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T Shigematsu

Publications and source records attributed to T Shigematsu.

At least 145 records · Page 8Linked to original sources
PubMed1989

[A statistical study of autopsies performed on cases of oral cancer: with reference to distant metastasis in tongue cancer].

1. A statistical survey of oral-cancer (tongue, maxilla, and mandible) patients on which autopsies were performed by the 2nd. Department of Pathology of Tokyo Dental College from 1964 to 1987 was carried out. Of a total of 18 autopsies in cases in which death resulted from tongue carcinoma, 11 subjects were male and 7 female. Average age was 63.4 years. This cancer occurred most frequently in individuals in the age group of 60 to 69 years. The lung was the most common (50%) site of distant organic metastasis; the next most common sites were the liver, the thyroid gland, and the diaphragm (11.1% each). Submandibular and cervical lymph nodes were the most common sites of lymphatic metastasis in cases of tongue cancer. These data were similar to those in previous reports. 2. An autopsy on a 57-year-old man who died of tongue cancer revealed a number of distant metastases in both organs and lymph nodes were reported. 3. The report includes a review of literature on distant metastasis in cases of tongue cancer.

Aged↗
PubMed1989

[A trial of suppressing secondary hyperparathyroidism by oral high dose therapy of 1, 25-dihydroxyvitamin D3].

We reported a successful treatment of secondary hyperparathyroidism by intermittent oral administration of high dose of 1, 25 dihydroxycholecalciferol [1.25-(OH)2D3] in three patients on maintenance hemodialysis. Dialysis durations were 4 months in case 1, 6.5 years in case 2 and 12.5 years in case 3. The levels of c-PTH ranged from 4.7 ng/ml to 94.2 ng/ml. 1, 25-(OH)2D3 in dosages up to 8.0 micrograms was given once a week just after hemodialysis. Before the administration and after 48 hours, serum Ca, serum Pi, serum Mg, c-PTH and highly sensitive PTH were assayed. There was a significant correlation between max. plasma concentration of 1, 25-(OH)2D and logarithm of the dose in all patients. The max. plasma level of 1, 25-(OH)2D reached 25-(OH)2D reached to 200 pg/ml at 4 hours after the oral administration of 8.0 micrograms. Their thresholds of 1, 25-(OH)2D level which could decrease the PTH levels were elevated proportionally to their dialysis durations. Case 1 required 4.0 micrograms to suppress secondary hyperparathyroidism, whereas, case 2 and 3 did 8.0 micrograms of 1, 25-(OH)2D3. Severe hypercalcemia was not observed during a high dose treatment. In conclusion, we have succeeded in treating refractory secondary hyperparathyroidism by intermittent oral administration of high dose 1, 25-(OH)3D3. This therapy is recommended to start in the earlier stage of a long-term dialysis in order to prevent severe secondary hyperparathyroidism and bone disease.

Administration, Oral↗
PubMed1988

In vitro study of the cross-sensitivity of hair dye using hapten-specific lymphocytes.

Paraphenylenediamine (pPDA), which is used frequently in hair dyes, has a high sensitization potential and is also well-known to cross-react with chemicals of similar structure. pPDA-specific lymphocytes from sensitized inbred guinea pigs were prepared and the cross-reaction of pPDA was examined using cultured epidermal cells as the target. The cytolytic effect was observed to be highest with pPDA, followed by paraaminophenol, orthophenylenediamine, and metaphenylenediamine. Resorcinol and the control produced no cytolytic reaction. These results showed a good correlation between in vitro and in vivo tests. The recognizing ability of hapten-specific lymphocytes is suggested to vary according to the position of the functional group and its type.

Animals↗
PubMed1986

Miscibility of phosphatidylcholine binary mixtures in unilamellar vesicles: phase equilibria.

Miscibility among phospholipids with different lipid chain-lengths or with different head groups has attracted a number of research efforts because of its significance in biological membrane structure and function. The general consensus about the miscibility of phosphatidylcholines with varying lipid chain-lengths appears to be that binary mixtures of phospholipids with a difference of two carbon atoms in the lipid chain mix well at the main phase transition. Miscibility between phosphatidylcholines with differences of four carbon atoms appears to be inconclusive. Previous reports on the phase transition of binary phospholipid mixtures are concerned mainly with multilamellar vesicles and are mostly limited to the main transition. In the present study, unilamellar vesicles were used and miscibility in binary systems between dimyristoyl-, dipalmitoyl- and distearoyl-phosphatidylcholines at pretransition as well as main transition temperatures was evaluated by constructing phase diagrams. Two methods were used to monitor the phase transitions: differential scanning microcalorimetry and optical absorbance methods. The optical method has the advantage that unilamellar vesicles of dilute phospholipid concentrations can be used. The liquidus and solidus phase boundaries were determined by the onset temperature of heating and cooling scans, respectively, because the completion temperature of a phase transition has no meaning in binary solutions. Dimyristoyl- and distearoyl-phosphatidylcholines, where the difference in the lipid chain-length is four carbon atoms, mixed well even at pretransition temperature.

Kinetics↗
PubMed1986

Kimura's disease and its relation to angiolymphoid hyperplasia with eosinophilia: report of three cases and review of the literature.

Kimura's disease, eosinophilic granuloma of soft tissues, is a chronic inflammatory condition and appears as subcutaneous tumor-like nodules in the head and neck regions. Histopathologically, it is characterized by the presence of lymphoid follicles, marked infiltration of eosinophils, fibrosis and vascular proliferation. This disease occurring in the orofacial region is relatively rare, only 14 cases having been previously reported. We describe 3 additional cases of Kimura's disease and discuss these in relation to angiolymphoid hyperplasia with eosinophilia.

Adolescent↗
PubMed1986

Human parathyroid hormone inhibits renal 24-hydroxylase activity of 25-hydroxyvitamin D3 by a mechanism involving adenosine 3',5'-monophosphate in rats.

The in vivo effect of PTH on renal 24-hydroxylase activity of 25-hydroxyvitamin D3 (25OHD3) was examined in vitamin D-deficient thyroparathyroidectomized rats by a recently developed sensitive in vitro assay of 25OHD3-hydroxylases using rat kidney homogenates and by an in vivo assay measuring the accumulation of tritiated metabolites in plasma 5 h after injection of 25OH[3H]D3. Infusion for 20 h of either human PTH-(1-34) (except at 800 pmol/h) or cAMP did not significantly change the plasma levels of calcium and phosphorus compared with those in thyroparathyroidectomized rats given 125 ng 1,25-dihydroxyvitamin D3 to induce renal 24-hydroxylase activity. On the other hand, human PTH-(1-34) markedly inhibited renal 24-hydroxylase activity and stimulated 1-hydroxylase activity. The effective concentration of human PTH-(1-34) was much lower for inhibiting 24-hydroxylase than for stimulating 1-hydroxylase activity. Infusion of less than 100 nmol/h cAMP similarly inhibited 24-hydroxylase activity without enhancing 1-hydroxylase activity. Either theophylline (1.0 mumol/h) or a submaximal dose (25 pmol/h) of human PTH-(1-34) alone inhibited 24-hydroxylase activity only slightly, but the concomitant infusion of both chemicals markedly inhibited 24-hydroxylase activity without stimulating 1-hydroxylase activity. These effects of human PTH-(1-34) and cAMP occurred similarly in both the in vitro and the in vivo assays. The present study clearly indicates that besides its well known action in stimulating 1-hydroxylase activity, PTH inhibits renal 25OHD3-24-hydroxylase activity by a mechanism involving cAMP.

24,25-Dihydroxyvitamin D 3↗
PubMed1986

[[Cohort analysis of mortality from three major adult diseases]].

The authors present cohort mortality rates for Japan by five-year age interval for all causes of death and for malignant neoplasms, cerebrovascular disease, and heart disease. The calculations are based on vital statistics data for 1947-1982 and period and cohort life tables for 1891-1982 published by Zenjo Nanjo and Kazumasa Kobayashi. "Ratios of individual cause to all causes in each age were calculated and applied to [a] mortality matrix derived from Nanjo-Kobayashi's life tables. Age-specific period and cohort mortality rates for each cause were calculated from [the] cause-specific mortality matrix.... Trends and age patterns of cohort mortalities and ratios of mortalities in successive cohort and age group were investigated." (SUMMARY IN ENG)

Age Factors↗
PubMed1985

Occurrence of breast cancer in relation to diet and reproductive history: a case-control study in Fukuoka, Japan.

An epidemiologic study on breast cancer in relation to diet and reproductive history was conducted with 3 populations at different levels of risk for the disease: Japanese in Fukuoka, Japan (low risk), Japanese in Hawaii (intermediate risk), and Caucasians in Hawaii (high risk). This report describes the Fukuoka portion of the study. We interviewed 212 patients with histologically confirmed breast cancer and an equal number each of hospital and neighborhood controls to determine risk factors for the disease. The results indicated that "overnutrition" (a high-fat and high-animal protein diet) was not statistically associated with the disease. As noted in previous studies, age at the first birth was positively related to the disease; those women who gave birth to their first child when they were 35 or more years of age showed a relative risk of 5.0 compared with those giving birth at less than 20 years of age. A past history of both natural abortion and of benign breast disease were significantly associated with the disease. On the whole, the results obtained from this Fukuoka portion of study were in good agreement with those from the Hawaii study during which Japanese and Caucasians in Hawaii were investigated.

Adolescent↗