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Biomedical subjects

T Rufli

Publications and source records attributed to T Rufli.

At least 73 records · Page 4Linked to original sources
PubMed1988

[Infiltrating lymphadenosis benigna cutis as borreliosis of the skin].

Forms of lymphadenosis benigna cutis (Lbc) which run an unusual course may present considerable problems and are sometimes difficult to distinguish from malignant lymphomas of the skin on the basis of the clinical and histological picture. The case of a female patient is reported, who presented with plaque-like infiltrative lesions on both lower arms. The lesions were interpreted as being malignant lymphomas of the skin. After a progressive course of 6 years' duration, the diagnosis of an unusual plaque-like infiltrative form of Lbc caused by Borrelia was serologically confirmed by the demonstration of anti-Borrelia burgdorferi antibodies. Immunohistochemical examinations yielded the picture of a follicular pseudolymphoma with the formation of germ centres. After several weeks of penicillin therapy the skin lesions cleared completely.

Aged↗
PubMed1988

[Facial granuloma. On the clinic-histologic extent of variations of finding in 5 patients].

The clinical and histopathological findings are presented in five patients with granuloma faciale. The lesions most often occur on the face and are characterized by single or multiple soft, elevated, well-circumscribed nodules or plaques ranging in color from reddish purple to brown. The sites most commonly affected are the nose, temple, checks and forehead. The etiology of granuloma faciale is unknown. The condition is extremely persistent and may last for many years. Histologically, a narrow zone of uninvolved dermis is usually observed between the epidermis and the dermal, dense, polymorphous infiltrate at all levels of the corium. The infiltrate is usually diffuse or shows a nodular perivascular pattern, consisting of lymphocytes, plasma cells, neutrophils and histiocytes together with a varying number of eosinophils. In older lesions the formation of the fibrous tissue may be seen, accompanied by capillary proliferation. Differential diagnosis includes sarcoidosis, discoid lupus erythematosus, erythema elevatum et diutinum, angiolymphoid hyperplasia with eosinophilia and histiocytosis X. The diagnosis of granuloma faciale requires a synopsis of clinical and histological findings.

Adult↗
PubMed1987

Erythema chronicum migrans: evidence for cellular immune reaction in the skin lesion.

Skin biopsy specimens from 9 patients with erythema chronicum migrans (ECM) were studied immunohistochemically using a series of monoclonal antibodies. In biopsy specimens taken from the erythematous peripheral portion of ECM the perivascular infiltrates were composed predominantly of LEU-4+ T cells. LEU-3a + helper/inducer T cells were more numerous than LEU-2a + cytotoxic/suppressor T cells. Of particular interest was the high number of LEU-6+ Langerhans cells in the epidermis and dermis of specimens taken from the erythematous portion of ECM as well as from the noninflammatory skin outside the erythema. The presence of LEU-6+ Langerhans cells and T cells in the ECM lesions suggests that, apart from humoral factors, a cell-mediated immune response directed against Borrelia burgdorferi antigen is important as well in the pathogenesis of this disease.

Borrelia Infections↗
PubMed1986

[Skin problems in joggers].

Reports on skin problems in joggers are rare in medical literature. Jogger dermatoses are caused by repeated trauma, mechanic overuse, thermic effects, allergic-toxic reactions and infectious processes. Most common are bullosis mechanica, piezogenic papules, hyperkeratosis haemorrhagica and subungual haematomas. Contact allergies and infections such as athlete's foot, pitted keratolysis and pyoderma are well-known complications in joggers. Frostbite and actinic damage, abrasions of the nipples, collisions with vehicles and injuries by buzzards are further possible incidents to be reckoned with occasionally. In most cases, prophylaxis is possible by training adaptation and use of adequate footwear. Jogger dermatoses usually clear after a suitable jogging-free interval.

Athletic Injuries↗
PubMed1986

[Enlarged spectrum of tick transmitted spirochaetoses].

After the successful identification of Borrelia burgdorferi as the cause of Lyme disease, a new tick-borne infection occurring in the United States, almost identical spirochaetes have been isolated from the tick Ixodes ricinus in Europe. As a result, the spirochaetal aetiology of skin diseases, which had long been recognized as tick-borne infections, namely erythema chronicum migrans with its neurological complications of the tick-borne meningopolyneuritis of Garin-Bujadoux-Bannwarth, acrodermatitis chronica atrophicans and lymphadenosis cutis benigna, could be confirmed by means of microbiological, histological and serological methods. On the basis of case histories it had already been assumed for some time that anetodermia maculosa and the localised sclerodermas might also be caused by a tick-borne agent. The results of serological investigations have now strengthened this assumption, although microbiological confirmation is still lacking.

Acrodermatitis↗
PubMed1985

[Clinical evaluation of the Gonozyme enzyme immunoassay in comparison with the modified Thayer-Martin medium and the Jembec transport medium].

A solid phase enzyme immunoassay (GC-EIA, Gonozyme Abbott) for detection of Neisseria gonorrhoeae was tested in 185 male patients with urethritis purulenta sive serosa, and compared with the results obtained by bacterial culture. In 69 men gonorrhoea was confirmed by bacterial culture as method of reference. In 60 patients detection of Neisseria gonorrhoeae was carried out by means of direct inoculation on to Thayer Martin selective medium and immediate incubation, as well as on Jembec transport medium, which was mailed once a day to the respective laboratory. In 8 cases, N.go. was diagnosed with the Thayer-Martin medium only, in 1 case with the Jembec medium only. In 68 out of the 69 patients (sensitivity 98.6%) diagnosis was established with Gonozyme. An additional 8 positive results were obtained with this test, which could not be confirmed by bacterial culture (specificity 93.1%). 2 of these so-called false positive results can with great probability be assessed as true positive results on the basis of the case history. The positive predictive value with the Gonozyme method was 81.5% and the negative predictive value was 99.1%. The advantages, disadvantages and indication for this method are discussed and compared with the experience of other authors to date.

Adult↗
PubMed1985

Bowenoid papulosis. Presence of human papillomavirus (HPV) structural antigens and of HPV 16-related DNA sequences.

This study reviews 39 cases of anogenital bowenoid papulosis lesions in 22 individuals of both sexes that were analyzed clinically, histologically, immunocytochemically, and virologically. Macroscopically, three different types of lesions were demonstrated: erythematous macules; papules (lichenoid and/or pigmented papules); and leukoplakialike lesions. Microscopically, bowenoid papulosis fulfills the criteria of a squamous cell carcinoma in situ. Much like oral precancers, three distinct growth patterns (flat, endophytic, and exophytic) could be differentiated, which did not correlate with the clinical aspect of the lesions. In only two (5.12%) of the 39 cases of bowenoid papulosis could structural antigens of papillomaviruses be detected immunocytochemically (peroxidase-antiperoxidase technique). The DNA from 12 lesions that were analyzed for the presence of papillomavirus-specific sequences hybridized stringently in all cases with the human papillomavirus 16 specific DNA probe labeled with phosphorus 32.

Adolescent↗
PubMed1984

[The differential diagnosis of indolent ulcers upon return from the Tropics: frambesia].

A 26-year-old patient was referred for investigation of chronic skin ulcerations which had appeared 2 months after a one-week stay in the Ivory Coast. The diagnosis was established clinically and serologically and the patient was successfully treated with penicillin. Even if yaws is a rare imported disease in Switzerland, it should always be considered in differential diagnosis of painless skin ulcerations in travellers returning from tropical countries, bearing in mind that the number of cases of yaws has increased in several tropical countries.

Adult↗
PubMed1984

T-cell subsets in acne rosacea lesions and the possible role of Demodex folliculorum.

Skin biopsy specimens from 4 patients with typical acne rosacea lesions were examined for the presence of T-cell subsets using monoclonal antibodies. The infiltrates consisted chiefly of LEU-1 reactive T cells with a predominance of LEU-3a antibody positive helper-inducer T cells, while LEU-2a staining suppressor-cytotoxic T cells were scarce. These cells penetrated regularly into the follicular wall and the epidermis. The study showed that most T cells in the dermal granulomatous infiltrates around Demodex parts, which were displaced extrafollicularly, were helper-inducer T cells. The predominance of helper-inducer T-cell subsets in the dermal infiltrates of acne rosacea lesions in frequent association with Demodex supports the hypothesis that a cell-mediated immune response plays an important role in the pathogenesis of rosacea.

Adult↗