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Biomedical subjects

T Satoh

Publications and source records attributed to T Satoh.

At least 1,279 records · Page 71Linked to original sources
PubMed1982

Metastasis of urothelial tumors of the bladder: correlation between sites and number of organs involved.

Urothelial tumors of the bladder in 2,561 autopsy cases were classified according to the number of organs involved in metastasis, and a comparison was made concerning the frequency of the metastases in various organs. In cases with single organ metastasis, lymph node and lung involvement was low (20% and 14% respectively), but it increased as the number of metastatically involved organs increased. The frequency varied depending on the number of organs involved. Three basic types of metastases were established. Type 1: An increase in metastases was seen rectilinearly in accordance with the number of organs involved. Metastases to the lymph nodes (overall), lungs, liver, bones (overall), rectum and retroperitoneal lymph nodes belonged to this group. Type 2: The frequency was low in cases with metastasis to one or two organs, but markedly increased when three or more organs were involved. Metastases to the adrenals, kidneys and pancreas belonged to this group. Type 3: The frequency was almost unchanged, regardless of the number of organs involved. Metastases to the prostate and perivesical lymph nodes belonged to this group. The number of metastatically involved organs is useful in analyzing the mode of metastasis.

Adenocarcinoma↗
PubMed1982

[Clinical studies on 5-fluorouracil suppository for rectal cancer].

Suppository of 5-Fluorouracil (5-FU) was administered preoperatively to 19 patients with rectal cancer. In the bioassay of 5-FU concentration in the rectal specimens, 5-FU was detected in the wall distant more than 20 cm from the anal ring, in the lymph nodes and in the blood of superior rectal vein. Ten of 19 cases were treated with suppository and 5-FU solution by intravenous injection at the same time, and the other 9 cases with suppository only. In the former group, 6 cases improved remarkably, and 3 cases in the latter group. Remarkable anticancer effect of 5-FU suppository was found in 9 of total 19 cases. Accordingly, it was suggested that the combination use of than suppository alone suppository and the systemic administration of 5-FU was more effective in cancer chemotherapy.

Adult↗
PubMed1981

Experience with free composite tissue transplantation based on the deep circumflex iliac vessels.

Eight free iliac osteocutaneous flaps and three vascularized iliac bone grafts based on the deep circumflex iliac vessels were transferred in 11 cases of large skin and bone or bone defects. Seven of the eight osteocutaneous flaps took successfully. The eighth demonstrated partial necrosis. There was complete bone union in ten cases, and no union in one case as a result of persistent infection. Based on this experience, we concluded that free osteocutaneous flaps based on the deep circumflex iliac vessels have the following advantages over free osteocutaneous flaps based on the superficial circumflex iliac vessels: the pedicle is long (5 to 7 cm); the nutrient vessels are large (artery: 2.2 mm; vein: 2.5 mm); the anatomic course of the vessels is constant; and there is a large amount of bone available.

Adolescent↗
PubMed1981

Dietary therapy in two patients with vitamin B12-unresponsive methylmalonic acidemia.

The biochemical and therapeutic responses to dietary therapy were studied in a 25-month-old girl and a 1-month-old girl with methylmalonic acidemia (MMA-emia), which was unresponsive to vitamin B12. The minimum daily intake of protein which patients could tolerate and display a good development was between 1.0 and 1.2 g per kg body weight. Supplementation with amino acid mixture devoid of toxic amino acids was required to prevent protein malnutrition when daily protein intake was restricted to 0.6 g per kg body weight. Caloric intake should be sufficient, not only to promote growth but also to prevent a rise in MMA level, especially when a patient has ketoacidosis. It was found that MMA excretion per mg creatinine in random urine specimens correlated significantly with serum MMA and twenty four-hour output of MMA per kg body weight. Therefore measurement of MMA in a single urine specimen is useful for evaluating the in vivo accumulation of MMA.

Acidosis↗
PubMed1981

Changes in seizure susceptibility after successive treatments of mice with tryptophol and ethanol.

Changes in leptazol (pentetrazol) seizure susceptibility after successive treatments of mice with tryptophol, a neutral metabolite of indoleamine, in combination with ethanol have been examined. Mice treated with tryptophol plus ethanol became highly susceptible to convulsion. There was little or no difference in seizure susceptibility in mice treated with tryptophol or ethanol alone, compared with the corresponding controls. In the mice treated with tryptophol plus ethanol, a much higher brain tryptophol level was observed, compared with that in mice treated with tryptophol alone. There appeared to be a good correlation between the reduction of the length of the seizure latency time and the time for which the brains were exposed to high levels of tryptophol. These results suggest that elevation of the levels of neutral indoleamine metabolites in the brain may have resulted in the increase in the seizure susceptibility.

Alcoholism↗
PubMed1981

Viral hepatic diseases and microsomal arylamidase activity in liver tissue.

The relationship between microsomal arylamidase activity, determined by a micromethod, and changes of hepatocytes was studied in biopsy samples taken from 107 patients with normal liver histology and viral hepatic diseases. The activities in healthy carriers and chronic persistent hepatitis patients were significantly greater than those of controls, acute hepatitis and chronic active hepatitis patients, and showed a significant greater than those of controls, acute hepatitis and chronic active hepatitis patients, and showed a significant correlation to morphologic criteria. Ultrastructurally, regularly increased smooth endoplasmic reticulum (SER) was found especially in healthy carriers. The arylamidase activity reflects virus-induced changes of the SER in healthy carriers and viral hepatic diseases.

Aminopeptidases↗
PubMed1981

Purification of liver gamma-glutamyltranspeptidase from the rat.

Gamma-glutamyltranspeptidase (GGT) of adult rat liver was solubilized by treatment with papain and further purified by affinity column chromatography on concanavalin-A Sepharose 4B, followed by ion exchange chromatography on DEAE-cellulose. During DEAE-cellulose chromatography, liver GGT was adsorbed at 0.1M Tris-HCl buffer (pH8.0). The Km value of the liver GGT for L-gamma-glutamyl p-nitroanilide was 1.35mM.

Animals↗
PubMed1981

Interaction of lithium and disulfiram in hexobarbital hypnosis: possible role of the 5-HT system.

The effects of lithium and disulfiram on the 5-hydroxytryptamine (5-HT) system and hexobarbital (HX)-induced hypnosis were studied. Treatment with lithium significantly prolonged HX hypnosis. Disulfiram, a potent inhibitor of brain aldehyde dehydrogenase, also produced a prolongation of HX hypnosis. A combination of lithium treatment for 3 days with disulfiram synergistically potentiated the HX hypnosis and reduced the brain HX levels on awakening. Furthermore, L-tryptophan loading significantly increased the HX sleeping time and reduced the brain HX level on awakening in lithium-pretreated rats, whereas it had not effect on HX hypnosis in controls rats. L-Tryptophan also potentiated HX hypnosis in disulfiram-treated rats. The combination of L-tryptophan, lithium and disulfiram caused the greatest prolongation of HX hypnosis. However, no synergism between lithium and disulfiram was observed in animals treated with lithium for 5 days. after 3 days of lithium treatment, the rate of synthesis of 5-HT was elevated, whereas it had returned to the control level after 5 days of lithium treatment. Tryptophan loading increased the rate of synthesis of 5-HT more than 2-fold in control animals. The increase in the rate of 5-HT synthesis caused by lithium was further potentiated by tryptophan loading. These results suggest that lithium and disulfiram exert their synergistic effect on HX hypnosis by acting on the 5-HT system and that an accumulation of 5-hydroxyindoleacetaldehyde, an active metabolite of 5-HT, may be responsible for the increase in the brain sensitivity to barbiturates caused by these drugs.

Animals↗
PubMed1981

[Clinical evaluation of cefotiam in internal medicine, with special reference to infectious disease associated with hematological disorders (author's transl)].

Clinical evaluation of cefotiam (panspolin), a new cephem antibiotics, was performed in the infectious disease associated with hematological disorders and in the respiratory system. In hematological dis orders, 40% of good and 25% of fair results were obtained in clinical effects. In respiratory infections, however, 92% of good results were obtained. Opportunistic infection due to Gram-negative bacilli are often experienced in patients with leukemia. Since cefotiam has sufficient bacteriocidal effects in broad spectrum, it would be a good therapeutic agent against infectious diseases associated with hematological disorders.

Adolescent↗
PubMed1981

Increase of low-Km NADPH-dependent aldehyde reductase activity in the brain by chronic treatment of rats with barbital.

Kinetics studies showed two apparent Km values for p-nitrobenzaldehyde. The high-Km aldehyde reductase (ALR) had a lower Ki value for barbital than the low-Km ALR. The value for maximal velocity (Vmax) for the high-Km ALR was not changed by chronic barbital treatment. However, the Vmax value for the low-Km ALR was significantly increased by chronic barbital treatment. These results suggest that during barbital treatment low-Km ALR which is less sensitive to barbital is induced in compensation for the decreased aldehyde metabolizing capacity of brain.

Alcohol Oxidoreductases↗