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Biomedical subjects

V G Kukes

Publications and source records attributed to V G Kukes.

At least 73 records · Page 4Linked to original sources
PubMed1982

[Use of the new hypotensive agent Minipress (prazosin hydrochloride].

Efficacy of minipress in patients with hypertension stage II and its haemodynamic effects were studied after a single administration and during a course of treatment. It is shown that its main mechanism is in vasodilatation caused by relaxation of the muscular component of arterioles. The authors suggest that minipress can produce redistribution of the blood through peripheral venoconstriction. Decrease of the index of the external work of the heart points indirectly to decreased oxygen utilization by the myocardium which may reflect changes in haemodynamics under the influence of minipress or through direct action of the drug on the heart. Hypotensive effect of minipress is recorded already by the 5th day of its administration (p less than 0.001), however, its further effect is unstable. Increase of the circadian dose becomes necessary and also its combined use with thiazide diuretics. Positive chronotropic effect of Minipress has been recorded, with maximum towards the end of the 2nd week of treatment and seen as increased rate of cardiac contractions by 13.2% (p less than 0.01). To decrease this effect authors advise to use minipress in combination with beta-adrenoblockers.

Adult↗
PubMed1979

[Use of phosphaden in treating chronic ischemic heart disease].

The pharmacodynamics and pharmacotherapy of phosphaden (adenosine-5-monophosphate), a Soviet activator of energy metabolism, were studied in patients with chronic ischemic heart disease. Functional and biochemical methods were used. It was established that phosphaden is an effective drug in the treatment of chronic ischemic heart disease. The results of clinical, functional and biochemical examination support this conclusion.

Adenosine Monophosphate↗
PubMed1978

[Mechanism of action and clinical effectiveness of the new Soviet-made drug parmidin in the treatment of arteriosclerosis and ischemic heart disease].

The pharmacodynamics and efficacy of the new Soviet drug parmidin depending on the state of the coronary reserve are discussed on the basis of the results of observation over 176 patients suffering from chronic ischemic heart disease with affection of the peripheral arteries of the lower extremities. The activity of the drug in patients with atherosclerotic and diabetic affection of the arterial vessels is shown. The pharmacokinetics of parmidin in patients after the administration of a single 1.0 g dose was studied by determining its content in blood and urine 1, 2, 4, 8, 12, and 24 hours later. The effect of parmidin on the blood kinin system in patients with chronic ischemic heart disease was studied.

Adolescent↗
PubMed1978

[Use of the preparation Essenciale in chronic ischemic heart disease].

The efficacy of the drug "essentiale" is discussed on the basis of observation over 34 patients suffering from ischemic heart disease with functional hepatic insufficiency and types IIa and IIb hyperlipoproteinemia. Its normalizing effect on the indices of lipid metabolism the flow of blood in the leg and foot, the vascular tone, and liver function is shwon.

Aged↗