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Biomedical subjects

T Takeda

Publications and source records attributed to T Takeda.

At least 1,207 records · Page 67Linked to original sources
PubMed1984

Responses of the nucleus of the optic tract neurons projecting to the nucleus reticularis tegmenti pontis upon optokinetic stimulation in the rabbit.

The activity of cells (n = 55) in the nucleus of the optic tract (NOT) in pigmented rabbits was recorded extracellularly. All cells were activated orthodromically from the optic chiasm (latency 2.3 +/- 0.4 ms, mean and S.D., n = 33). The mean conduction velocity of optic nerves to the NOT was 19.0 m/s, and the mean nuclear delay in the NOT was 0.9 ms. Stimulation to the nucleus reticularis tegmenti pontis (Nrtp) antidromically activated 37 cells (latency 1.0 +/- 0.3 ms) (Nrtp(+)cell) but did not antidromically activate the other 18 cells (Nrtp(-) cell). The response properties were studied by spike density histograms constructed during the application of moving visual stimuli (random dot patterns, 0.1-200 degrees/s). The optimal velocity was 5-50 degrees/s for the majority (74%, n = 29) of the total samples tested. Of 10 cells preferring high velocities (75-150 degrees/s), four times as many Nrtp(+) cells (n = 8) preferred high velocities as did Nrtp(-) cells. The optimal velocities of Nrtp(+) cells significantly correlated with the rostro-caudality of recording sites in the NOT, the more rostral cells preferring a slower velocity. Nrtp(+) cells preferred not only a horizontal (53%) but also a vertical or diagonal orientation in contrast to the majority (71%) of Nrtp(-) cells, which preferred a horizontal orientation. The receptive fields (mean size 28 degrees X 15 degrees) scattered horizontally corresponding to the visual streak of the retina.

Animals↗
PubMed1984

Collateralized projection of visual climbing fibers to the flocculus and nodulus of the rabbit.

Electrical stimulation of the rabbit cerebellar flocculus evoked responses in Purkinje cells of the nodulus by an axon reflex through collateralized climbing fibers (latency 4.2 ms). These responses interfered with those evoked by stimulation of the optic nerve in the manner of occlusion. Stimulation of the nodulus induced similar axon reflex responses in the flocculus. To identify the cells of origin of this collateralized climbing fiber projection, different fluorescent retrograde tracers, propidium iodide and 4',6-diamidino-2-phenylindole, were injected into the nodulus and flocculus. In the contralateral inferior olive, the majority (85%) of double-labeled cells were found in the dorsal cap and the rest (15%) in the ventrolateral outgrowth. These results lead to a conclusion that some inferior olive neurons convey common visual signals with collateralized axons to both the flocculus and the nodulus.

Animals↗
PubMed1984

Ph1-positive and Ph1-negative abnormal cell lines in a child with lymphoblastic lymphoma.

A 7-year-old Japanese boy with Ph1-positive-lymphoblastic lymphoma is described. The diagnosis was based on biopsied tonsils which were enlarged at the time of admission. On the eighth day after admission an enlarged mediastinal mass was detected on a chest X-ray film. The lymphoblasts which appeared in the peripheral blood and bone marrow proved to be T-cells. Chromosome studies on the bone marrow cells revealed two abnormal cell lines; one had a 7;11 translocation and the other a 7;11 translocation and a 9;22 translocation, forming the Ph1-chromosome. The latter line with the Ph1-chromosome was considered to have been derived from the former line without the Ph1. Our findings show that the Ph1-chromosome may be a secondary change in the course of karyotypic evolution.

Bone Marrow↗
PubMed1984

Renal histological studies in patients with Takayasu's arteritis. Report of 3 cases.

Clinical findings and structural alterations of the kidney in 3 patients with Takayasu's arteritis (TA) and associated glomerulonephritis are described. Clinical evidence of renal disease included persistent proteinuria and microscopic hematuria in all patients. Renal histology showed proliferative glomerulonephritis in 2 of the 3 patients. In 1 patient in whom sequential examination of the kidney was possible, glomerular changes had progressed in severity, in parallel with the expansion of arterial damage of TA. Prednisolone therapy induced a complete disappearance of systemic symptoms of TA and an improvement of proteinuria and hematuria. These findings suggest that TA, which quite possibly results from an immune response to disseminated antigen(s), may occasionally induced glomerulonephritis as a part of its histological expression.

Adult↗
PubMed1984

Functional significance of coronary collateral vessels during exercise evaluated by radionuclide angiocardiography: the importance of supplying arteries.

To investigate the function of coronary collateral vessels, especially from view point of supplying arteries, radionuclide angiocardiography was performed before and during a symptom-limited ergometer exercise in 54 patients with effort angina. In single vessel disease, during exercise, left ventricular ejection fraction (EF) (%) increased in the cases with coronary collateral vessels (supplied from patent arteries) (72 +/- 7----77 +/- 8, p less than 0.025), but decreased in those without (66 +/- 10----61 +/- 10, P less than 0.001). In multivessel disease, EF decreased during exercise even in those with collaterals (supplied from stenosed arteries) (67 +/- 10----59 +/- 8, p less than 0.001). It is concluded that angiographic appearance of the coronary arteries supplying collateral vessels is a major predictive factor of the function of coronary collateral vessels and of left ventricle during exercise.

Adult↗
PubMed1984

Testing of otolith function.

In order to investigate otolith function, horizontal eye displacement in total darkness during tilting laterally about body axis was examined in 23 normal subjects and 29 patients with vestibular lesions. The mean and standard deviation of this eye displacement in normal subjects were 18.9 + 6.1 degrees at 15 degrees of body-tilt. Thus, eye displacement below the lower tolerance limit of normal eye displacement at 15 degrees of body-tilt, that is, 8.8 degrees, was judged to be abnormal. Meanwhile, 12 cases or 41.4% of 29 patients with vestibular lesions showed abnormal eye displacement in this test. Especially in cases with positional vertigo and/or dizziness, the occurrence of abnormal results in this test (69%) was far higher compared with that of cases where vertigo and/or dizziness was not associated with postural changing (19%). Therefore, these abnormal results seem to be closely related to the disorder of otolith system.

Aged↗
PubMed1984

[Chemotherapy of gastric and rectal cancers incorporating non-radical irradiation during remission induction. 1].

For the remission induction therapy of advanced gastric and rectal cancer, 25 cases were treated by non-radical irradiation (total doses: 3000-6000 rad) combined with tegafur, which minimized the tumor mass. For the reduction of tumor mass, a modified method of FAMT was employed and for the maintenance therapy of long-term chemotherapy a modified method of FAMT, MFE, MF or tegarfur alone were performed. Prolongation in survival was obtained with this combination therapy: Of 25 cases, 11 cases survived longer than one year and 6 cases longer then two years. One case of survived rectal cancer obtained disease-free for about 8 years with this treatment. But the observation period was too short to calculate one-year and two-year survival rates of all cases. The indications for application of this combination therapy were as follows; (1) Locally operable cases with myocardial infarct, heart insufficiency, poor risk or refusal of operation, (2) Very aged patients, (3) Locally inoperable cases without clinical metastasis, and (4) Primary lesion of gastric cancer with small metastasis controllable by tegafur. It was concluded that over 3000 rad of irradiation combined with tegafur was necessary to obtain the sufficient radiation effect. As for side effects, loss of appetite , leukopenia and a few case of gastric bleeding by radiation were noted. From the result this treatment modality appears to be valuable in the management of gastric and rectal cancer.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1984

Synthesis of oligonucleotides containing the hypermodified base, alpha-putrescinylthymine.

Dodecathymidylic acids containing alpha-putrescinylthymidine, 5-methylamino-methyl-2'-deoxyuridine and 5-methoxymethyl-2'-deoxyuridine were prepared by the phosphotriester polymer support synthesis. The melting temperatures of the synthetic oligomers-polydeoxyadenylic acid complexes show that the secondary amino group at putrescinylthymidine decreases the thermal stability of complexes and the primary amino group at the putrescinyl residue increases the stability.

Base Sequence↗
PubMed1984

Propylthiouracil-induced diffuse interstitial pneumonitis.

Cough productive of sputum, exertional dyspnea, and hypoxemia developed in two patients with Graves' disease after six months (patient 1) or three weeks (patient 2) of treatment with propylthiouracil, 300 mg/day. Chest roentgenograms and transbronchial lung biopsy specimens revealed diffuse interstitial pneumonitis. Lymphocyte transformation by phytohemagglutinin was highly stimulated by propylthiouracil. Symptoms and signs improved after cessation of the drug therapy and administration of prednisolone acetate. These cases represent the first report of a complication of diffuse interstitial pneumonitis induced by propylthiouracil.

Aged↗
PubMed1984

Rebound phenomenon in glycerol test.

The glycerol effect for endolymphatic hydrops is well known for an improvement in pure tone threshold three hours after glycerol administration. However, long-term effects of glycerol, i.e., longer than three hours after administration, are unknown. In this study, audiometric tests were administered during 10 hours following glycerol administration in order to determine the long-term effects of glycerol in cases of Meniere's disease, sudden deafness, and normal subjects. The following results were obtained; 1) The long-term effects of glycerol in the pure tone threshold were observed only in cases of Meniere's disease and were classified into the following four types: "descending type", "descending and ascending type", "ascending type" and "unchanged type". 2) The long-term effects, including rebound phenomenon, on hearing ability did not appear in cases of sudden deafness and normal subjects. 3) About 50% of patients with Meniere's disease showed rebound phenomenon on hearing ability and it was considered to be specific for Meniere's disease.

Audiometry↗
PubMed1983

Isolation and characterization of senile amyloid--related antigenic substance (SASSAM) from mouse serum. Apo SASSAM is a low molecular weight apoprotein of high density lipoprotein.

Sera obtained from senescence-accelerated mouse (SAM) and normal mice contained a substance that reacted with antiserum raised against ASSAM, a novel senile amyloid fibril protein isolated from the liver of SAM. This physiological substance, termed "SASSAM" (serum ASSAM-related antigenic substance), migrated to the albumin/prealbumin region in immunoelectrophoresis and the precipitation line formed with anti-ASSAM antiserum was stained positively with both Amide Black 10 B and Oil Red O/Fat Red 7B solutions, thereby suggesting that SASSAM is an alpha lipoprotein. Using Sephadex G-200 gel chromatography, SASSAM was eluted as a high mol wt form of approximately 200,000 daltons. Fractionation of lipoprotein from normal mouse serum by preparative ultra-centrifugation disclosed that SASSAM was found mainly in high density lipoprotein, HDL (the density is between 1.063 and 1.21 g/cm3). The largest amount of SASSAM was found in the HDL2 fraction (the density is between 1.063 and 1.125) and in this fraction SAA was not detected. Furthermore, ASSAM immunoreactivity appeared in the low mol wt proteins (below 10,000 daltons) of apo HDL separated in the buffer containing 8 M urea through Sephadex G-200. In 8 M urea sodium dodecyl sulfate (SDS)-polyacrylamide gel electrophoresis (PAGE), the major components of apolipoproteins in this position, possibly corresponding to apo C proteins, have the same molecular weight, 5,200 daltons, as ASSAM and this component was labeled by anti-ASSAM antiserum after transfer to nitrocellulose paper.

Aging↗