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Biomedical subjects

W Grote

Publications and source records attributed to W Grote.

At least 91 records · Page 5Linked to original sources
PubMed1987

[General and special indications for extra-intracranial bypass operations in the light of an international cooperative study].

The results of the International Cooperative Study on Extracranial-Intracranial Anastomosis (EIAB) are discussed in the light of previous experiences and recently published criticisms of the Study. Modern diagnostic approaches are discussed to define patients who are at high risk of suffering further symptoms due to a haemodynamic compromise, who might still benefit from EIAB. Discussion about optimal therapy for patients with symptoms of cerebral ischaemia should be continued.

Adult↗
PubMed1986

[Embryonal malformation following etretinate therapy of Darier's disease in the mother].

A 22-year-old woman suffering from dyskeratosis follicularis Darier became pregnant 4 months after the last dose of etretinate (Tigason). The pregnancy was terminated in the 10th week because of teratogenic risk. The pathological examination of the fetus revealed severe malformation of the left leg with aplasia of tibia and fibula, as well as hypoplasia of the left femur. This observation emphasises the necessity of effective contraception even after discontinuation of etretinate therapy.

Abnormalities, Drug-Induced↗
PubMed1986

Diagnostic criteria in pituitary tumour recurrence--combined modality of surgery and radiotherapy.

The tumour recurrence rate of 210 patients with operated hypophysomas were investigated. Depending on the surgical approach, total or subtotal extirpation of the adenomas, the recurrence rates varied from 10,4 to 35%. 33 patients with pituitary tumour recurrences were followed up over a period of 20 years. Clinical symptoms CT-results at relapse are represented. Serum prolactin level (PRL) was determined before and after surgical and radiotherapy of PRL-producing adenomas. In these cases PRL can be accepted as a tumour marker. 13 patients with relapsed hypophysomas received local irradiation (5.7 MeV linear accelerator) after recurrence operation. An individual comparison in the same patient between surgical therapy alone and combined surgical and radiotherapy was possible. Based on the obtained experience with this combined treatment a therapy scheme using combined surgery and radiotherapy in pituitary tumours is suggested.

Adenoma↗
PubMed1986

Clinical application of event related potentials in patients with brain tumours and traumatic head injuries.

Event related potential recording and psychometric evaluation of cognitive impairment were carried out on 21 patients with brain tumours, 21 patients with severe head injuries and 24 controls. The tumour and trauma patients who met the psychometric inclusion criteria for dementia, but not the non-demented patients, had significantly longer N2 and P3 latencies than the controls. In assessing individual patients P3 latency correctly differentiated between demented and non-demented patients in 81% of cases (for N2 latency 77%). Particularly P3 latency may provide a practical and objective measure of mental impairment in neurosurgical disorders producing dementia. Marked asymmetry in N2 and P3 amplitudes between hemispheres was observed in a number of cases. No significant relationship was found between diminution of N2 and P3 components and side of lesion.

Adult↗
PubMed1986

Intralymphatic interleukin 2 treatment in patients with acquired immunodeficiency syndrome: preliminary experience in three cases.

Patients with opportunistic infections during the course of acquired immunodeficiency syndrome (AIDS) were analyzed for cellular immune functions and found to be severely immunocompromised. In particular, interleukin 2 (IL 2) production appeared to be defect not only qualitatively but also quantitatively. In some of these patients, exogenous IL 2 improved immune response in vitro. Intralymphatically administered highly purified natural IL 2 was given repeatedly (over a time period of ten days) to three of these patients. In two cases, such a treatment course was repeated later. Clinical response - at least in some patients - appeared to be of temporary benefit. Shortly after termination of IL 2 application in two patients an increase of lectin responsiveness as well as improved reactivity in skin testing was noted, encouraging further exploration of IL 2 as an immunostimulatory drug in AIDS patients.

Acquired Immunodeficiency Syndrome↗
PubMed1986

[Current status of the diagnosis and treatment of laterobasal skull fractures].

Latero-basal fractures of the skull base due to a blunt head injury may cause vascular and nervous lesions. The most important lesion is rupture of the middle meningeal artery in the foramen spinosum leading to an acute epidural haematoma. Its early diagnosis is of vital importance. Lesions of the cranial nerves are rarely surgically remediable. Diagnostic steps in the management of these lesions are outlined. Close cooperation between ENT specialists and neurosurgeons is of the highest importance, particularly when dealing with petrous bone lesions producing C.S.F. otorrhea or the prolapse appearance of contused brain into the auditory canal.

Brain Injuries↗
PubMed1985

Investigations of chromosomal stability in the Gorlin-Goltz syndrome.

Chromosomal studies were carried out on nine patients with the Gorlin-Goltz syndrome using recently developed methods on cultured lymphocytes. In addition, the dermatoglyphics of these patients were examined. No evidence of a characteristic chromosome aberration was found in banded prometaphase-chromosome preparations, nor could increased chromosome breakage be demonstrated in eight of the patients. One proposita showed frequent breaks of Chromosome 1 at p22. Increased chromosome instability in these patients was suggested by higher spontaneous and mitomycin-C-induced sister chromatid exchange rates in patients than in controls. Although the dermatoglyphic findings cannot be regarded as specific for the Gorlin-Goltz syndrome, an increased occurrence of whorl patterns and white lines in patients' fingerprints was noted.

Basal Cell Nevus Syndrome↗
PubMed1985

[Nuclear spin tomography in brain tumors. Evaluation of 40 confirmed cases].

Forty histologically confirmed primary and secondary cerebral tumours are described. These contained fifteen primary tumours, five adenomas of the hypophysis, four hamartomas or lipomas and craniopharyngiomas, three meningiomas and three vascular malformations. One malignant lymphoma, one chordoma and eight cerebral metastases were also included. In our series, the accuracy of CT and MR were the same, particularly since most patients coming for MR had abnormal CT findings. MR was superior in demonstrating vascular malformations and sometimes in the differential diagnosis of tumour versus infarct. MR is also more accurate in demonstrating the extent of a tumour and of infiltration, since it is possible to obtain images in several planes. Disadvantages of MR are related to the characterisation of primary brain tumours, since the signals from these tumours failed to show characteristic differences. Calcification cannot be recognised. In sixteen out of 36 patients, MR proved superior, whereas CT was superior in five. Tumour-related oedema was present in 18 cases and demonstrated by MR in seventeen. CT failed to differentiate tumour from oedema on one patient.

Adult↗
PubMed1984

[Monozygotic twins with Klinefelter syndrome (concordant) and systemic lupus erythematodes (discordant)].

Monozygotic twins, both with Klinefelter's syndrome, are presented. One of them had clinical and serological evidence of systemic lupus erythematosus (SLE), whereas the other did not show any immunological disorder. In relation to this case of discordant SLE the role played by exogenous factors in triggering the manifestation of this autoimmune disease under a certain genetic predisposition is discussed.

Adolescent↗
PubMed1984

Purification of the T lymphocyte growth factor interleukin-2 from culture media of human peripheral blood leukocytes (buffy coats).

Interleukin 2 was purified 100 000-fold to apparent homogeneity from the supernatants of mitogen-stimulated human blood leukocytes. A sequence of three purification steps was used: affinity chromatography on the bound dye cibacron blue, gel filtration on Ultrogel AcA44, and reversed-phase high-performance liquid chromatography on hexyl phase. The resulting interleukin 2 had a specific activity of 2 X 10(6) U/mg protein, and was free of pyrogenicity in the rabbit test. The final purification product showed two bands in sodium dodecyl sulfate/polyacrylamide gels with apparent molecular masses of 15 kDa and 17 kDa respectively. Both bands were biologically active.

Cells, Cultured↗
PubMed1984

Glycogen storage disease type Ib: familial bleeding tendency.

A mild bleeding tendency with characteristics of the von Willebrand disease was documented in family members of a girl with glycogen storage disease type Ib (GSD) Ib). It was assumed that a defective glucose-6-phosphate dependent microsomal glycoprotein synthesis was involved in the bleeding disorder of the patient and the GSD Ib heterozygotes.

Adolescent↗
PubMed1984

Prenatal diagnosis of a probable hereditary syndrome with holoprosencephaly, hydrocephaly, octodactyly, and cardiac malformations.

Following genetic counselling of a consanguineous couple because of a daughter born with peripheral hypoplasia of the left arm, ultrasonographic examination during the second pregnancy revealed marked hydrocephalus of the fetus in the 17th week of pregnancy. Pathologic examination of the female fetus disclosed severe cerebral, cardiac, and skeletal malformations including holoprosencephaly, absent corpus callosum, microphthalmia, facial clefts, tetramelic octodactyly, and cardiac defects. These findings indicate a possible genetically determined syndrome that appears to be distinct in spite of some overlap with other malformation syndromes.

Abnormalities, Multiple↗
PubMed1984

[Surgical treatment of cervical spine injuries in childhood with special reference to the morphological and functional characteristics of the cervical vertebrae].

Over a period of 13 years 26 children with cervical spine injuries were treated, aged between 3 and 16 years, corresponding to a share of 10 per cent of all cervical injuries from 1969 to 1982. Surgical stabilisation of traumatic vertebra segments was performed in 6 children because of permanent segment instabilities. In case of mobile luxations and luxation fractures, different operative treatments and special morphological and functional features of cervical spine in childhood are discussed. Clinical and radiological long-term results of early surgical stabilisation are presented.

Adolescent↗