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Biomedical subjects

T Takeda

Publications and source records attributed to T Takeda.

At least 1,333 records · Page 74Linked to original sources
PubMed1979

Hepatic bruits in malignant liver tumors.

There have been few reports concerning hepatic bruits in malignant liver tumors, especially in those other than hepatocellular carcinoma. Lately we noticed hepatic bruits in several cases of malignant liver tumors. The murmurs were confirmed by sound recordings. In cases of hepatocellular carcinoma the murmurs were continuous or continuous with late systolic accentuation. In a case of cholangiocarcinoma of the liver the murmur was continuous with late systolic accentuation and in a case of metastatic liver carcinoma it was systolic. These murmurs were considered to be caused by various mechanisms and some of them are discussed in this paper. Hepatic bruits would be a useful aid in diagnosing hepatic tumors.

Adenoma, Bile Duct↗
PubMed1979

Bilateral Meniere's disease.

A survey of 265 Japanese patients with Meniere's disease revealed bilateral involvement in approximately 29% of all these patients. Somatic and psychiatric aspects of bilateral Meniere's disease were as follows. (1) The duration of the disease in cases of bilateral involvement was significantly longer than cases of unilateral involvement. (2) An abnormal general condition, a more extensive degree of hearing loss and neurotic type were frequently diagnosed in cases of bilateral involvement. Based on these results, it was concluded that psychiatric management and prevention of aggravation of deafness should be part of the management of treatment in bilateral Meniere's disease.

Female↗
PubMed1979

Syntheses of 1-beta-D-arabinofuranosyl-5-hydroxymethyl-N4-alkylcytosine.

Starting from uridine, 1-beta-D-arabinofluranosyl-5-hydroxymethyl-N4-alkylcytosines were prepared via 1-beta-D-arabinofuranosyluracil. During the course of this synthetic work, an interesting observation has been made that 5-acetoxy group of 1-(2,3,5-tri-O-acetyl-beta-D-arabinofuranosyl)-5-acetoxymethyluracil and its derivatives was easily displaced at room temperature with alkylamine in methanol, but not in chloroform, to give the corresponding 5-alkylaminomethyl derivatives.

Cytarabine↗
PubMed1978

Chemical composition in various compartments of inner ear fluid.

Sodium, potassium, chloride, glucose and total protein were determined in samples of scala vestibuli perilymph, scala tympani perilymph, CSF, cochlear endolymph and utricular endolymph from normal cats. Small but significant differences were evident in the concentrations of sodium and potassium between the scala vestibuli and scala tympani perilymph. It was also apparent that each compartment of endolymph has different values for sodium and potassium concentrations. Compared with the endolymph, the perilymph was found to contain a higher concentration of glucose and total protein. These findings are discussed from the view point of biological significance.

Cerebrospinal Fluid↗
PubMed1978

Changes in collagen cross-linking and lysyl oxidase by estrogen.

Dermal collagen solubility and lysyl oxidase activity of bones were measured in DDD mice of advancing age. Insoluble fractions of the dermal collagen increased more rapidly in females than in males after 5 weeks of age. Activity of the lysyl oxidase extracted from bones was higher in females than in males after 4 weeks of age. After sexual maturation, such sex differences were always observed in skin as well as in bone tissue. In other experimental animals, dermal collagen solubility was markedly decreased by estrogen treatment and lysyl oxidase was remarkably activated by estrogen in both skin and bone. Thus it is clear that estrogen stimulates the enzyme activity and accelerates the maturation of collagen and elastin in extracellular space.

Aging↗
PubMed1978

Gas exchange in the carp gills in normoxic and hypoxic conditions.

Respiratory exchange measurements in a teleost fish, Cyprinus carpio, in normoxic and hypoxic conditions are presented. Oxygen pressure in the dorsal aortic blood in normoxic carp was much lower than that in most of teleosts and elasmobranchs in similar conditions. The most evident physiological adjustment to the hypoxic condition was the increased ventilation due to an increased frequency of operation of the branchial pump. Increased perfusion at the gills played a small role in the physiological adjustments.

Animals↗
PubMed1978

Effects of prostaglandin F2alpha on egg transport and in vivo egg recovery from the vaginas of rabbits.

The effects of prostaglandin F2alpha (PGF2alpha) on egg transport and vaginal egg recovery were examined in rabbits. Little disturbance of egg transport was induced by an injection of 2 or 5 mg/kg of PGF2alpha 12 hours after mating. A remarkable disturbance of egg transport was seen when 5 mg/kg were injected 22 hours after mating. The administration of PGF2alpha24 hours after mating led to maximal vaginal egg recovery: 48.4% and 54.8% of eggs were recovered by 51 hours after treatment, and implantation rates were 3.2% and 6.5% after treatment with 2 and 5 mg/kg, respectively. The earliest eggs were recovered vaginally 3 hours after administration of PGF2alpha at 24, 36, 48, or 96 hours after mating. The recovery of slightly bloody washing fluids at the first and second vaginal washings in animals treated 24 or 36 hours after mating appears to indicate that severe uterine contractions were induced by PGF2alpha.

Animals↗
PubMed1978

Detection of cholera enterotoxin activity in suckling hamsters.

For detection of cholera enterotoxin activity, suckling hamster, mouse, and rat models were compared. It was found that not only suckling mice but also suckling rats and hamsters were sensitive to cholera enterotoxin. Among these models, suckling hamsters were the most sensitive and gave positive results with about 1/100 the cholera toxin seen in suckling mice and rats.

Administration, Oral↗
PubMed1978

Elevation of the salvage synthesis of ribonucleic acid in the rat liver during the induction of hepatoma with 3'-methyl-4-(dimethylamino)azobenzene.

Incorporation of uracil and orotic acid into the ribonucleic acid (RNA) fraction of rat liver during carcinogenesis induced with 3'-methyl-4-(dimethylamino)azobenzene was investigated. Uracil incorporation was found to be gradually elevated during the early stage (about 2 weeks) of the carcinogenesis, although not in the normal rat liver homogenates contacted with the carcinogen for a short hours, and the elevated uptake was maintained until tumor induction. On the other hand, orotic acid incorporation reverted to the original level after a temporary increase during the early stage. In a good agreement with the increased uracil incorporation, activities of both uridine phosphorylase and uridine kinase involved in the salvage pathway of RNA synthesis also increased during the early stage, and their activities in the liver were maintained at elevated levels after discontinuance of the carcinogen feeding. The activity of uridine monophosphate (UMP) pyrophosphorylase, converting uracil to UMP, was not detected during the early stage. Significance of the activation of the salvage pathway of RNA synthesis during the early stage of an axo dye-induced carcinogenesis were discussed.

Animals↗