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Biomedical subjects

W Hofmann

Publications and source records attributed to W Hofmann.

At least 325 records · Page 18Linked to original sources
PubMed1978

[Therapeutic possibilities in ulcus simplex vesicae].

On the basis of own clinical experiences in the treatment of the ulcus simplex vesicae in connection with the special literature is described that frequent failures in therapy may be traced back to the up to now still uncleared genesis of the disease. According to the modern stage of knowledge the disease in question seems to be determined by trophoneurotic disturbances. Success in therapy may be achieved by interruption of pathological reflexes of the autonomous nervous system by means of infiltration of procoffin.

Adult↗
PubMed1978

[Secondary vesico-ureteral reflux in the adult age].

The transurethral dehiscence of the ostium is a therapeutic method which causes the spontaneous passage of incarcerated intramural ureteroliths. However, it may be performed only in the centre of the roof of the ureter to a maximum length of 0.5 cm. With lateral indentation the antireflux principle of the ostia of the ureters is abolished by damaging the reins of the intravesical musculature of the ureters. An asymptomatic reflux necessarily becomes a reflex disease, when it is complicated by an infection of the urinary tract. In secondary vesico-ureteral reflux by dehiscence of the ostium at adult age the indication to the operative treatment shall be made narrowly, since with the sanation of the infection of the urinary tract the reflux often disappears.

Humans↗
PubMed1977

[Coronary arteriosclerosis and risk factors in coronary heart disease (author's transl)].

A large number of cases were tested for the relevance of clinical risk factors in coronary heart disease with regard to coronary arteriosclerosis (atheroma, fibrosis; five different locations). The method applied was VARIMAX-rotated factor analysis. The resulting factors were interpreted as the multiple variables structures which are in different relationships to the risk criterion, coronary heart disease, and morphological vascular diagnosis of the coronary arteries. The importance of the known risk of the vascular diagnosis was estimated and the reterance of the clinically influencing criterion was discussed. It appears that in spite of limited methodology additional morphological criteria are required in order to be able to explain heart infarction which does not involve the epicardial branches of the coronary vascular system.

Adult↗
PubMed1977

[The influence of beta-sympathomimetics and so-called Ca++-antagonistic inhibitors on human heart muscle in vitro (author's transl)].

In an in vitro assay on fetal human heart muscle it was demonstrated for the first time that overstimulation by beta-sympathomimetics could cause elective parenchymal necrosis. Fenoterolhydrobromide, which is used for tocolysis on a longterm scale, induces in vitro necroses of individual heart muscle fibers according to a pathogenetic principle postulated by Flekkenstein. The combination of Fenoterolhydrobromide with a Ca++-antagonist prevents elective parenchymal necroses by reducing the Ca++-influx into the heart muscle fibers. These results suggest that elective necroses of heart muscle fibers may be not only of coronarogenic but also of metabolic origin.

Calcium↗
PubMed1977

The binding constant of ATP to myosin S1 fragment.

The extent of ATP synthesis from ADP and Pi at the active centre of myosin subfragment 1 has been reinvestigated. The results have been interpreted using a treatment which is not dependent on the number or nature of the intermediates in the ATPase mechanism. An average value for the binding constant of ATP of (3.25 +/- 0.96) X 10(11) M-1 at pH 8.0 23 degrees C and ionic strength 0.12 M was obtained. Additional evidence is given to confirm that synthesis at the active site has been investigated.

Adenosine Diphosphate↗
PubMed1976

[The specific gravity of the excitation formation and conduction system of the heart compared to the working myocardium as an indication of differences in structure and composition (author's transl)].

Samples of heart conducting system tissue and samples of ordinary heart muscle (left heart, right heart, and septum interventriculare) were taken from the hearts of 50 prime-conditioned bulls. The specific gravity of the heart conducting system was significantly higher than that of ordinary heart muscle. This is surprising because it cannot be explained by a difference in water content. The question arises whether or not there are differences in the composition of protein and in the content of glycogen.

Animals↗
PubMed1976

Time function of corticosteroid levels in the blood plasma of rats under the influence of 222Rn inhalation.

The time function of cortocosteroid level in plasma of rats under two different 222Rn concentrations was investigated. Both curves show a maximum after 8h. Whereas the higher activity of 222Rn produces a second maximum after 5 days, the lower activity reaches its second maximum not before 9 days. From both time functions, a two-step mechanism in the intracellular control can be concluded.

Adrenal Cortex Hormones↗
PubMed1976

A simple method for differentiating vascular smooth muscle cells and fibroblasts in tissue culture.

The morphologic differentiation of vascular smooth muscle cells and fibroblasts in tissue culture is difficult if not impossible. By direct immunofluorescence, it is possible to distinguish between vascular smooth muscle cells and fibroblasts after 6 to 10 days in tissue culture. Microfilaments appear from the 6th to the 10th day. After an incubation period of 30 minutes with antibody against smooth muscle actomyosin at room temperature, microfilaments are demonstrable in smooth muscle cells. In contrast, fibroblasts, if incubated for the same period, show strong nuclear fluorescence and a primary fluorescence of the cytoplasm, but filaments are not visible. If fibroblasts are incubated with antiactomyosin for one hour at 37 degrees C, however microfilaments are easily detectable. With this method it is possible to differentiate in a simple manner vascular smooth muscle cells from fibroblasts in a heterologous tissue culture.

Actomyosin↗
PubMed1976

The effects of betamimetic drugs used for tocolysis on the fetal myocardium.

During the last five years tocolysis with betamimetic drugs, e.g. Fenoterol has become a standard method for the treatment of impending premature births. We studied the effect of Fenoterol in vitro on organ cultures of human fetal hearts. At a concentration in the nutrient medium corresponding to the dose used in clinical application, light and electron microscopy demonstrated myocardia damage. In contrast the combined use of Fenoterol and the calcium antagonist Verapamil in a ratio of 1:40 showed no pathological findings either clinically or in vitro. The results are documented with light and electron photomicrographs.

Ethanolamines↗