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Biomedical subjects

T Satoh

Publications and source records attributed to T Satoh.

At least 1,207 records · Page 67Linked to original sources
PubMed1984

Autopsy findings in postoperative acute renal failure patients, collected from the annuals of pathological autopsy cases in Japan.

Autopsy findings in post-surgical acute renal failure cases were studied in 131 cases on diaysis collected from annuals of pathological Autopsy Cases in Japan (1958-1981). Fifty (38.2%) abdominal and 48 (36.6%) cardiovascular operative procedures were the origins of the 131 post-operative acute renal failure patients treated by dialysis. The incidence of acute tubular necrosis was 68.7 per cent. There were 13 non-obstetric cases (19.9%) of acute bilateral cortical necrosis. Direct causes of death in postsurgical acute renal failure patients were mainly infection (61.7%) and bleeding (21.0%) The incidence of patients with infectious disease complicating postsurgical acute renal failure was 60.3 per cent and the rate of those between 20 and 70 years of age was constant. The incidence of patients with bleeding was 45.0 per cent and no significant differences were seen in the 20-70 year age range.

Acute Kidney Injury↗
PubMed1984

Autopsy findings in diabetic nephropathy patients under dialysis, collected from the annuals of pathological autopsy cases in Japan.

Collected from the Annuals of Pathological Autopsy Cases in Japan (1958-1980), autopsy findings of diabetic patients under dialysis were studied in 103 cases on peritoneal dialysis and 103 cases on hemodialysis. Direct causes of death in 13 cases (12.6%) of the 103 diabetic patients on peritoneal dialysis and in 8 cases (7.8%) of the 103 diabetic patients on hemodialysis was infections, and in seven cases (6.8%) on peritoneal dialysis and 19 cases (18.4%) on hemodialysis was bleeding. The incidence of bleeding in diabetic patients on hemodialysis was significantly higher than that in peritoneal dialysis cases (p less than 0.025). Other direct causes of death in diabetic patients on dialysis included myocardial infarction, uremia, pulmonary edema, liver cirrhosis and carcinoma. No significant difference was seen between peritoneal dialysis and hemodialysis, except the incidence of complications of bleeding and pericarditis.

Adult↗
PubMed1984

Autopsy findings in dialysis patients with polycystic disease of the kidney.

Autopsy findings of 98 dialysis patients with polycystic disease of the kidney were studied. The 50-59 year-old group was the largest as well as the 1000g-1990g group of kidney weight. Death due to infections was the most frequent, followed by bleeding. The total number of patients with infections and bleeding was 39 cases (39.8%) and 38 cases (38.8%), respectively. Brain and subarachinoid bleeding seemed to be the most important risk factors. But, the causes of death were nonspecifically related to polycystic renal disease. The total number of patients with polycystic disease of the liver was 51 cases (57.1%) and the mean weight of liver was 1960.2g.

Adult↗
PubMed1983

Some dorsal raphe axons of the cat bifurcate to project into bilateral medial forebrain bundles.

Seventy-one dorsal raphe (DR) neurons of the cat were antidromically activated by electrical stimulation of the medial forebrain bundle (MFB). It was found that not a small number of DR neurons send their axons contralaterally. Seven out of 67 DR neurons (10.4%) responded to stimulation of both sides of MFB. Positive collision test for the bilaterally evoked responses indicates that single axons of these DR neurons bifurcate to innervate bilateral forebrain structures.

Animals↗
PubMed1983

Simultaneous determination of tegafur and 5-fluorouracil in serum by GLC using nitrogen-sensitive detection.

A sensitive assay of both tegafur (I) and 5-fluorouracil (5-FU) using GLC with a nitrogen-phosphorus-sensitive detector is described. The drugs were extracted from rabbit serum with ethyl acetate and methylated with diazomethane. Linearity was obtained over the concentration ranges of 3.13-200 micrograms/ml for I and 0.0313-2 micrograms/ml and 10-50 ng/ml for 5-FU. The detection limits of I and 5-FU in serum were 50 and 8 ng/ml, respectively. The serum concentrations of the drugs determined by the present method closely agreed with those obtained by spectrophotometry for I and microbial assay for 5-FU.

Animals↗
PubMed1983

Spontaneous closure of a traumatic middle meningeal arterio-venous fistula.

A case is reported of a traumatic middle meningeal arteriovenous fistula, which was formed on the contralateral side to the head injury without a skull fracture and was no longer demonstrable on the repeated angiogram after 35 days without any surgical intervention. Possible mechanisms of fistula formation and its spontaneous closure are discussed.

Aged↗
PubMed1983

Purification and comparison of glutamine synthetase from chicken liver, brain and neural retina.

Glutamine synthetase (L-glutamate: ammonia ligase, EC 6.3.1.2) was isolated from chicken liver, brain and neural retina. The specific activities of the purified enzyme preparations from the three different sources were similar. They were composed of subunits of the same molecular weight (43 K) and were immunologically indistinguishable. Slight differences were detectable among them in relation to the amino acid compositions and regulation of their activities by the several effectors tested.

Amino Acids↗
PubMed1983

Sex-related difference in the hepatic glutathione level and related enzyme activities in rat.

Age and sex differences in the hepatic glutathione level and related enzyme activities in rats of both sexes were investigated. At 7 weeks of age there was no significant difference in GSH levels between males and females, although a higher level of intracellular GSH was observed in male rats at 12 weeks of age. Hepatic gamma-glutamyl transpeptidase activities were significantly higher in females than in males at only 7 weeks of age. Glutathione peroxidase showed higher activities in females than in males. Conversely, glutathione S-transferase, glutathione reductase and glutathione synthesis rates were markedly higher in males than in females.

Aging↗
PubMed1983

Production of nitrous oxide from nitrite in Klebsiella pneumoniae: mutants altered in nitrogen metabolism.

Under anaerobic conditions, Klebsiella pneumoniae reduced nitrite (NO2-), yielding nitrous oxide (N2O) and ammonium ions (NH4+) as products. Nitrous oxide formation accounted for about 5% of the total NO2- reduced, and NH4+ production accounted for the remainder. Glucose and pyruvate were the electron donors for NO2- reduction to N2O by whole cells, whereas glucose, NADH, and NADPH were found to be the electron donors when cell extracts were used. On the one hand, formate failed to serve as an electron donor for NO2- reduction to N2O and NH4+, whereas on the other hand, formate was the best electron donor for nitrate reduction in either whole cells or cell extracts. Mutants that are defective in the reduction of NO2- to NH4+ were isolated, and these strains were found to produce N2O at rates comparable to that of the parent strain. These results suggest that the nitrite reductase producing N2O is distinct from that producing NH4+. Nitrous oxide production from nitric oxide (NO) occurred in all mutants tested, at rates comparable to that of the parent strain. This result suggests that NO reduction to N2O, which also uses NADH as the electron donor, is independent of the protein(s) catalyzing the reduction of NO2- to N2O.

Electron Transport↗
PubMed1983

Species difference in glutathione level and glutathione related enzyme activities in rats, mice, guinea pigs and hamsters.

Total glutathione (GSH and GSSG) level, and the activities of gamma-glutamylcysteine synthetase, gamma-glutamyltranspeptidase (gamma-GTP), glutathione S-transferase (GST), glutathione peroxidase (GSH-Px) and glutathione reductase (GR) in the liver were investigated in rats, mice, guinea pigs and hamsters. Hepatic GSH level in rats, mice, guinea pigs and hamsters were 7.1, 7.8, 3.5 and 5.4 mM, respectively. The lower level of GSH in guinea pigs seems to be in part attributed to the higher activity of hepatic gamma-GTP, an enzyme which catalyzes GSH breakdown. Moreover, a marked species difference in the activities of GST, GSH-Px and GR was also observed. A 48 h-fasting resulted in a decrease of GSH and GSSG levels in rats, mice and guinea pigs, but not in hamsters. In addition, both nicotineamide adenine dinucleotide phosphate- and ascorbate-dependent lipid peroxidation produced by 9000 X g supernatant fraction in fasted animal species occurred most highly in the rat followed by hamster and guinea pig, and almost undetectable in mice. Thus, it suggests that the occurrence of lipid peroxidation in fasted animals may not be related to the hepatic GSH level, and rather, a lack of occurrence of lipid peroxidation in fasted mice may be due to the increased activity of GSH-Px activity.

Animals↗
PubMed1983

Studies to increase the antitumor activity of 1-(tetrahydro-2-furanyl)-5-fluorouracil and its metabolic aspects by combined administration with L-cysteine.

The plasma and liver concentrations of both 1-(tetrahydro-2-furanyl)-5-fluorouracil (FT) and 5-fluorouracil (5-FU), an active metabolite of FT, increased very markedly after administration of FT (500 mg/kg, p.o.) combined with L-cysteine (L-CYS, 500 mg/kg, i.p. or p.o.) when compared to FT alone in rats. On the other hand, the oral acute toxicity of FT was also enhanced with the combined administration of FT and L-CYS. There was no difference in the in situ absorption rate of FT from the small intestine between rats treated with L-CYS (500 mg/kg, i.v.) and vehicle-treated controls. The inhibition of the disappearance of FT and the increase of the formation of 5-FU was observed in vitro after incubation of FT with liver microsomes from rats treated with L-CYS (500 mg/kg, p.o.) when compared to vehicle-treated controls. The presence of L-CYS significantly inhibited the in vitro degradation of 5-FU by non-treated rat liver homogenate. In the drug metabolizing enzyme activity of rat liver microsomes, aniline p-hydroxylase activity was inhibited, but aminopyrine N-demethylase activity was conversely activated by the combined administration of FT and L-CYS, but not by FT alone; furthermore, no change of cytochrome P-450 content was observed. In sarcoma 180 bearing mice, the oral antitumor activity of FT in combination with L-CYS (500 mg/kg, i.p. or p.o.) was about 1.1-2.0 times higher than that of FT alone. It was concluded from these findings that the drug metabolizing enzymes in liver involved in the conversion of FT into an active metabolite, 5-FU, are influenced by the combined administration of FT and L-CYS to give an increased organ level of 5-FU; and this resulted in the enhancement of the antitumor activity of FT.

Absorption↗
PubMed1983

Dietary therapy in a girl with propionic acidemia: supplement with leucine resulted in catch up growth.

A 15-month-old girl with propionic acidemia presented a failure to thrive and muscular hypotonia, who had been treated with diets low in leucine, valine, isoleucine, threonine and methionine. Supplementation with leucine gave her a catch up growth and brought about an improvement in muscular hypotonia in parallel with restoration of plasma leucine which had been below normal range during the treatment with the above diets. Oral loading test of leucine produced no ketoacidosis. These findings indicate that the restriction of leucine is not necessary in the dietary management of propionic acidemia.

Amino Acid Metabolism, Inborn Errors↗
PubMed1983

Disappearance and development of cerebral aneurysms in moyamoya disease. Case report.

The authors report a case of multiple cerebral aneurysms associated with moyamoya disease, in which the reduction and disappearance of bilateral internal carotid artery aneurysms and the new development and enlargement of bisilar artery aneurysms were demonstrated on sequential cerebral angiograms. Possible mechanisms of the spontaneous disappearance and development of cerebral aneurysms in association with moyamoya disease are discussed.

Adult↗