Search PubMed⌕ Search

Biomedical subjects

V G Kukes

Publications and source records attributed to V G Kukes.

At least 37 records · Page 2Linked to original sources
PubMed1993

[The pharmacodynamics of theophylline (euphylline)].

A single intravenous administration of 2.4%-10.0 euphylline to 35 patients with obstructive affections of the lungs entailed a broncholytic effect in large airways in patients with reversible obstruction under sub-therapeutical theophylline concentrations in the serum. In patients with mixed type of the obstruction and restrictive disturbances ineffective ventilation got worse, ventilation-perfusion relations disagreed, hemoglobin affinity to oxygen grew, pulmonary artery pressure dropped against the signs of pulmonary hypertension, EEG changed according to asynchronism pattern corresponding to brain hyperactivity. There was also elevation of both norepinephrine and epinephrine serum levels due to slow parenchymatous hepatic circulation which inhibited clearance of the substances. There was no relationship between changes in the indices and theophylline concentrations in the range 3.8-8.8 micrograms/ml.

Adult↗
PubMed1993

[The pharmacokinetic characteristics of theophylline in patients with chronic nonspecific intestinal diseases in relation to its routes of administration into the gastrointestinal tract].

Theophylline pharmacokinetics was investigated upon introduction of euphylline (0.15 g) at four levels of gastrointestinal tract: orally (20 patients), into the jejunum (15 patients) at enterogastroduodenoscopy, in the ileocecal area (8 patients) at colonoscopy and rectally (9 patients). Absorption speed depended on the variant of the gastrointestinal introduction rather than on the variant of chronic nonspecific intestinal disease, and appeared maximal in the drug introduction into the jejunum. Concentration and area under curve became maximal in minor participation of the liver in primary capture and biotransformation of theophylline. Reduced theophylline doses are recommended in lower hepatic metabolism of the drug, in hepatic hypofunction, in rectal route of administration.

Administration, Rectal↗
PubMed1990

[The clinical pharmacology and efficacy of the new Soviet calcium antagonist foridon].

A total of 56 patients with coronary heart disease (CHD), angina pectoris of effort, functional classes II-III, were placed under observation. All the patients received 20 mg foridon (F), 20 mg corinfar (C), 80 mg anapriline (A). 24 patients were subjected to the continuous treatment with F (20 mg 4 times a day). The antianginal action of the drug was compared to the blood concentration on days 7, 14, 21, 28, 43 and 57 of the treatment with F. In 14 patients with angina pectoris and in 18 patients with essential hypertension, the efficacy of F and C was cross correlated. It has been demonstrated that F can be successfully used for the treatment of patients with CHD, angina pectoris of effort and (or) essential hypertension. The increase of the single dose of foridon from 20 to 40 mg does not result in the potentiation of its hypotensive effect. F and C provoke the highest rise of exercise tolerance with combined angina pectoris. Continuous concomitant administration of F and C with A leads to the potentiation of the antianginal action.

Angina Pectoris↗
PubMed1990

[Pharmacodynamics, pharmacokinetics and clinical effectiveness of captopril in patients with hypertension].

Captopril was tested for pharmacokinetics. Its hypotensive effect was compared with plasma renin activity (PRA) and blood captopril levels in single and prolonged administrations of its various doses in 58 hypertensive patients. When a single dose (25 mg) of captopril was given, a relationship was found between its hypotensive effect and higher blood concentration, baseline PRA. The detection rate of its antihypertensive effect was not related to the baseline PRA. The efficient and safe dose of captopril was shown to be 75-150 mg daily, maintaining its blood concentration within ranges of 75-175 ng/ml.

Aged↗
PubMed1990

[Ethmozine pharmacokinetics in liver insufficiency].

The authors' findings permit a conclusion that the risk of ethmozine overdosage leading to undesirable side effects (dryness in the mouth, noise in the ears, a 'net' in eyes; giddiness, nausea, vomiting) is very high when routine ethmozine doses are administered to patients with grave (Stages II-III) impairments of liver function; this is explained by (1) reduced rate of ethmozine biotransformation, this resulting in a heightened concentration of the drug in the blood, and (2) by an increase of the drug free fraction concentration due to its reduced ability to bind with the blood plasma proteins. This necessitates a pharmacokinetic monitoring of such patients prescribed ethmozine and a correction of the drug dose, if necessary.

Anti-Arrhythmia Agents↗
PubMed1989

[Hemoglobin affinity to oxygen and its correction with captopril in chronic cardiac insufficiency].

Blood gaseous composition, mechanisms controlling hemoglobin affinity to oxygen and hemoglobin effects of a single captopril dose were assessed in 124 patients with chronic heart failure (CHF). CHF-associated hypoxemia was shown to be mixed, with the circulatory component prevailing. Hemoglobin affinity to oxygen is increased in CHF, stage IIA, and reduced in CHF, stages IIB-III. 2,3-diphosphoglycerate is the principal regulator of hemoglobin affinity to oxygen its blood level increasing progressively as CHF aggravates. Hemoglobin affinity to oxygen may be reduced by captopril in patients with CHF of stages I-IIA.

2,3-Diphosphoglycerate↗
PubMed1989

[Pharmacologic effects of peripheral vasodilators in patients with secondary pulmonary hypertension].

A single dose of capoten (25 mg) and prazosin (I mg) was given to 82 patients with stable pulmonary hypertension and chronic non-specific pulmonary diseases and to 34 patients with the above condition and arterial hypertension. Systolic and diastolic pressure in the system of the pulmonary artery and total pulmonary and total peripheral resistance were decreased; capoten exhibited more pronounced hypotensive effect. Unidirectional changes were revealed in the course treatment. Combined use of capoten, prazosin and euphilline produced the additional hypotensive effect on pulmonary circulation. Capoten and prazosin had no direct broncholytic effect.

Adolescent↗
PubMed1988

[Clinical pharmacology of the new Soviet anti-inflammatory preparation ortofen].

Comparative pharmacokinetic and pharmacodynamic studies on ortophen, a new Soviet antiinflammatory drug, and voltaren (Ciba-Geigy, Switzerland) were carried out in 73 patients with rheumatoid arthritis. Pharmacokinetics of both drugs was studied in 19 patients (9 patients were given voltaren, 10--ortophen). Pharmacokinetic difference was statistically indistinguishable. The comparison of the principal routine subjective and objective pharmacodynamic indices revealed no significant difference between ortophen and voltaren action. The new drug was shown to possess a high analgetic and antiinflammatory activity.

Arthritis, Rheumatoid↗
PubMed1988

[Premorbid characteristics and nature of the mental disorders in patients with neurocirculatory dystonia and heart rhythm disorders (clinico-psychological research)].

Forty-two patients with different types of functional cardiac arrhythmias were examined. Clinico-psychological examination revealed such general and relatively independent of the personality type features as conservatism, predisposition to anxiety reactions, hypochondriac readiness, symptomatic lability, poor self confidence in relation to interpersonal interrelations, poorly expressed ability to dominate with a tendency toward submission. Neurotic reactions and phases were a predominant feature in accentuated (n = 20) and psychopathic persons (n = 10). Slowly progressive schizophrenia and cyclothymia were diagnosed in 8 and 4 cases respectively. Treatment of functional cardiac arrhythmias with lexotan yielded good response in 50% of cases. In cases when lexotan alone failed to be effective, the use of this drug in combination with antiarrhythmic drugs effected good results in 61.8% of the patients.

Adult↗