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Biomedical subjects

W Hofmann

Publications and source records attributed to W Hofmann.

At least 307 records · Page 17Linked to original sources
PubMed1980

[The clinical problem of living with one kidney].

The chance on a complete compensation of the residual kidney is the larger the earlier the nephrectomy as performed. Infections of the urinary tract, pyelonephritis, affection with calculi and functional disturbances are the most frequent diseases of the residual kidney particularly then, when the contralateral organ was also removed for these reasons. Specific tuberculous inflammations and tumorous affection of the residual kidney rarely appeared.

Humans↗
PubMed1980

Stereochemical aspects of the interaction of myosin and actomyosin with nucleotides.

The five possible analogues of ATP and the three possible analogues of ADP which contain single non-bridging sulphur atoms instead of oxygen in the polyphosphate structure have been used as probes of the interaction of nucleotides with myosin and actomyosin. Evidence is presented for the requirement of an alpha, beta, gamma-tridentate complex of magnesium and ATP as the substrate for myosin. Of the four possible tridentate MgATP diastereomers, the delta exo isomer (nomenclature of Cornelius & Cleland, 1978) appears to be the actual substrate.

Actomyosin↗
PubMed1980

Effects of cimetidine upon gastric secretion and mucosal blood flow in the rat stressed by restraint. A dose-response and prophylaxis trial.

The effect of the histamine-H2-receptor blocking agent cimetidine (CT) on gastric secretion, mucosal blood flow (MBF), and gastric mucosal stress ulcer index was studied in rats (n = 96) during control conditions (3.9, 15.6, 62.4 microMol/kg/h CT i.p. over 8 h) with calculation of kinetic constants (Vmax; Km) for gastric secretion, MBF and ulcer index, it is shown that CT actions become considerably modified by severe stress. Under mild stress the reduction of MBF and acid secretion by increasing CT doses is parallel. Severe stress alone reduces MBF more than gastric acid (65 vs. 30%). This phenomenon is partly reversed by a dose of 62.4 microMol/kg/h (= 16 mg/kg/h), which is associated with the lowest ulcer index observed. There is no significant correlation between the latter and either acid concentration, acid output, or MBF. The concentrations of pepsin in gastric juice or of serum gastrin neither change with severe stress alone or with additional CT. It is concluded that CT has anti-stress ulcer properties coinciding with reduced acidity in the gastric lumen, but that in addition this beneficial effect may be mediated by factors other than acid reduction.

Animals↗
PubMed1980

[Comparative investigations (computed tomography, X-ray diagnostics, scintigraphy) for the detection of radiation-induced alterations of the lung (author's transl)].

Radiation-induced alterations of the parenchyma of the lung were investigated in 24 rabbits before, during and after irradiation of the left lung. Of the experimental animals 12 received a surface dose of 50 Gy, the other half 40 Gy, equivalent to a focal dose of 47.5 resp. 38 Gy in the middle of the lung, with a fractionation of 10 Gy per week. By means of lung-scintigraphy (99mTc-MAA) radiation-induced obstructions to perfusion could be demonstrated in 93% of the experimental animals, only in 37% the detection of radiopneumonia was possible by computed tomography or by a roentgenogram of the thorax. In 70% of the experimental animals scintigraphic alterations could be detected already during radiotherapy, the alterations visible by computed tomography or roentgenology appeared much later. Here computed tomography allowed an earlier identification of differences in absorption than X-ray diagnostics.

Animals↗
PubMed1979

Leiomyosarcoma of the pulmonary artery. A light and electronmicroscopical study.

A 25-year-old man with chest pain and shortness of breath was found to have a primary sarcoma of the pumonary artery. On light- and electronmicroscopy and immunofluorescence microscopy the lesion was found to be composed of cells of smooth muscle origin. It was diagnosed as leiomyosarcoma. The cross and microscopic features of the tumor are described and the morphologic characteristics of previously reported vascular sarcomas are briefly reviewed.

Adult↗
PubMed1979

[Haemangioma capillare of the pleura with ipsilateral haemopneumothorax (author's transl)].

1. The article introduces a patient with left-side haemangioma capillare of the pleura parietalis with haemopneumothorax and ipsilateral cystic changes of the left upper lobe of the l,ng. 2. The aetiopathogenesis of the disease is discussed as an abortive type of Rendu-Osler-Weber disease (hereditary haemorrhagic telangiectasia), the diagnosis being based exclusively on histological findings as the only possibility of diagnosis. 3. The therapeutic approach is discussed.

Adult↗
PubMed1978

[The tensile strength of human zonule and its alteration with age (author's transl)].

A series of 91 cryoextractions was performed on autopsy material. The scleral section was placed near to the chamber angle and was nearly circumferential (about 330 degrees). Cornea and adjacent sclera could be flapped over this way, and did not interfere with a straightforward lens extraction. The pupil was medically dilated. A cryoprobe was fixed to a specially constructed scale, and frozen to the anterior pole of the lens. Its weight was counterbalanced by a plastic water container at the other end of the scale. The extraction was performed by filling additional water into the counterbalancing container. The statistical evaluation of the results showed a very significant dependence of the average tensile strength on age. However, a considerable standard deviation was found throughout all ages. The nutritional state of the autopsy bodies and the time interval between death and start of the measurement had no significant influence. The differences between right and left eyes were also not significant, as could be expected. The methodological error remained small. Age proved to be an unreliable indicator for the tensile strength of the zonule. All results apply to clear lenses. We known from clinical experience that the tenacity of the zonule may also be different in the various types of cataract.

Adult↗