Biomedical subjects
Publications and source records attributed to W Krause.
Testosterone, FSH and LH were measured in serum of patients suffering from prostatic carcinoma. The efficacy of treatment with 1 mg diethylstilbestrol/d (Cyren A) was shown by suppressed serum levels of testosterone, FSH and LH comparable to castration in a follow-up until 560 weeks after beginning of therapy. Prolactin was raised in all patients under treatment.
Explore the source record for details and available documents.
We explored 183 deliveries in breech presentation. The birthweights from this offsprings were 1941 +/- 418,1 g. 101 were primiparae. The perinatal mortality of the underweigth fetuses was 5 more higher when delivered vaginally in relation to delivery by caesarean section. These differences were statistically significant (p less than 0,05). In relation to multiparae 71,8% of the offsprings survived when delivered vaginally, in comparison to 79,2% offsprings from primiparae. The APGAR-scores (1 and 5 min. p. p.) less than or equal to 7 or greater than or equal to 8 showed no significant differences by the offsprings delivered vaginally or by caesarean section. The pHNA was higher in the group of children, delivered by means of caesarean section. The conclusions are discussed.
The FSH release from the hypophysis is suggested to be particularly regulated by a testicular hormone called inhibin. Origin, structure and target organs of inhibin are unknown. Experiments to test some hypotheses in this field are described. Adult male rats, prenatally treated with busulfan, show only Sertoli cells in the semiferous tubules. Experimental cryptorchidism and orchidectomy, however, leads to an increase in FSH levels as observed in normal animals. This indicates the role of Sertoli cells in FSH regulation. Ligation of efferent ducts of testes leads to an increase of FSH levels, too, indicating that an FSH-inhibiting principle cannot be absorbed. Interstitial testis fluid (ITF) of normal rats was applicated to immature female rats. Their FSH release is inhibited, visible in the lower ovarian weight gain following additional hCG-administration. Orchidectomized animals react with a decrease of FSH levels to the application of ITF. Therefore ITF seems to contain a FSH-inhibiting factor. Androgen binding protein-content of epididymes, however, is increased after repeated injections of ITF. It is concluded that testis (probably the Sertoli cells) produces a FSH-inhibiting factor, but ITF contains only small amounts of inhibin.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Groups of adult male rats were treated with DDT, DDVP or malathion orally for two or three weeks. Body weight and testis weight did not change. FSH and LH levels in serum also remained unchanged, whereas that of testosterone was decreased by DDT. This substance also diminished the concentration of testosterone in the testis. Therefore, the previously observed damage to spermatogenesis by DDT are assumed to be caused by a lack of androgens. Those following treatment with DDVP or malathion seem to be due to a direct cytotoxic effect.
In 69 male acne patients, 15--24 years old and 17 young men of the same age plasma FSH, prolactin, testosterone and estradiol are determined. Only the mean testosterone levels are significantly elevated in acne patients against the controls.
Adult male rats prenatally treated with 1,4-bis-(methanesulfonyloxy)-butane (busulfan), which damages the gonocytes, undergo cryptorchidization, castration or testosterone treatment and the FSH, LH and testosterone levels in serum are measured. Basal values of these hormones do not differ from those of controls. After cryptorchidization FSH levels rise but the LH levels do not. Following orchidectomy both hormone levels increase significantly. Application of testosterone in various doses increases FSH in normal animals but not in busulfan treated rats 24 h post infectionem. FSH and LH levels 7 days after administration do not differ from controls. According to the hypothesis that the FSH release depends on an inhibin from the testes, these experiments show evidence for inhibin being produced only in the Sertoli cells.
Lipoxygenase from rabbit reticulocytes cause disruption of mitochondrial membranes and peroxidation of their lipids as judged by electronmicroscopy, release of matrix enzymes and formation of malonyldialdehyde. Without substrate mitochondria become orthodox and strong lysis by lipoxygenase appears. The lysis is prevented by ATP or ADP plus succinate; in this case mitochondria remain condensed or partly condensed. The protection by substrate was even observed in the presence of 2,4-DNP, although the mitochondria were transformed to the condensed state. Lysis was more pronounced in hypotonic than in hypertonic sucrose, condensed mitochondria are also attacked. No relation seems to exist between lipoxygenase attack and the conformational state of mitochondria. Lysis of mitochondria is dependent on the susceptibility of the fatty acid moiety of phospholipids, which may be influenced by both metabolic and structural events via alteration of protein-lipid interactions.
The digital estimation of utero-placental circulation by means of nuclear-medical examinations with help of 113 m In-Cl and regarding to the "region of interest" gives no depositions in cases with an intrauterine retardation. This concerns the activity as well in the placenta as in the uterus too. Exceptions represents intrauterine retardations on the base of heaviness EPH-gestosis and placenta previa. Herewith the rise of activity corresponds with the thickness in the III. trimester of pregnancy. A treatment about several weeks with Hepain under bed conditions leads to no proofed influence of the uteroplacental circulation, on the contrary to a rise of estriol and HPL-values, meaning a improvement of placental performance. The estimation of the utero-placental circulation by means of nuclear-medical examinations is situated to the problem of fetal condition by EPH-gestosis, placenta previa and other.
The treatment of subfertile men with HCG and HMG over 20 days does not produce statistically significant increase of sperm count, their motility and their mophology.
Explore the source record for details and available documents.
89 mal patients with fertility disorders underwent a test with 50 mug synthetic LH-RH. The basal levels of FSH and LH are elevated in patients with azoospermia, with testicular atrophy, varicocele and Klinefelters syndrome. They increase with age. After stimulation with LH-RH the highest relative peaks (maximal value divided by control value) of LH are seen younger patients, in those with varicocele, and oligozoospermia. The FSH-values do not differ significantly between these groups. Low relative peaks of LH are seen in older patients. In Klinefelter's syndrome the relative peaks of FSH and LH are significantly lowered.
1. Malformations and functional disturbances of the male genitalia may be caused by teratogens. 2. A short review of the prenatal development points out the possible sites of action. 3. In animals some distinct teratogens produce typical malformation syndromo spermatogenetic cells. Cyproteronacetat, an antiandrogen, suppresses the development of the accessoric genital organs and produces an external feminisation. 4. In man, cryptorchidism, agenesis of the spermatic tracts, anorchia and hypospady are known as non-hereditary malformations. 5. The teratogenic etiology of some disturbances of the spermatogenesis is discussed.
Explore the source record for details and available documents.
Juvenile male rats received either 20 mg DDVP or 40 mg malathion/kg on the 4th and 5th day of life, and either 10 mg DDVP or 20 mg/kg malathion daily from the 4th to the 23rd day of life. The histological examination of the testes showed slight reductions of the spermatogentic cells and Leydig cells. Therefore, it is assumed that testosterone synthesis is reduced, followed by damage to spermatogentic cells. All disturbances return by normal by the 50th day of life.
Male rats of the Wistar/Han strain are treated with ovine FSH, hCG or PMS in various doses for twelve days, beginning on the 1st, 12th, 24th or 36th day of life each. The determination of FSH in plasma by radioimmunoassay at the end of the treatment shows that all exogenous gonadotropins depress the FSH levels to immeasurable values. Plasma testosterone increases after application of hCG and PMS, not ovine FSH. To explain these findings a hypothalamic inhibition of the FSH release by a "short feedback" mechanism is discussed.