[Hemochromatosis and fertility disorders].
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Biomedical subjects
Publications and source records attributed to W Krause.
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Ascertainments on notifications of cases of taeniarhynchosis and of the consumption of taenial therapeutics in the regions of the district of Leipzig during the period 1967-1970. The factors are discussed which have influence on notifications or on the consumption of taenial therapeutics. From these examinations resulted, that consumption of taenial therapeutics come near to genuine extensity of the population, but it is not equal to this. The causes, at present, for bad notifications must be found and changes must be introduced. The statistics of numbers on consumption of taenial therapeutics must be improved and the sector of veterinarian science must be excluded.
We demonstrate an enlarged and modernized equipment for the on-line-fetal monitoring. With the aid of illustrations the received informations by help of continuous on-line-fetal monitoring are demonstrated too. They concerned the deposition of electronical and corresponding gasanalytical dates. The importance of registration from all obstetrical parameters and given up drugs by a code-system is put out. Furthermore preferences of the computations are discussed.
100 women were examined in labor upon the so-called intensive birth room. In this connection we discovered, that the prevailing number of women to be in labor had a positive position to the surrounding modern implements for the continuous fetal monitoring. Explanation and a corresponding preparation to birth by means of consultations and psychopropylactic methods cut a great figure. Education, profession and social position were factors, influencing the answers in the same form how the position from the mother to the present pregnancy.
Prolactin (PRL), a peptide hormon from the hypophysis, becomes more interesting, since it can be determined by radioimmunassays. The release of prolactin is controlled by two not yet identified factors, the prolactin-releasing-factor and the prolactin-inhibiting-factor. The latter predominantes. Many pharmacological substances can alter the release. The normal serum levels in the man are 6-13 ng/ml. Prolactin affects many organs, f.e. kidney, mamma, ovary, testis, hepar and skin. For clinical tests the raise in the serum levels after TSH or chlorpromacin and the drop after application of 2-brom-alpha-ergocryptin is used. Increased serum levels are found in patients with prolactin-producing tumors. In the male this is followed by disturbances of the sexual potency. Relations between prolactin and male infertility of gynecomastia are not yet known.
In the period from 1.1. 1970 to 31.3 1975 we found under 11876 deliveries in 56 cases polyhydramnios (= 0,47%). Deformities by the newborns we have had in 8,9%! A timely observation and therapy of the polyhydramnios are able to diminish the risk for mother and child. The therapy of choise is a frequently transbdominal amniocentesis after localization of the placenta. A partus praematurus we could'nt avoid generally. An compulsory fetal monitoring of this patients is necessary, because many of this deliveries are high-risk deliveries.
Male adult, intact rats were treated with 1000 or 2000 mug/kg testosterone propionate (TP), 500 or 1000 mug/kg estradiol benzoate (EB) or ol. arachidis only. 30 min, 24h, 48h and 7 days later they were injected with 5 mug/kg LH-RH or saline solution. 30 min after this FSH, LH and testosterone were determined in plasma by radioimmunoassay. It is shown that pretreatment with 500 mug/kg TP enhances significantly the FSH release after LH-RH even on day 7, while the greater dose of TP does not significantly affect the release of FSH. The LH-RH induced release of LH is also increased by the pretreatment with 500 mug/kg TP, while 2000 mug/kg TP do not alter the reaction to LH-RH. EB in both doses does not influence the LH-RH induced release of FSH and LH.
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The values of the transaminases (GOT, GPT) and the acid phosphatase in the ejaculate do not differ between men of known fertility and infertile men.
In connection with the observation of new quantitative electronic dates we undertook bradycardia résiduelle from Sureau a critical value in account. The investigations result from non-digital method. We didn't find statistical significant coherence between bradycardie résiduelle and Apgar-score past 1, 5, 10 and 60 minuts p.p., the pHf and the delta pHf. Also in relation to the neurological investigations of the corresponding children we hadn't statistical significant correlations. The causes for this perception are discussed.
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Juvenile male rats of Wistar/Han strain were fed DDT suspended in olive oil. They received either 500 mg/kg at the 4th and 5th or 300 mg/kg daily at the 4th till 23rd day of life. After certain interval the testes were examined histologically, and at the 60th and 90th day of life fertility was proved. The spermatogenetic cells showed an increase of the physiological degeneration in the course of spermatogenesis and a decrease of their total number. The number of Leydig cells was diminished. In parallel, the litters of normal female rats mated to treated males were smaller than those of controls. The hypothesis is suggested that the damage of the seminiferous epithelium can be explained by a lack of local testosterone.
Immature male rats receive orally DDVP 20 mg/kg on the 4th and 5th resp. 10 mg/kg on the 4th to the 24th day of life or malathione 40 resp. 20 mg/kg. At defined days the testes are examined histologically. The body weight does not change. The testis weight, tubular diameter, number of Sertoli cells, and of A-spermatogonia per tubular cross section as well as the number of Leydig cells is diminished. Malathione produced more severe alterations, they disappear, however, until the 50th day of life. Refering to the metabolic mechanisms of both the phosphatic esters a local lack of testosterone causing the disturbances is discussed.
Electroencephalograms showed - in accordance with many authors - important statements of perinatal damage and of her prognosis. The fetal monitoring (electronical and gasanalytical) is able to acknowledge in due time a hypoxic situation and procures favourable to the perinatal morbidity. Gross-pathological electroencephalograms we found in 5% of monitored high-risk babies in contrast to 17% of no monitored intrauterine patients.
From 19 with Heparin treated patients by suspicion of intrauterine retardation 12 patients were investigated relative to the physiology of coagulation. The placentae were investigated morphologically. The treatment with Heparin was without danger. A certain effect of the efficiency by the treatment with Heparin we couldnt establish. The theoretical introductions relative to the efficacy of Heparin entitled the further application of this drug. We can hope, that a better selection of patients with intrauterine retardation by help of ultrasound and other methods (sequenzszintigraphy with In113m and electronmicroscopical procedures) are able to establish the favourable impression by the clinical use of Heparin.
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The fate from children with a brithweight less than or equal to 2000 g in attendence of caesarean section is doubtful. From 35 children, born by caesarean section because of maternal and/or fetal indications died 17 (approximately 50 per cent). Maternal indication entitled always to perform sectio parva during the III. trimester of pregnancy--or to a earlier period. Clear fetal indication for caesarean section from the 34. week of gestation justified one-self. This is relative seldom. Caesarean section--performed before the 34. week of gestation--is changed with a high perinatal mortality and morbidity.