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Biomedical subjects

U Kaur

Publications and source records attributed to U Kaur.

At least 55 records · Page 3Linked to original sources
PubMed1987

Adult onset Still's disease in North India. A report on six patients.

Six patients suffering from adult onset of Still's disease were seen over a 10-year period. Contrary to expectations, complications of deformative arthritis (two patients), amyloidosis (one patient), uveitis (one patient) and chronic granulomatous liver disease (one patient) were observed during follow-up. One patient succumbed due to iatrogenic causes; autopsy showed that the pathological changes, like the clinical features, were non-specific. Four patients responded to aspirin and indomethacin; two required corticosteroids.

Adolescent↗
PubMed1987

Anorexia nervosa in a patient with systemic lupus erythematosus.

Anorexia nervosa has not been described in patients with systemic lupus erythematosus (SLE). The case of a patient with SLE who developed the classical features of anorexia nervosa is described. Although an impressive interplay between psychosocial and cultural factors was present, the possibility that this syndrome was produced by active CNS vasculitis remained.

Adolescent↗
PubMed1987

Wegener's granulomatosis in north India. An analysis of eleven patients.

Eleven patients with Wegener's granulomatosis were seen at this Institute over a period of 20 years. There were six men and five women. The average age of presentation was 38.3 years, and the mean duration of symptoms was 10.5 months. Constitutional symptoms (82%), cough (82%), ocular symptoms (64%), arthralgias (55%), rhinorrhoea (55%), haemoptysis (45%), nasal granuloma (45%), otorrhoea (36%), sinusitis (36%), skin lesions (27%), and renal failure (27%) were the clinical manifestations encountered. All patients had an elevated ESR, and 55% had leucocytosis. Proteinuria and haematuria were observed in 64% and 55% respectively. Chest radiographs were abnormal in 82%. In four patients the disease had a fulminant course and the patients died before adequate treatment was given. Two patients received corticosteroids alone and have since been lost to follow up. Five (45%) received adequate cytotoxic therapy and have done well for 8-46 months (mean, 24.8 months) after diagnosis. Wegener's granulomatosis in India is apparently similar to that seen elsewhere, but the high incidence of tuberculosis interferes with early diagnosis and treatment.

Adolescent↗
PubMed1987

Sarcoidosis in north India: the clinical profile of 40 patients.

Sarcoidosis is being increasingly recognized in India. Over the last 7 years we studied 40 patients. Older males out numbered young females. Thoracic (98%), constitutional (50%) and ocular (40%) involvement dominated the clinical profile. In addition, erythema nodosum (20%), facial palsy (13%), parotid enlargement (8%), lymphadenopathy (42%), hepatomegaly (37%) and splenomegaly (17%) were also observed. Radiologically, 53%, 30% and 15% of patients were in Stage I, II and III respectively at presentation. Kveim test was positive in 45% of those tested. The diagnosis was histologically confirmed in 80% of patients. The remaining eight patients (20%) were relatively asymptomatic, all had bilateral hilar lymphadenopathy and either erythema nodosum or uveitis or both. 88% were tuberculin negative. Systemic steroids were used in 60% and topical steroid eye drops in a further 20%. Response to therapy was excellent except in Stage III disease where radiological and spirometric deterioration was observed in three patients. There were no fatalities. The overall clinical behaviour of north Indian patients with sarcoidosis was quite similar to that of patients in England but different from previously reported Indian patients.

Adrenal Cortex Hormones↗
PubMed1986

Guillain-Barré syndrome. A clinical electrophysiological and biochemical study.

Fifty-six consecutive patients with Guillain-Barré syndrome representing 49% of all cases of peripheral neuropathy (except those due to diabetes mellitus and leprosy) admitted to the Postgraduate Institute of Medical Education and Research, Chandigarh over a period of three years were studied. All patients developed weakness of limbs within one day to three weeks. Attenuation of deep tendon jerks (98%) paresthesia (66%), cranial nerve involvement (41%) and antecedent infection (32%) were the common clinical features. The common patterns of motor weakness were predominantly proximal in all the four limbs (45%) or predominantly proximal in lower limbs along with distal muscles in upper limbs (29%). Electrodiagnostic studies revealed prolonged distal (motor) latency (82%), reduced motor nerve conduction velocity (74%), sensory nerve conduction abnormality (85%) and evidence of denervation (41%). Evoked motor response of median, ulnar, common peroneal and tibial nerves exhibited significant increase in duration and reduction in amplitude. The maximum incidence of electrophysiological abnormality occurred between four to 12 weeks after the onset of neurological symptoms. Four patients died and 11 showed poor recovery. Long intervals (greater than 3 weeks) between peak deficit and onset of recovery and coexistence of reduced motor nerve conduction velocity with evidence of denervation on EMG were found to be associated with poor recovery.

Adolescent↗
PubMed1986

An outbreak of typhoid fever in Chandigarh, North India.

An outbreak of typhoid fever occurred among 54 hospital nurses after a picnic. The salient features were fever (100%), nausea and vomiting (46%), loose motions and abdominal pain (13%), and palpable splenomegaly (63%). None of the patients had any major complications. Blood cultures for Salmonella typhi were positive in 81%, blood Widal was positive (1:320 or more) in 43% and suggestive (1:160) in 25% of the blood culture positive patients. A comparable number of patients were administered chloramphenicol or co-trimoxazole and no differences in response were observed. Bacteriological examination of samples of water from the likely sources revealed it to be unfit for human consumption due to gross faecal contamination.

Adolescent↗
PubMed1982

Meningioma presenting as recurrent transient cerebral ischemia and intracranial hemorrhage.

Intracranial tumors are sometimes known to appear first as apoplexy. This report describes a patient with a meningioma of the falx who experienced acute onset of symptoms due to intracerebral and subarachnoid hemorrhage and following a history of transient ischemic attacks on exertion. The tumor was an angioblastic-meningioma. The probably source of bleeding and the mechanism of transient ischemic episodes provoked by exertion are discussed.

Adult↗
PubMed1981

Cysticerciasis and epilepsy: a clinical and serological study.

Study of 1,038 randomly selected cases of epilepsy in Chandigarh showed the cysticercus haemagglutination test to be a useful adjunct in the diagnosis of cysticerciasis as an aetiological factor. It was positive in 25.7% of epilepsy cases but in only 2% of healthy controls. The rate of seropositivity was higher in focal than in generalized epilepsy although the difference was not statistically significant. Incidence of seropositivity was about equal in males and females but did not appear to be related to the duration of epilepsy.

Adolescent↗
PubMed1977

Effect of selective depletion of fibrinogen on the evolution of cholesterol-induced atherosclerosis in rabbits.

Atherosclerosis was produced by induced alimentary hyperlipaemia in four groups of rabbits. Animals of groups II and III received cholesterol feeds daily for 2 months while in groups IV and V this was followed by another 3 months of intermittent feeding. Group I comprised normal control rabbits. Selective fibrinogen depletion was produced in groups III and V with Arvin so as to maintain the plasma fibrinogen around 100 mg/dl over the last 2 months of cholesterol feeding. Serum lipids, blood coagulation and euglobulin clot lysis as well as the post mortem histopathology of aorta, heart, kidneys, liver and lungs did not reveal any significant differences between corresponding groups of hyperlipaemic animals treated with (groups III and V) or without (groups II and IV) Arvin. It appears that fibrinogen or fibrin incorporation does not play a significant role in the pathogenesis of atherosclerotic lesions induced in rabbits by cholesterol feeding.

Afibrinogenemia↗
PubMedDate not supplied

Evaluation of newer diagnostic methods for the detection and differentiation of Entamoeba histolytica in an endemic area.

We evaluated the colorimetric polymerase chain reaction (PCR)-based method for the detection and differentiation of Entamoeba spp. and compared the efficacy of E. histolytica-specific antigen detection in faeces with the detection of specific antibodies to E. histolytica-specific antigen in faeces, by enzyme-linked immunosorbent assay. Faecal samples were obtained from patients attending hospital in Chandigarh, India, from March 2001 to February 2002. The PCR-based colorimetric method was found to be the most sensitive (100%) and it could differentiate between pathogenic and non-pathogenic Entamoeba spp. The present study also emphasized that the antigen detection system may prove to be a better diagnostic tool than the antibody detection system in endemic areas.

Animals↗
PubMedDate not supplied

Percutaneous liver biopsy: a safe outpatient procedure.

Percutaneous liver biopsy with Menghini or Trucut needle as an outpatient procedure was performed on 159 patients over a 3.5-year period. No major complications were observed. Liver biopsy is recommended as an outpatient procedure, which would reduce the patient load on limited hospital beds and economize on the hospital resources.

Ambulatory Care↗
PubMedDate not supplied

Hepatic-pericardio-phrenic collateral (natural shunt) in a patient with Budd-Chiari syndrome.

Hepatic venous outflow tract obstruction, Budd-Chiari syndrome (BCS), leads to portal hypertension and to the development of collaterals that bypass the obstruction. Described here is a BCS patient with an unusually large transdiaphragmatic collateral between the left hepatic and left innominate veins, which decompressed the oesophageal varices. This has not been reported earlier in the literature.

Adult↗