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T Takeda

Publications and source records attributed to T Takeda.

At least 1,189 records · Page 66Linked to original sources
PubMed1985

[Quantitative analysis of myocardial perfusion by digital subtraction angiography].

Digital subtraction angiography (DSA) has been adopted to detect ischemic myocardial areas and to quantitatively evaluate the degrees of myocardial perfusion abnormalities. Subtraction for selective coronary arteriography was performed sequentially between mask and enhanced images in the same cardiac phases by means of ECG signals. We obtained three distinct perfusion phases which we termed the arterial, capillary, and venous phases. Densitometry of the circumferential cardiac wall was performed on these sequential images. The results were compared with 201Tl myocardial scintigrams and cine angiograms. In the arterial phase, the abnormalities of the coronary artery, such as stenosis, obstruction and collaterals were represented. In the capillary phase, contrast materials served as markers of myocardial perfusion and delineated infarctions as areas of low contrast enhancement compared to the normally perfused myocardium. In the venous phase, the infarcted areas were represented as areas with greater relative contrast enhancement than that of the normal myocardium. Circumferential analysis of perfusion could provide more detailed information about myocardial ischemic areas and the degrees of ischemia. Although we used invasive selective coronary arteriography, DSA techniques have numerous merits such as excellent temporal resolution, spatial resolution, and good contrast resolution, over conventional methods. Quantitative DSA methodology which we developed provided not only anatomical information about the main coronary arteries but new information about abnormalities of peripheral myocardial perfusion.

Angiography↗
PubMed1985

[Regional myocardial perfusion abnormality detected by digital subtraction angiography in a case of patent ductus arteriosus with coronary arterial fistulae].

A 19-year-old woman with patent ductus arteriosus and increasingly severe chest pain received various examinations including exercise stress radionuclide test, which revealed hypokinesis and decreased myocardial perfusion in the apex and left ventricular dilatation. Conventional selective coronary arteriography and newly-developed ECG synchronized digital subtraction angiography (DSA) were performed to identify the genesis of her myocardial ischemia. Selective coronary arteriography revealed congenital coronary arterial fistulae in the right and left coronary arteries. The largest fistula was observed around the obtuse marginal artery terminating in the left ventricle. Although stenosis of the left circumflex and left anterior descending arteries (LAD) were not observed, the LAD appeared to be hypoplastic. Hypoplasia of the LAD and the steal phenomenon by arterial fistula could have been responsible for the myocardial ischemia in the apex, but this method did not clearly reveal the area and the degree of myocardial ischemia in the apex. Sequentially subtracted images during the arterial and capillary phases were obtained by utilizing ECG-synchronized DSA for selective coronary arteriography. For these images, densitometric analysis was adapted to the myocardial region, i.e. circumferential densitometry using 21 segments around the left ventricular wall. Decreased myocardial perfusion was clearly demonstrated in the apex in capillary phase images. Moreover, circumferential analysis provided detailed information about the area and the degree of impaired peripheral circulation in the myocardium. This analysis by DSA may prove useful for evaluating myocardial perfusion abnormalities.

Adult↗
PubMed1985

Morphologic demonstration of cytoplasmic ASSAM-related antigenic substance (CASSAM) by an immunoperoxidase technique.

Murine senile amyloid protein identified in the senescence-accelerated mouse (SAM) was called ASSAM, and the ASSAM-related antigenic substance was detected in the cytoplasm of hepatocytes, columnar epithelia of the small intestine, and epithelia of the proximal convoluted tubules of the kidney, with the use of an immunoperoxidase method. This substance, called CASSAM (cytoplasmic ASSAM-related antigenic substance), did not stain positively with Congo red nor fibril structure, as determined under an electron microscope. As the ASSAM (senile amyloid) deposition increased with advancing age, CASSAM observed in hepatocytes and columnar epithelia decreased both in SAM-P and SAM-R strains. In the liver of the SAM-P strain in particular, the incidence and intensity in deposition of ASSAM increased rapidly from 5 months of age; on the other hand, CASSAM observed in the hepatocytes decreased rapidly at about the same time. Cycloheximide-treated animals showed a significantly low concentration of SASSAM (serum ASSAM-related antigenic substance) and also a low incidence and intensity of CASSAM observed in the cytoplasm of the hepatocytes and epithelia of the small intestine. In colchicine-treated animals, SASSAM concentration was slightly lower, and the severity of CASSAM observed in the cytoplasm was slightly higher, in the liver and kidney, as compared with control values. CASSAM is assumed to be synthesized in the cytoplasm of the cell and to be secreted alone or in the lipoprotein form into the serum. This CASSAM or lipoprotein including CASSAM is perhaps a constituent of SASSAM (CASSAM is assumed to include apoSASSAM) and the hepatocytes and intestinal mucosal epithelia are possible production sites of apoSASSAM.

Aging↗
PubMed1985

[A clinical observation of genitourinary tract tuberculosis during the last decade].

Altogether, 92 patients were diagnosed as having genitourinary tuberculosis, and were treated at our clinic from 1972 to 1981. These patients form the basis for our statistical study. The incidence of genitourinary tuberculosis among our new outpatients showed a tendency to decrease and was less than 0.4% during the last five years. The mean age of the genitourinary tuberculosis patients was 42.8, rather higher than ten years ago. Of these, 41% had a history of tuberculosis and 54% chiefly complained of bladder-related symptoms. Tubercle bacilli were detected in 87% of the patients. About 45% of the patients with urinary tuberculosis underwent nephrectomy, which was indicated principally in cases of non-functioning kidneys and severe hydronephrosis. A combination of PAS, INH, and RFP was used most often and was administered in 58 cases. Used second most often was a combination of SM, PAS, and INH (administered in 46 cases).

Adolescent↗
PubMed1985

[Relationship between endoscopic features and prognosis of pm-gastric cancer--with special reference to the depressive type of pm-cancer].

In this report, operated advanced gastric cancer was analysed based on 96 cases of carcinoma of the proper muscle layer (pm-cancer) experienced between 1961 and 1982 at the Third Department of Internal Medicine, Tohoku University School of Medicine, and its associated hospital. Patterns of macroscopic findings in pm-cancer were classified into three types: (1) early type, (2) early-like cancer type, and (3) Borrmann's variety type. The degree of lymph node metastasis ascended in types (1), (2) and (3) in that order, and the five-year survival rate descended in the same order.

Female↗
PubMed1985

[Effect of cis-platinum in neuroblastoma].

We treated six children with neuroblastomas. They were all refractory to conventional chemotherapy or at an advanced stage when diagnosed. Patients were four males and two females aged 1 to 7 years old, with a mean age of 3.7 years. Total cis-DDP dose ranged from 60 mg/m2 to 720 mg/m2, with a median dose of 240 mg/m2, and a mean dose of 260 mg/m2. Of the six children, two were PR, three were PD, and one was NC. Of three non-responses, two cases were clinically improved. Two cases had renal dysfunction but this improved within 3 weeks. It is said that cis-DDP induces irreversible renal damage, especially tubular necrosis. Our two cases had progressively decreased creatinine clearance, though values of BUN and creatinine were normal. Bone marrow suppression was mild, so there was no need to discontinue or modify the cis-DDP chemotherapy schedules. Two hypo-magnesemia were found, both cases being asymptomatic. Transient liver dysfunction occurred in one child, and nausea and vomiting were observed in almost all cases.

Bone Marrow↗
PubMed1985

[Acute spontaneous subdural hematoma associated with multiple aneurysms--a case report].

A case of acute spontaneous subdural hematoma associated with three aneurysms is reported. On March 12, 1984, a 47-year-old woman experienced the sudden onset of severe headache over the bilateral frontal region and vomiting. Three hours later, she was transferred to our hospital by ambulance car because of continuous headache and vomiting. She had no history of head trauma. She had been medicated hypertension for five years. On admission she suffered from headache and nausea. But there was no clinical sign in physical and neurological examinations. The meningeal irritation was not present, but lumbar puncture showed slightly pinky CSF with normal pressure. A plain computed tomographic scan showed a thin high density mass in the left temporal extra-axial region and the slight deviation of the midline structures to the right. Left carotid arteriogram showed an avascular region over the left cerebral convexity, an aneurysm of the left A2-A3 junction and a questionable aneurysm of the bifurcation of left middle cerebral artery. Right carotid arteriogram showed an aneurysm of the bifurcation of right middle cerebral artery. We diagnosed this case as an acute subdural hematoma by CT scan and arteriogram. We were perplexed preoperatively whether this bleeding was spontaneous or secondary to the rupture of aneurysm, and we could not deny the possibility of a ruptured aneurysm. On March 15, 1984, three days after onset, operation was performed. At operation, a small subdural hematoma was removed, and the underlying cortex was normal.(ABSTRACT TRUNCATED AT 250 WORDS)

Acute Disease↗
PubMed1985

Advanced neuroblastoma and disseminated intravascular coagulation: report of six cases.

We have experienced 30 patients with neuroblastoma since 1975. Disseminated intravascular coagulation (DIC) developed in six of these patients. They were all in stage IV, namely disseminated neuroblastoma. These six cases with DIC proved that some advanced neuroblastomas have the potential to cause coagulopathy in the process of the disease. The plasma concentration of heparin was measured in some patients who were treated with heparin. The data revealed that the conventionally used intravenous heparin dose is not appropriate in the case of DIC. Effective treatment requires monitoring of the plasma concentration of heparin.

Abdominal Neoplasms↗
PubMed1985

[Gastric cancer and serum zinc content].

Changes in the serum zinc content of patients with gastric cancer were investigated in connection with the size of the primary lesion, the depth of invasion into the gastric wall, the presence or absence of liver metastasis and the histological types. The serum zinc content of the patients decreased along with the progress of the cancer. The changes in serum zinc were closely related to the extent and severity of the disease, but were independent of the presence of liver metastasis and of the histological types in patients with gastric cancer. As a cause of decreasing serum zinc in cancer patients, a decrease of serum albumin was emphasized. The relationship between the decrease of serum zinc and accumulation of zinc in the tumor tissue in patients with gastric cancer could not be elucidated.

Animals↗
PubMed1984

Mass screening for neuroblastoma in infants in Japan. Interim report of a mass screening study group.

A mass screening system for the early detection by means of a vanillylmandelic acid test of neuroblastoma in 6-month-old infants in Japan has been developed in eight districts. 16 of the 281 939 infants screened by this test had neuroblastoma, equivalent to a very high incidence of 1 in 17 621. 15 of the 16 children with neuroblastoma are alive; the other child died 1 month after surgery. This mass screening system for neuroblastoma used in infancy can help to improve prognosis in infants with this malignant disorder.

Adrenal Gland Neoplasms↗
PubMed1984

Hypereosinophilic syndrome in acute lymphoblastic leukemia with a chromosome translocation [t(5q;14q)].

We report a case of hypereosinophilic syndrome associated with acute lymphoblastic leukemia (L1 type, FAB classification) which showed an abnormal karyotype. An 8-year-old boy was admitted to our hospital with complaints of fever and cough that had persisted for 2 weeks. Peripheral blood examination revealed remarkable eosinophilia (120,000/mm3) and a few lymphoblasts. Bone marrow examination also revealed many mature eosinophils and 20% lymphoblasts that were PAS and peroxidase negative. A direct chromosome analysis of the bone marrow cells demonstrated that 12.5% of the spontaneously dividing cells had an abnormal karyotype of 46XY, t(5;14) (q31;q32). The chest radiogram showed interstitial pneumonia-like densities, and the ECG had the pattern of a right bundle branch block. The therapy consisted of prednisolone, high dose of methylprednisolone, cyclophosphamide, and vincristine. This treatment failed to reduce the eosinophil count. On the 4th day after admission, the patient developed severe dyspnea, complete A-V block, and died. At postmortem, dense infiltrations of eosinophils in various stages of maturation were noted in lungs and liver.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1984

Cataract and other ophthalmic lesions in senescence accelerated mouse (SAM). Morphology and incidence of senescence associated ophthalmic changes in mice.

In a murine model of accelerated senescence (SAM), grading score and incidence in cataract, periophthalmic lesions, opacity and ulcer of the cornea were determined in mice from 4 to 24 months of age. From 4 to 6 months of age, incidence and grading score of these four categories began to increase in both the accelerated senescence prone (SAM) and resistant series with normal aging, and these increases continued with aging. As compared with the resistant series, there was a higher incidence and grading score of the four categories and a higher rate of increase in the prone series. The prone 3 series in particular showed a much higher incidence and grading score on cataract, the rate being 27.5% and 70.6% at 12 and 16 months, respectively. Histologically, the cataract was classified into two types. In one, degeneration of lens fibers, disintegration of lens cortex, and at an advanced stage, liquefaction of the lens cortex and proliferation of the anterior lens epithelial cells occurred. In the other type, lens fibers lost their distinct shapes and a homogenous mass formed at the anterior and posterior superficial cortex. The anterior lens epithelial cells had shrunk. There was an opacity and ulcer of the cornea with keratitis and the corneal epithelium was lost in case of the latter. Periophthalmic lesions included catarrhal changes of the skin of the eyelids and face and blepharitis. There were no lesions specific to each of the prone and resistant series. Thus, SAM should prove to be a suitable murine model for investigation of age-related ophthalmic lesions, including cataract in humans.

Aging↗
PubMed1984

Age-related changes of serum apoprotein SASSAM, apoprotein A-I and low-density lipoprotein levels in senescence accelerated mouse (SAM).

Age-related changes of serum concentration of apo SASSAM, an apoprotein of high density lipoprotein (HDL) which cross-reacts with antiserum against murine senile amyloid fibril protein (ASSAM) were estimated in senescence accelerated mouse (SAM-P) and in senescence resistant series (SAM-R), as a control, using a single radial immunodiffusion technique. Serum concentrations of apo A-I, a major apoprotein of HDL, and low density lipoprotein (LDL) were also measured. In SAM-P (SAM-P/1 and SAM-P/2) with a high incidence of senile systemic amyloidosis, we observed age-associated decreases in serum apo SASSAM levels. The concentrations of apo SASSAM at 16 months of age were below 40% of the concentration at 2 months of age, regardless of the sex. In contrast with SAM-P, we observed no age-associated decrease of serum apo SASSAM levels in SAM-R (SAM-R/1 and SAM-R/2) with a low incidence of amyloidosis. Serum apo SASSAM concentration was higher in SAM-R/1 than in any other strain of mice observed. Serum apo A-I concentration was highly and significantly correlated with the serum concentration of apo SASSAM and decreased with advancing age in SAM-P but not in SAM-R. Age-related changes of LDL were not observed in any strain, but the concentration was lower in the females. In old SAM-P (16 months' old), the concentration of apo SASSAM decreased to one-third of that in the young SAM-P (4 months' old) and the serum concentrations of albumin and total protein did not decrease, compared with those in the young mice. All these findings taken together suggest that abnormality of metabolism in apo SASSAM, putative precursor of ASSAM, might occur in SAM-P.

Aging↗