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Biomedical subjects

T Tsuji

Publications and source records attributed to T Tsuji.

At least 973 records · Page 54Linked to original sources
PubMed1987

Vasoconstrictor mechanism of 5-hydroxytryptamine in isolated and perfused canine basilar arteries.

The stainless steel cannula inserting method was applied to investigate the vasoconstrictor mechanism of 5-hydroxytryptamine (5-HT) in isolated and perfused canine basilar arteries. An intraluminal administration of 5-HT induced vasoconstriction in a dose-dependent manner. Pretreatment with ketanserin, a specific 5-HT2 inhibitor, and with methysergide, a mixed 5-HT inhibitor blocked the vasoconstriction induced by 5-HT. Pretreatment with diltiazem, a potent calcium antagonist, also definitely depressed the vasoconstriction by 5-HT, as well as that by potassium chloride (KCl). The endothelial removal by intraluminal saponin treatment little influenced vasoconstriction by 5-HT. It is concluded that 5-HT-induced vasoconstriction of canine basilar arteries may be in part due to the stimulation of 5-HT2 receptors, which activate an intracellular calcium movement, rather than the influx from the extracellular space.

Animals↗
PubMed1987

A case of aneurysmal calcification within seventeen years.

A case is reported in which an aneurysm on the anterior communicating artery calcified during the time course of 17 years. A ring-like calcification was demonstrated in plain skull films as well as CT scans. Carotid angiograms showed that the aneurysm grew a little bit bigger for 17 years. The aneurysm was coated because of the calcified aneurysm.

Adult↗
PubMed1987

[Synchronous early double cancers of the stomach and gallbladder].

Presented is a case of a 76-year-old male who had a double cancer, in the stomach and the gall bladder. The gastric tumor was found to be a IIc early cancer that showed invasion into the submucosa, and was, histologically, tubular adenocarcinoma. The carcinoma of the gall bladder was limited to the mucosal layer, and was, histologically a papillary adenocarcinoma. Partial gastrectomy and cholecystectomy were performed. In a review of the literature in Japan, synchronous double cancer, an early gastric cancer and an early carcinoma of the gall bladder, is very rare and 3 only cases have been summarized, including this case.

Adenocarcinoma↗
PubMed1987

Immunoglobulin M antibody to hepatitis B core antigen (IgM anti-HBc) as a marker of interferon therapy in patients with persistent hepatitis B virus infection.

Immunoglobulin M antibody to hepatitis B core antigen (IgM anti-HBc) was measured by radioimmunoassay in the sera of 96 HBV carriers. IgM anti-HBc was detected in 17 of 66 patients with chronic active hepatitis and in 4 of 11 with liver cirrhosis. This antibody was not present in asymptomatic carriers or in patients with chronic persistent hepatitis. Testing of sequential samples revealed that the presence of IgM anti-HBc indicated active replication of HBV and at the same time an immune response to the virus. The relationship between IgM anti-HBc and the response to interferon (IFN) therapy was also studied. Results showed that IgM anti-HBc is a useful marker of the efficacy of interferon therapy.

Carrier State↗
PubMed1986

Carbohydrate structures of bovine submaxillary mucin.

The structures of carbohydrate chains derived from bovine submaxillary mucin (BSM) were investigated. Oligosaccharide-alditols released from BSM by alkaline borohydride treatment were separated into three acidic (A-1-A-3) and five neutral (N-1-N-5) oligosaccharide-alditol fractions by liquid chromatography on columns of an ion-exchange resin and Bio-Gel P-4. On the basis of the data obtained on compositional and methylation analyses, and digestion by exoglycosidase, the following structures were assigned to these oligosaccharide-alditols: A-1, alpha-NeuAc (or NeuGc)-(2----6)-GalNAc-ol; A-2, beta-Gal-(1----3)-[alpha-NeuAc-(2----6)]-GalNAc-ol; A-3, beta-GlcNAc-(1----3)-[alpha-NeuAc-(2----6)]-GalNAc-ol; N-1, GalNAc-ol; N-2, beta-Gal-(1----3)-GalNAc-ol; N-3, beta-GlcNAc-(1----3)-GalNAc-ol; N-4, beta-Gal-(1----3)-[beta-GlcNAc-(1----6)]-GalNAc-ol; and N-5, alpha-Fuc-(1----2)-beta-Gal-(1----3)-[beta-GlcNAc-(1----6)]-GalNAc-ol. These results showed the heterogeneous nature of the carbohydrate chains of BSM.

Animals↗
PubMed1986

Purified tyrosine kinases, the EGF receptor kinase and the src kinase, can catalyze the phosphorylation of the band 3 protein from human erythrocytes.

The band 3 glycoprotein from human erythrocytes was found to be phosphorylated on tyrosine residues by the purified EGF receptor kinase and the purified src kinase in vitro. Kinetic analysis revealed that Km of the band 3 protein phosphorylation by the EGF receptor kinase was 0.17 microM and 0.65 microM in the absence and presence of EGF (3 X 10(-7)M), respectively, and that in the case of the src kinase it was 0.4 microM. From these data the band 3 protein can be regarded as one of the best substrates common for the EGF receptor kinase and the src kinase in vitro.

Anion Exchange Protein 1, Erythrocyte↗
PubMed1986

Immune complex containing herpesvirus antigen in a patient with acute retinal necrosis.

A 21-year-old man with acute retinal necrosis showed a marked increase in the convalescent titer to herpes simplex type 1 virus, especially in the aqueous humor obtained by anterior chamber paracentesis. Using an enzyme-linked immunosorbent assay, we tried to detect the herpesvirus antigen in the circulating immune complex obtained from this patient. The immune complex contained an antigen or antigens that reacted with antiherpes simplex type 1 antibody.

Acute Disease↗
PubMed1986

Congenital aplasia of the extensor muscles of the fingers and thumb associated with generalized polyneuropathy: an autosomal recessive trait.

Three sibs born to normal but consanguinous parents had flexion deformities of the thumb and fingers on one hand and sensory deficit in the other hand. Extensor muscles were absent or vestigial in all of them. Polyneuropathic electrophysiological findings were detected in 4 limbs. This is an apparently autosomal recessive trait previously unreported.

Contracture↗
PubMed1986

Responses of isolated canine and simian basilar arteries to thiopentone by a newly designed pharmacological method for measuring vascular responsiveness.

The stainless steel cannula inserting method was modified for application to observe vascular responses to thiopentone in the isolated basilar arteries of the dog and monkey. In the dog, thiopentone (0.01-3 mg) induced a monophasic vasoconstriction in a dose-dependent manner. On the other hand, in the monkey, thiopentone (0.01-3 mg) showed a biphasic vascular response, i.e., an initial vasoconstriction followed by a vasodilatation in a dose-dependent manner. Thiopentone usually produced much more potent vasoconstriction in the dog than that in the monkey, while potassium chloride made little difference of vasoconstriction between the dog and monkey basilar arteries. These findings suggest that thiopentone exerts a direct constrictive effect on cerebral vessels, the actions of which decrease the total cerebral blood volume and the brain bulk, allowing a reduction in intracranial pressure.

Animals↗