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Biomedical subjects

T Tsuda

Publications and source records attributed to T Tsuda.

At least 685 records · Page 38Linked to original sources
PubMed1980

Prostaglandin analogues possessing antinidatory effects. 1. Modification of the omega chain.

Novel prostaglandin analogues modified in the omega chain were prepared by the reaction of the vinyl aldehydes 1a--e with a variety of organometallic reagents as a key step of the syntheses. Compared with the natural prostaglandin F2 alpha in antinidatory effect, the analogues 4, 7, and 10 were 40 times more potent and the analogue 11 was 50--100 times more potent in the rat.

Abortifacient Agents, Nonsteroidal↗
PubMed1980

Prostaglandin analogues possessing antinidatory effects. 2. Modification of the alpha chain.

Additional double bonds were introduced into the alpha chain in 16-phenoxy-, 16-(3-chlorophenoxy)-, 16-[3-(tri-fluoromethyl)phenoxy]-, and 16-(4-chlorophenoxy)-17,18,19,20-tetranorprostaglandins which have antinidatory effects. Of these analogues, the delta 3-cis-delta 5 analogues 23b is 1200 times more potent than prostaglandin F2 alpha in antinidatory effect in the rat and more potent than any other known prostaglandin analogues.

Abortifacient Agents, Nonsteroidal↗
PubMed1980

Clinical, hematological and pathological responses in severely heat-stressed steers with special reference to the threshold value for survival.

To find out a critical point of physiological responses of steers which would finally lead to death due to heat stress, four Holstein steers weighing about 300 kg were housed in an artificial climatic room and exposed to each of the following room temperature and relative humidity: 35 degrees C and 70 per cent, 36 degrees C and 80 per cent, 38 degrees C and 70 per cent, and 42 degrees C and 60 per cent. Sequential clinical and hematological examinations were carried out during thermal loads on the steers, and pathological examinations after their death or slaughter. All the steers manifested panting, rise of rectal temperature, reduction or disappearance of peristalsis, hypersalivation, dysfunction of the skin reflex, and remarkable decrease in white blood cell count and pressure of CO2 (Pco2) value of jugular blood. At the end of heat stress, an animal would be survived if it meet the following conditions: (1) rectal temperature was below 42.7 degrees C, (2) the respiration rate did not decrease to one half (about 100/minute) of the maximum rate during the exposure period, (3) peristalsis and skin reflex disappeared almost completely, (4) the white blood cell count did not decrease to less than 50 per cent of the normal level, and (5) the Pco2 value of venous blood was maintained at a level of more than 15 mmHg. Cloudy discoloration with a boiled-meat appearance was noticed in the skeletal muscle of the hind part of the body in two dead cases. No significant changes were detected in any other steer slaughtered several days after release from the thermal stress.

Animals↗
PubMed1979

Chronologic changes of activities of naphthol AS-D acetate esterase and other nonspecific esterases in the mononuclear phagocytes of tuberculous lesions.

Nonspecific esterases of mononuclear phagocytes (MNs) were studied histochemically in the developing and healing tuberculous lesions produced in rabbit skin by bacille Calmette Guérin (BCG). Nonspecific esterases were assayed with the following substrates: naphthol AS-D acetate (AS-D), naphthol AS-D chloroacetate (AS-D Chl), naphthol AS acetate (AS) and alpha-naphthyl acetate (alpha-N), beta-Galactosidase, a lysosomal enzyme of MNs, was also assayed as a marker of MN activation. The number of MNs hydrolyzing AS-D Chl, AS, and alpha-N increased for 2 to 4 weeks after infection. These chronologic changes were similar to that of beta-galactosidase. In contrast, MNs hydrolyzing AS-D appeared predominantly in the healing lesions five to six weeks after infection. These MNs had the morphologic features of balloon-like cells. They contained few lysosomes and gathered in clumps far from the caseous center. The activity of the AS-D esterase was almost completely inhibited by various trypsin inhibitors, but not by the serine esterase inhibitor of phenylmethylsulfonyl-fluoride. These results suggest that the AS-D esterase is a trypsin-like esterase which participates in the healing of tuberculous lesions.

Animals↗