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Biomedical subjects

W Frank

Publications and source records attributed to W Frank.

At least 91 records · Page 5Linked to original sources
PubMed1990

[Gas transfer in nonspecific inhalation provocation].

In 37 patients with clinically suspected non-specific bronchial hyperreactivity, a comparative study was performed prior to and following bronchial challenge with histamine employing the following parameters: flow-volume curve, whole-body plethysmography, single-breath spirometry, capillary blood gas analysis. Four types of reaction can be distinguished: isolated bronchial reaction, isolated gas transfer disturbance, dual reaction, no reaction. A Correlation of the induced gas transfer disturbance was found only for the flow data reflecting small airways dysfunction (Vmax 25%), but not for the basic lung function parameters. The transfer factor and transfer coefficient are insensitive and, on average, show only small, non-directed changes.

Adult↗
PubMed1990

First report on the occurrence of human cases of alveolar echinococcosis in the northeast of Austria.

Since Posselt (1928) it is known, that Echinococcus multilocularis, the causative organism of alveolar echinococcosis, is prevalent in the western and southern provinces of Austria (Vorarlberg, The Tyrol, Salzburg, Carinthia, Styria). Recent distributional data confirmed the existence of these endemic areas in the mountain range of the Alps. Within the period from 1983 to 1988 human cases of obviously autochthonous alveolar echinococcosis were detected in the northeast of Austria, north of the river Danube, for the first time. This paper presents a clinical, diagnostic, therapeutical and epidemiological documentation of these three cases (2 females, 1 male), which represent the eastern most records of autochthonous E. multilocularis infections of the Central European distribution area of alveolar echinococcosis.

Austria↗
PubMed1989

Echinococcus multilocularis: in vitro secretion of antigen by hybridomas from metacestode germinal cells and murine tumor cells.

Hybrid cells were produced from Echinococcus multilocularis metacestode germinal cells and murine tumor cells. Small colonies were formed which, while ceasing to grow after a few generations, remained viable for at least 10 weeks. These hybridoma cells secrete antigen(s) reacting in indirect immunofluorescence and ELISA specifically with sera from patients suffering from an E. multilocularis infection. The antigen(s) appear suitable for the differential diagnosis of E. multilocularis and E. granulosus. Thus, hybridoma cells may produce helminth antigens.

Animals↗
PubMed1989

Comparison between continuous and intermittent infusion regimens of cimetidine in ulcer patients.

The relative effectiveness of intermittent infusions and primed continuous infusions of cimetidine in the maintenance of intragastric pH greater than or equal to 4.0 was evaluated in a double-blind crossover trial in 26 patients who had active or healed gastroduodenal ulcers. During the intermittent phase, each patient received 300 mg cimetidine intravenously every 6 hours. During the continuous infusion phase, each patient was given a continuous infusion of 37.5 mg cimetidine per hour, preceded by a priming dose of 300 mg cimetidine that was given for 15 minutes. Intragastric pH was monitored continuously. During the last 12 hours of the study, the continuous infusion regimen provided 20% more time in which the pH was more [corrected] than 4.0 with 25% less medication than did the intermittent infusion regimen.

Adolescent↗
PubMed1989

[Sonographic staging of pancreatic cancer. Report of 100 cases].

The ultrasound studies of 100 patients with proven pancreatic carcinoma were reviewed and correlated with the intraoperative and pathoanatomic findings. Ultrasound had a sensitivity of 87% in detecting the malignant lesion. The extension of the tumour and the infiltration of peripancreatic structures and visceral vessels was interpreted correctly in 85% of the cases. The sensitivity for liver metastases was 90.9%, whereas for lymph node involvement it was 78.3%. 19 patients had carcinosis peritonei. Ultrasonography could only detect the carcinosis in two cases. Malignant ascites was found in 15% (sensitivity of US 88.2%). 31% of the pancreatic carcinomas were resectable.

Adult↗
PubMed1989

[Sonography of gallbladder carcinoma. Correlation with surgical findings in 60 cases].

60 patients with carcinoma of the gallbladder were staged preoperatively by sonography (staging scheme by Nevin and TNM scheme of the UICC). This was correlated with the operative and histopathological findings. The tumour was diagnosed by sonography in 70% of the patients, 15% were diagnosed at operation and 15% histopathologically. The criterion for malignancy was tumour invasion into the liver (94.7% Sensitivity) and/or into adjacent tissues (36.8% Sensitivity). Most tumours were in an advanced stage (98.5%) and only one early carcinoma (1.5%) was found histopathologically. No improvement in the diagnosis of early carcinomas was achieved by ultrasound in our series.

Adult↗
PubMed1989

[Pleurodesis with tetracycline hydrochloride].

Malignant pleural effusion is a common complication of malignant disease requiring drainage and palliative sclerosing therapy in the vast majority of cases. Tetracycline in conjunction with thoracoscopic drainage is currently considered as the optimal sclerosing agent due to its high efficacy, good patient tolerance, simple and repeatable applicability and low cost of treatment. Traditional and more recent agents like fibrin-sealant may give similar results, but do not achieve a favourable all-round-properties. The relevant data from the literature are reviewed, our own results are presented. An explicit description of pleurodesis is given, also a brief discussion of possible mechanisms of action of sclerosing agents. Concepts are suggested for positioning pleurodesis in the general therapeutic approach to various tumours. The concept of pleurodesis can be similarly successful and safely applied on malignant pericardial effusion (pericardesis).

Drainage↗
PubMed1989

[Fibrosing mediastinitis].

Fibrosing mediastinitis is a rare entity either idiopathic or caused by granulomatous disease. Plain film findings mainly show widening of the upper half of the anterior mediastinum, whereas CT delineates more clearly the exact location of the mediastinal mass and the extent of compromise of mediastinal structures. Although vessels surrounded by the fibrous mass are typically smoothly bordered and only rarely displaced, diagnosis can only be suspected together with the patients history and clinical course.

Adult↗
PubMed1987

[Sonography of acute cholecystitis. A report on 58 cases with a correlation of pathomorphological and histological findings].

Sonography has become the method of choice for evaluating acute diseases of the right upper quadrant. Prior to the ultrasound the diagnosis of acute cholecystitis was based on clinical and laboratory data. The pathohistomorphology of 58 opertively and histologically proven cases of acute cholecystitis has been correlated with preoperative sonography. An acute cholecystitis can be diagnosed based on the following sonographic criteria: Thickening of the wall of the gallbladder to more than 4 mm, sonolucent areas in or around the wall of the gallbladder, an increased ap. diameter of more than 4 cm as well as gallstones. A hyperechoic content of the gallbladder correlating to an empyema of the gallbladder was found in 31% and a perforation in 27.6% of the cases.

Acute Disease↗
PubMed1987

[Functional choledochus diagnosis following cholecystectomy].

50 patients after cholecystectomy and right upper quadrant pain have been examined by ultrasound for obstructive biliary disease. The value of dynamic changes of the common hepatic duct after a fatty meal in the evaluation of bile duct obstruction was investigated. The accuracy of a negative test in the group of patients with normal bile ducts (n = 27) was 100%. However in patients with dilated bile ducts (n = 23) the value of this test is limited. In this group 3 false negatives in patients with multiple small moveable stones occurred resulting in an accuracy of 86.9%.

Cholangiography↗