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Biomedical subjects

V G Kukes

Publications and source records attributed to V G Kukes.

At least 55 records · Page 3Linked to original sources
PubMed1986

Derivatization of endogenous and exogenous compounds in plasma for high-performance liquid chromatographic analysis.

Methods are described for the analysis of endogenous (acetoacetic and pyruvic acids) and exogenous (propranolol) compounds in plasma. Acetoacetic and pyruvic acids were converted into 2,4-dinitrophenylhydrazones and identified by chromatography on a normal-phase silica gel column at 360 nm. The propranolol amino group was modified with dansyl chloride and the dansyl derivative, after extraction with a hydrophobic solvent, was analysed on a normal-phase silica gel column using fluorescence detection. The method allows the determination of 0.5 ng/ml of propranolol.

Acetoacetates↗
PubMed1985

[Comparison of the results of ethacizin pharmacodynamics and pharmacokinetics in a single intravenous administration].

A single intravenous injection of 30-50 mg ethacizin produces a favourable antiarrhythmic effect in 80-85% of patients with ventricular disorders of cardiac rhythm. The drug's action already begins "on the needle", reaches its peak within 3-5 minutes and lasts for 1-2 hours. A two-compartment model adequately represents ethacizin pharmacokinetics. The average ethacizin half-distribution and half-elimination periods are 4.7 and 154.4 minutes, respectively, and its clearance rate is 0.99 1/min. Therapeutic plasma concentration of the drug varies between 30-50 and 300-400 ng/ml.

Adolescent↗
PubMed1984

[Features of myocardial metabolism of adenylic nucleotides in patients with paroxysmal tachycardias].

The authors revealed that concentrations of inosin, hypoxanthine and their total levels in the arterial blood and the blood of the coronary sinus in patients with paroxysmal tachycardias are higher than the corresponding levels in patients with chronic forms of coronary heart disease and neurocirculatory dystonia. In the absence of tachycardia, there was an accelerated metabolism of adenyl nucleotides of the myocardium: the myocardium produced inosin and extracted hypoxanthine. It is suggested that this type of metabolism of adenyl nucleotides requires additional energy expenditures as compared with the energy supply of the nucleotide metabolism of the healthy myocardium and may be one of the reasons underlying the development of tachycardiac paroxysm, with the place of the localization of the re-entry and/or the presence of coronary heart disease having no significant effect on the metabolism of adenyl nucleotides of the myocardium in such patients. The emergence of tachycardia leads to a decreased extraction of hypoxanthine by the myocardium as compared to the baseline and to insignificant elevation in the production of inosin which causes an increase in the levels of these metabolites in the arterial blood and the blood of the coronary sinus.

Adenine Nucleotides↗
PubMed1984

[Drug interaction].

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Biological Availability↗
PubMed1984

[Effect of myocardial ischemia on adenine nucleotide metabolism].

Patients with coronary heart disease (CHD), neurocirculatory dystonia and acute myocardial infarction showed statistically significant, positive linear correlations between the levels of inosine and hypoxanthine as well as the total concentration in the arterial blood and the blood from the coronary sinus. The correlation analysis ascertained that CHD patients in the initial state exhibited a considerable extraction of inosine by the myocardium as compared to patients with neurocirculatory dystonia and that in electrically stimulated ischemia it was sharply reduced. Electrostimulation in the group of patients with neurocirculatory dystonia had no effect on the rate of inosine extraction. Acute myocardial infarction was related to a higher rate of inosine extraction and to inosine production in the myocardium, the latter being explained by the degradation of adenyl nucleotides in conditions of acute ischemia. It is outlined that the total level of inosine and hypoxanthine in the arterial blood of patients with acute myocardial infarction may indicate the severity of infarction while its variations over time may be prognostically valuable.

Adenine Nucleotides↗
PubMed1983

[A new Soviet drug, ethacizine, in the treatment of ventricular rhythm disorders].

The intravenous form of the Soviet anti-arrhythmic pharmaceutical ethacizine has been studied clinically. The pharmaceutical was administered to 30 patients with ventricular rhythm disorders during 3 to 15 minutes, at an average dose of 0.63 mg per 1 kg body weight, under the Holter monitor control. On the average the effect became apparent 6.5 min, after the injection and lasted on the average 149 +/- 15 min. Etacizine was effective in 77% of cases. It was established that there was no pronounced negative effect on the heart rate and the arterial pressure. Uzineg the tetrapolar rheography method it was shown that there was no pronounced negative effect on the central hemodynamics. The observation was made that etacizine induced a moderate decrease of the conductivity in atria AV-system and ventricles. Etacisin could be successfully used for rapid suppression of the ventricle rhythm disorders in various forms of coronary disease of the heart.

Adult↗