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Biomedical subjects

T Satoh

Publications and source records attributed to T Satoh.

At least 1,261 records · Page 70Linked to original sources
PubMed1982

Experimental study on the drainage of so-called intravenous fat pigment from the liver. Long-term observation with histologic, enzyme-histochemical and electron microscopic analysis.

The drainage and decrease of so-called intravenous fat pigment (i.v. fat pigment), which was a lipoid-pigment complex and deposited in the reticuloendothelial system after repeated infusions of Intrafat (intravenous fat emulsion), was observed in the liver of the rabbit by histological, histochemical and electron microscopic methods. As a result, the i.v. fat pigment was mainly found in Kupffer cells immediately after the repeated injections of Intrafat. After then, depending on the period when no injection were given, it decreased gradually and disappeared finally from Kupffer cells. On the other hand, in the interstitium of Glisson's sheath, many phagocytes, extremely swollen and laden with i.v. fat pigment, appeared during the postinfusion period. Furthermore, these phagocytes laden with i.v. fat pigment were found in Glisson's sheath for a long period, although they showed a tendency of decrease. Histochemical and electron microscopic characteristics, quite similar to those of Kupffer cells, suggested that these phagocytes corresponded to the extremely swollen histiocytes or macrophages having some role in the drainage or the metabolism of the i.v. fat pigment.

Animals↗
PubMed1982

Experience of 26 acute renal failure cases.

Data from 26 patients in acute renal failure biopsy have been analysed to define the highest risk factors and to evaluated the reversibility of renal functions. The overall mortality rate was 38 per cent. The mortality (69%) in postsurgical and traumatic cases was significantly higher than that (8%) in cases of obstetrical and medical origin. Survivors and nonsurvivors did not differ in time of initiation of dialysis. There was an increased incidence of gastrointestinal hemorrhage in those who died. A serious underlying disease, infection and gastrointestinal hemorrhage were mainly responsible for deaths. Five of the 16 survivors were left with renal failure and two of them required chronic hemodialysis.

Acute Kidney Injury↗
PubMed1982

[Multiplane postmortem cerebral computed angiotomography--Part I. Normal anatomy of cerebral vessels on the axial plane (author's transl)].

Cranial computed tomography has been mainly used for detection of the parenchymal space-occupying lesion, and has had the limitation of detection of the cerebrovascular lesion itself because of low CT resolution. However, high resolution CT scanners have recently brought us the possibility of definition of fine cerebral vessels on CT images using an appropriate injection method of contrast agents (cerebral computed angiotomography). This paper concerns the normal anatomy of the cerebral vasculature on CT images using 9 fresh cadavers with normal intracranial structures. They received the postmortem injection of contrast agents through bilateral common carotid and vertebral arteries, and were undertaken the multiplane CT scanning with the axial, modified coronal, Towne (half-axial) and the semisagittal projections using GE-CT/T 8800 (9.6 sec scanning time, 320 x 320 matrices). The normal anatomy of cerebral vessels on the axial plane, obtained at the levels 10 to 90 mm above the canthomeatal line, is presented in this paper. Main visualized vessels in the posterior fossa were the basilar artery, the cranial loop of the PICA, the AICA from the origin to the hemispheric branches including the meatal loop in the cerebellopontine angle cistern, and the SCA from the ambient and quadrigeminal segments to the lateral marginal and superior hemispheric branches. The circle of Willis and other main cerebral arteries were clearly visualized with their small branches, for example, the posterior communicating, the anterior choroidal and the lenticulostriate arteries. Deep cerebral veins were also visualized at the levels of the midbrain, the middle and the roof of third ventricle, and the body of lateral ventricle. Postmortem cerebral computed angiotomography provided us not only the precise anatomy of the cerebral vasculatures, but also their anatomic relations with the surrounding structures such as cerebral parenchyma, ventricles, cisterns and other subarachnoid spaces. On the clinical point of view, cerebral computed angiotomography can be applied to the screening system of vascular lesions themselves such as asymptomatic aneurysms, arteriovenous malformations, and Moyamoya disease.

Brain↗
PubMed1982

Effect of hydralazine on hepatic drug metabolizing enzymes in rats.

The effects of hydralazine on hepatic drug metabolizing enzymes were studied in rats. Hydralazine inhibited aminopyrine N-demethylase and aniline hydroxylase in vitro. Kinetic studies indicated that the inhibitory natures of hydralazine were recognized as almost mixed types and a change in difference spectrum demonstrated that hydralazine could bind to cytochrome P-450 as a characteristic type II. A single administration of hydralazine inhibited the drug metabolism, but neither reduction nor induction of the mixed function oxidase system were observed after the hydralazine treatment for 7 days, except the reduction of cytochrome b5 content. In addition, acidophilic degeneration and the formation of acidophilic bodies in liver cells by hydralazine were observed.

Animals↗
PubMed1982

[A case report of traumatic intracerebral pneumocephalus with interesting CT cisternographic findings (author's transl)].

A 19-year-old boy suffered from headache and intermittent CSF rhinorrhea, was admitted to Matsuyama Shimin Hospital on June 1, 1979. Two months prior to admission he had had a frontal head injury with confusion and the right nasal bleeding. Plain skully x-ray films and biplane (axial & coronal) CT revealed intracerebral pneumocephalus in the right frontal lobe with depressed basal skull fracture into the right ethmoid sinus. Clinical conservative courses of intermittent CSF rhinorrhea, headache and vomiting were related to the changes of the air shadow on plain skull films. Preoperative metrizamide CT Cisternography was done on July 5. Sequential CT cisternograms demonstrated ventricular reflux at 1 hr and partial obstruction of the basal cistern and supratentorial subarachnoid space at 3 hr, which attributed to the mass effect of the air cysts. They also demonstrated an interesting finding, the accumulation of metrizamide into the intracerebral air cyst at 3 hr, suggesting transependymal penetration of contrast medium. At 24 hr, the air cyst decreased in size and the metrizamide disappeared. CT cisternograms 8 months after the surgery showed no evidence of air cyst but remained a low dense porencephalic cyst. Ventricular reflux was seen at 3 and 6 hr but there was no accumulation of metrizamide into the cyst at any hr. Filling patterns of the basal cistern and supratentorial subarachnoid space returned normal except the defect in the anterior interhemispheric cistern. Transependymal penetration of metrizamide in this case can be explained by the mechanism of pressure gradient between the ventricle and the air cyst. Thus the postoperative CT cisternograms showed no penetration because of the absence of pressure gradient, whereas the ventricular reflux and the same ependymal septum still remained. No mention has been made about the CSF flow dynamics in intracerebral pneumocephalus and their relation to the CSF rhinorrhea in previous literature. Intermittent CSF rhinorrhea of this case will attribute to the CSF accumulated in the air cyst as mentioned above.

Adult↗
PubMed1982

[Multiplane postmortem cerebral computed angiotomography--Part II. Normal anatomy of cerebral vessels on the modified coronal, Towne and semisagittal planes].

In order to obtain a detailed knowledge of the cerebral vasculature on computed tomographic (CT) images, multiplane CT scannings on the axial, coronal, Towne and sagittal planes are required. Previous reports have concerned only the axial CT images of the cerebral vasculature, and no mention has been made about the vasculature on the coronal, Towne or sagittal images. This paper concerns the normal anatomy of the cerebral vessels on the modified coronal, Towne (half-axial) and semisagittal CT planes using 9 fresh cadavers. They received postmortem injection of contrast agents and were scanned by GE-CT/T 8800 as mentioned in Part I. Scanning planes were the modified 50-60 degrees coronal, Towne (40-45 degrees off the canthomeatal line), and the semisagittal (45 degrees toward the sagittal plane). The main vascular structures visualized on the modified coronal CT plane resembled the antero-posterior view of the carotid angiogram, and they were as follows: internal carotid arteries (supra-clinoid portion), posterior communicating arteries, anterior choroidal arteries, anterior cerebral arteries (horizontal and ascending portions, pericallosal and callosomarginal arteries and other cortical branches), middle cerebral arteries (horizontal, insular, opercular and terminal portions with identification of the angiographic Sylvian point), lenticulostriate arteries, posterior cerebral arteries, basal vein of Rosenthal (BVR), internal cerebral veins (ICV), subependymal veins which drain into BVR and ICV, choroid veins, vein of Galen, and venous sinuses. As for the demonstration of the lenticulostriate arteries or the Moyamoya vessels in clinical cases, the modified coronal plane is preferred to the axial one. On Towne plane, the vertebro-basilar arteries and the ascending portion of anterior cerebral artery were demonstrated as linear densities, which were demonstrated as spotty densities on the axial plane. On the semisagittal plane, the median or paramedian vasculatures of the main cerebral arteries and deep cerebral veins, were well demonstrated like a lateral view of carotid angiogram. Biplane or multiplane cerebral computed angiotomography will increase in clinical diagnostic value for understanding the anatomical relationship between the cerebral vessels and other intracranial lesions, and also will be applied to the screening of small vascular lesions themselves, e.g., asymptomatic aneurysms, vascular occlusions, arteriovenous malformations and Moyamoya diseases.

Brain↗
PubMed1982

[Traumatic interhemispheric subdural hematoma--report of a case and analysis of 7 cases].

A case of traumatic interhemispheric subdural hematoma is reported and 7 cases, including ours, reported in literature are analyzed. A 43-year-old jogger hit his forehead in the traffic accident. After medical care for the wound at the near hospital, he walked to home without any neurological deficits. On the following day, he complained of headache, nausea and slight gait disturbance, so the visited us 5 days after head trauma. On the biplane computed tomograms, interhemispheric subdural hematoma was detected. A distinct avascular space in this portion was found on the right carotid angiograms. Treated conservatively with repeated computed tomography, he recovered completely well about a month after head trauma. Analyzing 7 cases, following comments were obtained; Age distribution was between 23 to 74 and all were male. The mechanism of the hematoma formation in such region remained still unclear, but seemed to be caused partially due to rotational cerebral injuries. Characteristic clinical symptom was hemiparesis, predominantly crural or crural monoparesis. This symptom was found in four of seven cases on the same side of the hematoma, that was supposed due to the compression of the contralateral blood flow the distal anterior cerebral artery. Neuroradiologically, on the angiograms, the internal branches of callosomarginal arteries turned away from the middle parallel to the pericallosal artery stayed in the middle and between them, a distinct avascular space was found. On the biplane computed tomograms, semilunar high density area was identified along the midline, bounded medially by the falx cerebri, laterally by the convex border against the brain parenchyma, inferiorly by the tentorium. Although the anteroposterior extension of the hematoma was recognized on the axial plane, the superoinferior extension, especially in relation to the tentorium, was well shown on the coronal plane. On the electroencephalogram, no characteristic findings were obtained. Abnormalities blood coagulation were found in a case. Five cases were operated on and 2 cases treated conservatively, and the outcome was good in all. The following diseases had to be differentiated: hematomas due to the rupture of peripheral anterior cerebral artery aneurysms, including traumatic ones, blood coagulopathy or medication of anticoagulants. Tumors such as parasagittal or falx meningiomas, subdural abscesses localized in the interhemisphere, infarctions of distal anterior cerebral artery.

Adult↗
PubMed1982

Distant metastasis of urothelial tumors of the renal pelvis and ureter.

Autopsy reports on urothelial tumors of the renal pelvis and ureter in 602 cases were analyzed to investigate the mode of metastasis. Seventy one cases, or 12%, showed no metastasis. Metastasis-free cases occurred with significantly high frequencies in cases of tumors of the ureter and papillomatosis, and less frequently in squamous cell carcinoma cases and in females. Lymph nodes were the most frequent site of dissemination, especially the retroperitoneal and para-aortic lymph nodes. Metastases to the lungs, peritoneum and ipsilateral adrenal were significantly more frequent in cases of tumors of the renal pelvis than in those of tumors of the ureter. Metastases to the retroperitoneal lymph nodes and peritoneum were frequent in cases with metastasis to one organ. Radical nephrectomy with regional lymphadenectomy and/or radiation therapy is indicated for tumors of the renal pelvis. Palliative surgery or nephroureterectomy with a cuff of bladder wall is indicated for tumors of the ureter or papillomatosis, and radical nephroureterectomy with regional lymphadenectomy and/or radiation therapy in cases where a pronounced tendency of down-growth invasion is suspected.

Adenocarcinoma↗
PubMed1982

[An interesting case of the traumatic middle meningeal arteriovenous fistula].

The authors reported an interesting case of the traumatic middle meningeal arteriovenous fistula which was caused by the minor head injury on the opposite side complicated with a subarachnoid hematoma, and was completely cured 35 days after head injury without any surgical intervention. A 75-year-old woman fell down after unconsciousness fit and hit her right head, then visited Matsuyama Shimin Hospital complaining of nausea, vomiting and severe left temporalgia. Neurologically, no other abnormalities were found. On plain skull roentogenograms, a linear fracture was noted on the right temporal bone, but not on the left side. A subarachnoid hematoma localized in the left Sylvian fissure was identified on plain computed tomograms. Left carotid angiograms revealed the middle meningeal arteriovenous fistula at the left middle fossa, which showed an characteristic drainages, i.e. mainly draining to the pterygoid venous plexus and the superior sagittal sinus, partially to the cavernous sinus. She was admitted to our ward and was treated only conservatively. Thirty-five days after head injury, her complaints improved remarkably and left carotid angiograms, performed on the next day, disclosed complete disappearance of the previous fistula, and suggested the point of fistula clearly. Documenting the computed tomogram and the angiograms of our case, possible mechanism of fistula formation and its spontaneous cure was discussed. The middle meningeal arteriovenous fistula was formed by the interaction between the direct or indirect influence of head injury and anatomical, histological and pathological factors of meningeal vessels themselves. Spontaneous cure of the fistula resulted from thrombosis at the point of fistula. In our case, irregularity of the wall of anterior middle meningeal artery on the repeated angiograms supported this view.

Aged↗
PubMed1982

Transport of L-cysteine and reduced glutathione through biological membranes.

Comparative studies were carried out on in vivo and in situ absorption in rats and in vitro uptake by red cells of L-cysteine (CySH) and reduced glutathione (GSH). After oral administration of CySH, the plasma and liver CySH levels and liver GSH level significantly increased, but the plasma GSH level did not. In contrast to the results with CySH, when GSH given orally at a dose equivalent to that of CySH either on a weight or molar base, no increase in the levels of GSH was observed at either dose level. In a rat small intestine recirculation system in situ, CySH added to the recirculation perfusate disappeared progressively with time from the perfusate, indicating that transportation occurred across the intestinal wall, but with GSH such disappearance was not observed. CySH was taken up well by rabbit erythrocytes in vitro, but GSH was not. It was concluded, therefore, that CySH passes through biological membranes and serves as a good source of SH groups, whereas GSH is ineffective when given orally because of its poor absorption from the digestive tract and/or poor ability to permeate through the membrane.

Animals↗
PubMed1982

Renal function after nephrectomy in renal donors.

Six months to 5 years after nephrectomy in renal donors, creatinine clearances and PSP tests of 34 cases had recovered to 81.8% and 68.2% respectively of prenephrectomy performance. Blood urea nitrogen, creatinine and uric acid levels had increased to 24.9%, 36.7% and 24.3% respectively of prenephrectomy values. There was compensatory hypertrophy of the remaining kidney. The mean increase in size of the remaining kidney was 12.0% x 17.8%. There were early complications in 11 (32%) of the donors, in the form of pneumothorax in six cases, wound infection in two cases, hepatitis in two cases and urinary tract infection in one case. There was one late complication of neuralgic pain in the scar region.

Adult↗