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Biomedical subjects

U Braun

Publications and source records attributed to U Braun.

At least 325 records · Page 18Linked to original sources
PubMed1978

An iodinated catecholamine congener for brain imaging and metabolic studies.

The iodinated O-methylated catecholamine congener, 4-iodo-2,5-dimethoxyphenylisopropylamine (4-I-DPIA), has potential as a new agent for imaging and metabolic studies of the brain and lung. The organ distribution and brain uptake of radioiodine-labeled 4-I-DPIA were studied in the dog and monkey by whole-body scanning, gamma-camera scintigraphy, and organ assay. The brain takes up 2% of the injected dose, with a half-time of 8 sec in the monkey, and the lung takes up 11.8%. An unusual finding was a concentration in the retina, five times that in any other CNS tissue. 4-I-DPIA may have potential in the imaging of normal brain tissues and thereby delineating nonfunctional areas damaged by infarction, trauma, or malignancy, and may also be useful in metabolic studies of catecholamine function. Adequate radioactivity can theoretically be administered with a quantity of 4-I-DPIA 1/10,000 of the pharmacologically active levels. The agent may also find application in lung imaging because of the high pulmonary uptake.

Amphetamines↗
PubMed1978

[The role of ventilatory disturbances in the late postoperative hypoxaemia after upper abdominal surgery. A contribution to the risk of upper abdominal surgery in patients with respiratory damage (author's transl)].

The purpose of our investigations was to evaluate the influence of disturbed inspiratory gas distribution on postoperative hypoxemia in patients with abnormal lung function undergoing upper abdominal surgery. The lung function analyzer Hewlett-Packard 47402 A was used (Volume-time and flow-volume curves of forced expiration, single and multiple breath nitrogen washout tests with indices of ventilatory gas distribution). It was demonstrated that postoperative hypoxaemia in the undamaged lung is almost exclusively the result of augmented true right to left shunt. In patients with abnormal lung function the cause of postoperative hypoxaemia is, for the most part, an increase of disturbances of ventilatory gas distribution. These changes in the postoperative period can be explained by a reduction of FRC, that follows from changing of position (sitting-lying) and from pain. In patients with borderline lung function this reduction of FRC postoperatively may limit surgical treatment. The management of pain is of great importance in these patients. Continuous epidural anaesthesia certainly produces the best results in this respect.

Abdomen↗
PubMed1977

Synthesis and body distribution of several iodine-131 labeled centrally acting drugs.

1-(4-iodo-2,5-dimethoxyphenyl)-2-aminopropane (3B), 4-iodo-2,5-dimethoxyphenylethylamine (3A), and 1-(4-iodo-2,5, dimethoxyhenyl)-2-aminobutane (3C) have been synthesized with 131I. Labeled iodine monochloride reacts with the appropriately substituted phthalimide at the aromatic 4 position, and the phthalic acid group is removed with hydrazine. Body distribution was measured in rats; the most prominent difference between the three compounds was a much greater concentration in the lung with 3b than with 3a or 3c. gamma-Ray scintigraphs of 3a-c in rats and of 3b in a dog indicate an uptake by the brain similar to that of the bromine analogue of 3b (DOB) in humans. [82Br]-DOB has been suggested as a potential brain scanning agent for nuclear medicine; 3b would have the advantage over DOB of providing the superior gamma-ray imaging properties of 131I or 123I.

Animals↗
PubMed1976

[Closing volume and ventilatory distribution disturbances (author's transl)].

Ventilatory disturbances are induced by airway closure associated with an increase of the venous admixture from alveoli with a low ventilation-perfusion-ratio. Closing volume was measured by single breath nitrogen washout curves and correlated with ventilatory disturbances derived from multiple breath nitrogen washout curves and an inspiratory gas distribution index (IDI). There was present a close correlation between the closing volume in relation to the functional residual capacity and the IDI. With rising closing volume in relation to functional residual capacity a deterioration of the inspiratory gas distribution with increasing venous admixture was observed.

Adolescent↗
PubMed1975

[Disturbances of ventilatory distribution as a cause of postoperative hypoxemia after cardio-thoracic surgery (author's transl)].

In a group of 21 patients with thoracotomy the lung function was investigated pre-and postoperatively with particular consideration to N2-clearance. From the N2-clearance an Inspiratory Gas Distribution Index (IDI) is derived. This Index allows in combination with blood gas analysis an interpretation of ventilatory disturbances in the lung.

Blood Gas Analysis↗
PubMed1975

[Suppression of concomitant thrombosis in central venous catheters (infraclavicular route) by salicylates (author's transl)].

The antithrombogenetic effects of salicylates (Colfarit) were studied to determine whether thrombosis due to the catheter could be reduced. 50 patients with vena-cavacatheters (infraclavicular route) were examined by phlebography. 25 patients received no antithrombotic medications and served as the control group. In these cases 35% showed evidence of thrombus formation. The remaining 25 patients received salicylates. By this measure catheter-induced thrombosis was reduced by 67%.

Adolescent↗