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Biomedical subjects

T Sugai

Publications and source records attributed to T Sugai.

At least 145 records · Page 8Linked to original sources
PubMed1984

The sequence and correlation of the changes in several parameters of energy metabolism induced by ischemic insult in heart muscle.

Samples of myocardium with varying degrees of ischemia were obtained from subendo- and subepicardium of nonischemic, ischemic border and center zones of canine left ventricles to assess the sequence of rapid alterations of several parameters of energy metabolism induced by myocardial ischemia. Ischemia was induced by occluding the left anterior descending coronary artery. The contents of creatine phosphate (CP) and ATP decreased significantly. There was a significant accumulation of lactate. The redox potential (Eh) and phosphorylation potential (l') also decreased sharply, but only a slight decrease in energy charge (E.C.) was noted. A close correlation was found between ATP and total adenine nucleotide (r = 0.99). There were various degrees of linear correlation between other parameters, except for ATP (and total adenine nucleotide) and Pi, and CP and l', which were uncorrelated. The sequence of rapid alterations in the parameters of energy metabolism induced by ischemia was: (1) l' and CP, (2) Pi, ATP and Eh, and finally (3) lactate and E.C. A significant increase of the heart rate and a decline of the mean blood pressure and left ventricular pressure (LVP) were also observed in association with a slight change in the maximum rate of rise of the left ventricular pressure (dP/dtmax).

Adenine Nucleotides↗
PubMed1984

Pharmacological profile of a new beta-adrenoceptor blocker, 4-[3-(tert-butylamino)-2-hydroxypropoxy]-N-methylisocarbostyril hydrochloride (N-696).

To characterize the pharmacological profile of a new beta-adrenoceptor blocker, 4-[3-(tert-butylamino)-2-hydroxypropoxy]-N-methylisocarbostyril hydrochloride (N-696), experiments were performed in the isolated atria and trachea of the guinea pig, in the pithed rat, in the anesthetized rabbit, in anesthetized dogs and in anesthetized open-chest dogs. Antiarrhythmic action was assessed in conscious as well as in anesthetized dogs. Although N-696 was a non-selective beta-blocker 15-20 times less potent than propranolol under in vitro conditions, it was as effective a blocker as propranolol under in vivo conditions. N-696 produced a fall of the blood pressure in the pithed rat and attenuated the blood pressure rise produced by stimulation of the preganglionic sympathetic nerve. In the anesthetized rabbits, it produced a hypotensive effect associated with an increased discharge of the renal nerve. In anesthetized dogs it produced a hypotensive effect and a decrease in the myocardial blood flow. However, the decrease in the myocardial blood flow was smaller than that produced by propranolol. All these findings indicate that N-696 has a direct vasodilatory effect besides its beta-blocking action. As a beta-blocker N-696 was unique in that it produced a potent antiarrhythmic effect in two-stage coronary ligation arrhythmia.

Adrenergic alpha-Antagonists↗
PubMed1983

Mandibular traction for relieving respiratory distress in the Pierre Robin Anomaly. A case report.

A case of Pierre Robin Anomaly with severe, prolonged respiratory distress and feeding difficulties is presented. The respiratory distress is adequately relieved by mandibular forward traction. The procedure employing a mandibular suspension and elastic traction system is described. Feeding under the traction was successful, providing more effective self-control of the tongue. The authors recommend the mandibular traction device described here as a very simple life-saving approach to the problems in the Pierre Robin Anomaly.

Airway Obstruction↗
PubMed1983

Arterial pressure-urinary output relationship in DOCA-saline hypertensive rats.

To know the role played by the kidney in the genesis of deoxycorticosterone acetate (DOCA)-saline hypertension, the arterial pressure-urinary output (AP-UO) relationship was compared in unanesthetized, unrestrained uninephrectomized (1-K) control and normal Wistar-Imamichi (W-I) rats according to the method of Norman et al. [Am. J. Physiol. 234 (Regulatory Integrative Comp. Physiol. 3): R98-R103, 1973]. The gradient of AP-UO relationship was slightly decreased in 1-K control rats compared with that in W-I rats. However, the AP-UO relationship of DOCA-saline hypertensive rats underwent only a parallel shift to higher blood pressure ranges compared with that of 1-K control rats. There was no significant change in the urinary volume, urinary sodium excretion, and urinary osmolarity. Furthermore, the AP-UO relationship was shifted back to the lower pressure range under the influence of hydralazine, a preferential renal arteriolar dilator, suggesting that constriction of the renal artery caused the rise of the arterial pressure in DOCA-saline hypertensive rats.

Animals↗
PubMed1983

[Effects of several beta-blockers and penfluzide, a thiazide diuretic, on the blood pressure, urinary water output and excretion of Na and K in DOCA-saline-induced hypertension in rats].

Effects of beta-blockers on the blood pressure (BP), urinary output (V) and excretion of Na% (UNaV) and K+ (UKV) were studied in DOCA-saline hypertensive rats in comparison with those of a thiazide diuretic drug, penfluzide. Pindolol produced a hypotension at all infusion rates of Ringer's solution used and a decrease in V with a retention of Na+ and K+ at a low infusion rate. There was a parallel shift of Guyton's renal function curve back to the lower pressure ranges. Similar effects were observed with labetalol. Propranolol induced an increase in UKV at all infusion rates and had a diuretic action at a high infusion rate without producing a significant fall of BP. UKV tended to be increased after atenolol, with essentially no change in other parameters. A new beta-blocker with alpha-blocking action, K-351, produced a hypotension at intermediate and high infusion rates and an increase in UNaV (low infusion rate) and UKV (low and high rates). UKV tended to be increased with another new beta-blocker, N-696, with a fall of BP at high infusion rate. Penfluzide produced a significant decrease in BP at intermediate and high infusion rates and an increase in UKV at all infusion rates.

Adrenergic beta-Antagonists↗
PubMed1982

[Clinical evaluation of cefmetazole in the dermatologic field].

The therapeutic efficacy and safety of cefmetazole, a cephamycin-derived antibiotic in an injectable form were evaluated in patients with pyogenic infection in the dermatological field. Especially, it was found to be extremely effective for the skin diseases due to staphylococci or streptococci. The results obtained were the following; marked improvement in 18 cases and moderate improvement in 34 cases out of 61 cases, attaining efficacy of 86.7%. Side effects were noted as the rise of GOT and GPT in 3 cases, which were normalized by ceasing its further administration. The MIC of cefmetazole against Staphylococcus aureus isolated out of foci was 0.39-6.25 microgram/ml, while those of CEZ, CXM and ABPC used as the controls exceeded 50 microgram/ml in some cases. It is considered thus, that cefmetazole, is superior to these other antibiotics also in terms of MIC.

Adolescent↗
PubMed1979

Age distribution of the incidence of contact sensitivity to standard allergens.

The incidence of contact sensitivity to standard allergens present in the daily environment, such as chromium ion, cobalt, nickel and formaldehyde, is found to decrease in the fourth decade. It strongly suggests the presence of some immunoregulation in human beings, because sensitivity to these allergens should be equal in any decade.

Adolescent↗
PubMed1977

Pigmented cosmetic dermatitis and coal tar dyes.

Patch tests and photopatch tests with various cosmetics, coal tar dyes, perfumes, lanolin preparations and parabens-mix were performed in 53 patients with pigmented cosmetic dermatitis similar in clinical appearance to Riehl's melanosis. The results showed that coal tar dyes, particularly brilliant lake red R, were closely related to the cause of the disease. In patch testing and photopatch testing with coal tar dyes, the incidence of positive responses to the brilliant lake red R was found to be significantly higher than that to the other coal tar colors (22/38 = 57.9%). The relevance of ultraviolet light to the disease was found to be much less than the ratio expected (14/47 = 29.8%). A high incidence of positive responses to fragrances was also found, but it is considered to play a secondary role in the etiology of the disease.

Coal Tar↗