[Innovations in the diagnosis and therapy of gonorrhea].
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Biomedical subjects
Publications and source records attributed to T Rufli.
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40 women were treated for uncomplicated genital gonorrhoea, verified by culture, with a single oral dose of 1,200 mg rifampicin (Rimactan). The ages ranged between 15 and 51 years. In 33 patients that could be evaluated, the gonorrhoea was cured. In 8 of 18 patients the preexistent vaginal discharge improved. 4 women experienced six different side effects which were probably related to rifampicin. The 1,200-mg rifampicin oral one-dose treatment is a reliable, efficient, and well-tolerated therapy of uncomplicated gonorrhoea in women.
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After an historical survey, the various modern serologic tests for syphilis are dealt with. The humoral immunological phenomena, which develop in a certain chronological order, antilipoidal (non-specific) and antitreponemal (specific) antibodies of the classes IgM and IgG are presented. Particularly the demonstration of specific antitreponemal antibodies of the IgM class has opened up new perspectives in the serologic diagnostics of syphilis. For the present, screening examinations and the confirmation of the diagnosis are the domain of the specific tests (TPHA, FTA), while for the assessment of the therapy effect and of reinfection the unspecific tests (VDRL) are still to be employed.
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