article↗
PubMed1993

[Quantitatively study of voice onset time-Glottal stop]

To quantitatively evaluate the acoustic characteristics of glottal stop, pronunciation of/ka/in 10 normal subjects and 14 patients with cleft palates were analyzed by sound spectrography and 20 msec in all normal articulation of /ka/ with an average time of 44.6 msec.In the test group of /ka/ demonstrated an average time of 20.8 msec.The inverse correlation ship between VOT and the psyco-acoustical judgment for the degree of distortion was demonstrated to be significant.

Journal Article↗
PubMed1993

[Verapamil enhancement of antitumor activity of mitoxantrone on ACC-22 cells in citro]

The combined effect of verapamil and DHAD on the growth of human adenoid cystic carcinoma cell line(ACC-2) in vitro was investigated.In combination, VP and DHAD had synergistic inhibitory effect.VP enhanced the cytotoxicity of DHAD in ACC-2 cells and significantly inhibited the cell proliferation.VP also potentiated the inhibitory effect of DHAD on colongenic ability of ACC-2 cell,suggesting it enhance the cytocidal effect of DHAD on human adenoid cystic carcinoma.

Journal Article↗
PubMed1992

Cephalometric analysis of maxillofacial morphology in unoperated cleft palate patients.

This study was designed to investigate maxillofacial morphology in adolescents and adults with unrepaired cleft palate, with or without cleft lip. Twenty-two Chinese patients with unilateral cleft lip and palate (the UCLP group), and 21 Chinese with cleft palate (the CP group) were cephalometrically evaluated and classified into the five ranges established from the means and standard deviations for matched normal Chinese populations. Many subjects in both UCLP and CP groups showed an intrinsic maxillary retrusion and a steeper mandible. The others had nearly normal maxillofacial morphology. The tendency for maxillary retrusion and a steeper mandible became increasingly remarkable with age. In the long axis of upper incisors in subjects with permanent dentition, there were no UCLP subjects with labial inclination, whereas three CP subjects exhibited labial inclination.

Adolescent↗