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Biomedical subjects

W L Qiu

Publications and source records attributed to W L Qiu.

At least 55 records · Page 3Linked to original sources
PubMed1997

Selection of adenoid cystic carcinoma cell clone highly metastatic to the lung: an experimental study.

Lung metastasis is very common in patients with adenoid cystic carcinoma (ACC). The purpose of the present study is to establish a model for an experimental study of ACC metastatic mechanisms and antimetastatic procedures. After five repeated selection in vivo, combined with an in vitro cloning technique and analysis of platelet aggregation activity, a clone (Acc-M) highly metastatic to the lung was selected from an ACC cell line (Acc-2). The metastatic rate was 96% vs 18% for Acc-M and the Acc-2 cell line. The metastatic rate and the weight of the lung with metastases correlated positively with platelet aggregation activity. The present study might be important for research into mechanisms of ACC metastases.

Animals↗
PubMed1997

[Cephalometric analysis in the patients of TMJ ankylosis with OSAS: Skeletal morphology]

By cephalometric analysis of 18 normal men and 12 men who got TMJ ankylosis with obstructive sleep apnea syndrome(OSAS),the authors reported that there were cephalometric characteristics in the patients:the craniomaxillofacial bones displacement posteriorly and superiorly,and demonstrated that it is key to advance the patients' jaws and enlarge the upper airway space.

Journal Article↗
PubMed1997

[Cephalometric analysis in the patients of TMJ ankylosis with OSAS: Soft tissue morphology]

By cephalometric analysis of 18 normal men and 12 men who got TMJ ankylosis with obstructive sleep apnea syndrome(OSAS),the authors reported that there were cephalometric characteristics in the patients:the posterior airway space(PAS) decreased(P<0.001),and the rate of (TA+SPA)/OPA remarkably increased(P<0.001),so the two parameters are significant for the diagnosis and treatment of the patients.

Journal Article↗
PubMed1997

[Observation of clinical and pathological responses in short-term following immunochemotherapy for oral squamous cell carcinoma]

24 patients with oral SCC in Stage T3 or T4 were randomly divided into two groups,and treated with two inductive therapies,13 cases of whom received an immumochemotherapy regimen(Sapylin 15 KE+CDDP 70mg/m(2)+VCR 1.4mg/m(2)+PYM 80mg,S-PVP) and 11 cases,a chemotherapy regimen(CDDP 90mg/m(2)+VCR 1.4mg/m(2)+PYM 80mg,PVP) as control.The clinical response and pathological effect after immunochemotherapy or chemotherapy were evaluated through the clinical measurement of tumor size and pathological examination of the specimen.The results showed that the rate of clinical and pathological responses in S-PVP group were 92.3% and 84.6%,respectively;and in PVP group,72.7% and 45.5%.There was a significant difference between two groups in pathological effect(P<0.05),which indicated that the S-PVP regimen in short-term was better than of inductive chemotherapy.It may be relatively objective and accurate in comparison with clinical investigation which could act as an important supplement to the evaluation of clinical response.

Journal Article↗
PubMed1997

[Effect on intratumoral T lymphocyte and its subset in oral squamous cell carcinoma following immumnochemotherapy]

The relative numbers of CD(3)(+),CD(3)(+),CD(8)(+) and HLA-RD(+) cells in the tumor tissue before and after inductive therapy was counted using immunohistochemical technique of Avidin Biotin-Peroxidase Complex(ABC),and then the effect on local immune cell following two different inductive therapies was comparatively analysed.The results showed that S-PVP therapy could result in significant increasing in numbers of CD(3)(+)and CD(4)(+) cells intratumorally as compared with pre-therapy(P<0.05),and in slignt increasing in numbers of CD(8)(+) and HLA-DR(+) cell,which is no significant difference between pre-and post-therapy.In the PVP group,there was no significant difference in numbers of CD(3)(+),CD(4)(+),CD(8)(+) and HLA-DR(+) cells between pre-and post-treatment.The results suggested that T lymphocyte in the tumor site could significantly increase in numbers following the S-PVP therapy,and PVP chemotherapy did not obviously affect the local cellular immunity.

Journal Article↗
PubMed1997

[Yield and cytotoxicity of tumor-infiltrating lymphocyte(TIL) following immunochemotherapy]

Tumor-infiltrating lymphocyte (TIL) in the primary site of oral SCC treated with S-PVP of PVP therapy was collected respectively and its yield,that is calculating the amount of TIL per tumor tissue.The cytotoxicity of TIL against the target,Tca8113 was detected.The results showed that the yield of TIL in S-PVP group was three times over that in PVP group.At the ratio of 5 to 1 (effector to target) the cytotoxicity was 38% in S-PVP group and 32% in PVP group.There was no significant difference in its cytotoxicity between two groups.The results revealed that immunochemotherapy of S-PVP regimen for treating oral SCC had neither direct damage to tumor cell from the agents nor antitumor immune reactivity with BRM stimulating an increasing in numbers of TIL.

Journal Article↗
PubMed1996

[The management of the treatment and diagnosis for the calcifying odontogenic cyst]

18 Patients with calcifying odontogenic cyst underwent surgery in our Department from 1977 to 1993 were reported.8 male and 10 female aged from 11 to 52 with medium or 33 years were included.16 cases were pathologically confirmed as primary intraosseous cyst(central),and 2 as extraosseous cyst(peripheral).There was no recurrence after the local excision for preripheral calcifying odontogenic cyst and local curettage for central one.There were 3 in 6 cases of tumor typed cyst who had recurred postoperatively,two of them had recurred repeatedly and cured by means of local radiotherapy.The authors recommend that the tumor type of intraosseous calcifying odontogenic cyst be classified as a border-line tumor and treated as well as the principles of low malignant tumor.Post-operative radiotherapy could be used for recurrent cases.

Journal Article↗
PubMed1996

[Diagnostic arthroscopy of the Maraca mulatto's TMJ]

To gain further knowledge about features of Maraca mulatto's TMJ,occlusion,and teeth,we underwent examining 4 rhesus monkeys with 8 joints.The same and different features were concluded between Maraca mulatto's anatomical structures and human begins.Afterwards,10 aged rhesus monkeys with 20 joints were examined by TMJ arthroscopy.The results showed that the appearances in 70%(14/20) of the aged were the same as those in human pathologic TMJs. In conclusion,the Maraca mulatto can suffer from the same arthropathy as human being,and it is possible to choose the aged as a natural pathologic model.

Journal Article↗
PubMed1996

[A prospective study evaluating effectiveness of TMJ arthroscopy for particular stages of internal derangement]

The purpose of this prospective study is to evaluate effect on particular stages of internal derangement by TMJ arthroscopy.According to Wilkes-Bronstein classification,the distributions between 81 joints and particular stages of ID were:25 joints in II stage,18 in III,24 in IV,and 14 in V.The total 81 joints were undergone by arthroscopic surgery,the total success rates of different stages of ID were:24/25 joints in II stage,16/18 in III,13/24 in IV,and 7/14 in V particularly.The success rates were no statically significance (P>0.05) between II stage and III stage or between IV and V or V stages.The conclusion is that these cases in II or III stages of ID choose arthroscopic surgery than those cases in IV or V stages.

Journal Article↗
PubMed1996

[A retrospective study evaluating effectiveness of different TMJ arthroscopic techniques for discal displacement with or without reducing]

The three arthroscopic techniques were particularly method I(lysis and lavage),method II(disc repositioning and sclerotherapy plus method I),method III(traction,fixation plus method II) in order to make comparative study.The distributions between the 76 joints and three techniques were:14 joints in method I,31 in II,and,31 in III.The total follow-up was 30m(6-84m),and the total success rate was 73.7%(53/76).The mean follow-ups were particularly:28.6m in method I,38.4m in II.and,74.2%(23/31) in III,particularly.There were no statically significance between I and II.In disc displacement with reducing,there were no statically significance between method II(18/20) or III(14/15) and I(1/40),and no statically significance between II and III.In disc displacement without reducing,there were no statically significance between method I(6/10)and II(8/11) or III(9/16),or between II and III.Conclusions were that II or method III was effective on disc displacement with reducing,and that it don't make clear for any one of three methods to be more effective on disc displacement without reducing.

Journal Article↗
PubMed1996

[Clinical management of tumours in the infratemporal fossa and parapharyngeal space:A report of 44 cases]

From June 1971 to June 1993,44 cases suffered from tumors of the infratemporal fossa and parapharyngeal space were summarized on their materials showing thirty-one of them were benign tumors which first arised in the true deep lobe of the parotid gland and next in the neruolemma.Thirteen cases were malignant tumors arising in several tissues.The chief clinical sign in these patients was a lateral pharyngeal wall bulge and deformity without pain.A few patients occured change in voice characteristics or diffculty in swallowing.All these patients were performed surgery.93%(41/44)of patients were followed up.The longest follow-up has lasted 20 years.In this paper,the specific clinical appearance,diagnosis and surgical technique for tumors of the infratemporal fossa and parapharyngeal space are further discussed by us.

Journal Article↗
PubMed1996

[A randomized clinical trial for the evaluation of head and neck squamous cell carcinoma treating with traditional Chinese medicine]

This paper described the research design,research process and statistical analysis of randomized clinical trial by treatment with traditional Chinese medicine in patients with squamous cell carcinoma of the head and neck.At first we found there was no significant difference between treating group and contral group(P>0.05) using log-rank test on Kaplan-Meier survival curves. With further multivariate analysis Cox model and after adjusting for sex,age,legth of taking the assigned medication,grade of tumor differentiation and using of chemotherapy,the rate of tumor-related death for control group was significantly higher than that for treating group :hazards ratio estimate was 1.939(95% confidence interval 1.008-3.729,(P<0.05).The length of taking Chinese medicine was one of the most important prognostic factors(P<0.001).The results suggest that the prescribed medication contributed to the improved survival,and it was an independent prognostic factor.

Journal Article↗