Search PubMed⌕ Search

Biomedical subjects

T Oda

Publications and source records attributed to T Oda.

At least 739 records · Page 41Linked to original sources
PubMed1982

Left ventricular hypertrophy in non-rheumatic myocarditis in children.

Fifty-three Japanese children with non-rheumatic myocarditis were investigated with regard to left ventricular hypertrophy (LVH), which was assessed electrocardiographically. Follow-up periods ranged from 12 to 58 months with a mean of 22.8 months. Left ventricular posterior wall thickness (LVPWT) evaluated echocardiographically was compared to the electrocardiographic findings of LVH. The overall prevalence of LVH was 30.2% (16 patients). In 3 patients, LVH was detected during the first examination. In the other patients, however, LVH was detected later during the follow-up periods. In all but 2 patients, LVH disappeared during the follow-up periods. The development into hypertrophic cardiomyopathy was evident in only one patient. The LVPWT showed no definite relation to the presence of LVH. Thus, LVH on an electrocardiogram appears to be a common finding in children with non-rheumatic myocarditis.

Cardiomegaly↗
PubMed1982

Pharmacokinetic analysis of adriamycin (doxorubicin) and related fluorescent compounds in Ehrlich tumor-bearing mouse plasma and tissues.

Pharmacokinetic analysis of the distribution and concentration of adriamycin (ADM) in mouse plasma and tissues was carried out by differentiating the unmetabolized form from metabolized ones using high-performance liquid chromatography after a single intravenous injection. Marked differences between ADM and total ADM equivalent values (total ADM values) or its metabolized forms were observed in the pharmacokinetic behavior in plasma and tissue distributions. The ratios of tissue per plasma for total ADM and for ADM values in the liver, kidney and heart showed a two-digit magnitude each time they were examined. Twenty four h later, the ratios for ADM values in the liver, kidney, heart and lung were at high levels; 43.1, 48.1, 57.9 and 45.5 times, respectively. Twenty min after injection the ratios for total ADM values in the spleen, lung and tumors were comparatively small, but 24 h later, the ratio had increased 36.5, 45.5 and 6.8 times respectively.

Animals↗
PubMed1982

[Evaluation of the clinical effect and tissue distribution of piperacillin in the field of obstetrics and gynecology].

Piperacillin (PIPC) was administered to patients with obstetrical and gynecological infectious diseases and we studied its clinical effect and tissue distribution. 1. Clinical results. PIPC was administered to 26 patients at a dose of 2--4 g per day (twice a day) by dripping infusion over a period of 3--10 days (total 8--30 g). These included 16 cases with intrauterine infection, 1 with adnexitis, 4 with pelvic inflammatory disease and 5 with infections of the external genitalia. The clinical results were excellent in 11 cases, good in 13 cases and poor in 2 cases so that the overall efficacy rate was 92.3%. For bacteriological study 33 strains were isolated from 20 patients. These included Gram positive bacteria (6 strains), Gram negative bacteria (23 strains) and anaerobes (4 strains). After PIPC treatment 32 strains (including S. epidermidis 4 strains, E. coli 12 strains, K. pneumoniae 3 strains, E. aerogenes 2 strains, P. aeruginosa 2 strains and anaerobes 4 strains, etc.) disappeared except for 1 strain of K. pneumoniae which persisted. The disappearance rate was 97.0%. The only side effect observed was a slight case of malaise during the first administration day, however the relationship between the appearance of this symptom and the drug was unclear. No adverse reaction in laboratory findings was observed. 2. Tissue distribution. We determined the tissue concentration from 90 to 240 minutes after dripping infusion for 1 hour at a dose of 2 g. PIPC concentrations in these tissues including the endometrium, myometrium, cervix uteri, portio vaginalis, oviduct and ovary showed the highest level (18.0--11.7 micrograms/g) at 90 minutes after the beginning of administration. These values were 48.6--31.6% in respect to the uterine arterial blood level (37 micrograms/ml at 90 minutes after infusion).

Adult↗
PubMed1982

Effects of the tumor promoter teleocidin on human hepatoma cells in tissue culture.

The tumor promoter teleocidin inhibited the proliferation of human HUH hepatoma cells in tissue culture. HUH cells cultured with teleocidin developed elongated cytoplasm. In addition, these biological effects of teleocidin were associated with a remarkable decrease in the amount of cellular fibronectin. The synthesis of structural proteins and the number of cell surface receptors for epidermal growth factor were not altered in cells treated with teleocidin, suggesting that teleocidin acted selectively on some of the cellular constituents such as fibronectin. The present data also suggest a possible relationship between the cellular fibronectin content and the biological characters of HUH cells.

Alkaloids↗
PubMed1982

[Diagnostic evaluation of progesterone challenge test in amenorrheic patients (author's transl)].

Diagnostic evaluation of progesterone (P) challenge test (menstrual response and serum LH changes after P administration) was studied in 223 patients with secondary amenorrhea. Based on the serum FSH an prolactin (PRL) values amenorrheic patients were divided into three major groups; low or normal levels of FSH and PRL (Group I), high levels of PRL (Group II), high levels of FSH (Group III). Serum estradiol levels in patients with normal menstrual response to P were significantly higher than those with absent or scanty bleeding following P. Although the Group III patients with absent or scanty bleeding (Group IIIb) represented patients with ovarian failure, those with normal menstrual response to P (Group IIIa) clinically appeared to have high developed ovarian follicles. Based on the LH responses after P administration the Group I patients were further subdivided into two groups, one with LH increase following P (Group Ia) and the second with no LH increase (Group Ib). In Group Ia 92 percent ovulated with clomiphene but all in Group Ib failed to ovulate. Therefore the LH changes after P administration gave good prediction of ovulatory as well as anovulatory responses to clomiphene.

Adolescent↗
PubMed1982

Squamous cell carcinoma arising from an epidermoid cyst in the ovary of a rat treated with 7,12-dimethylbenz[a]anthracene.

Primary non-teratomatous ovarian squamous cell carcinomas are very rare. A case of rat ovarian squamous cell carcinoma has been found in which the tumor arose from a squamous element in the ovary. Squamous epithelial aggregates were found in the wall of a cyst and on serial section, the cyst was found to be unaccompanied by any teratomatous components and showed a thin squamous epithelial lining with keratinizing debris. On the basis of these findings, it was suggested that the squamous element was a rat ovarian epidermoid cyst from which a squamous cell carcinoma arose, presumably by a direct carcinogenic effect of 7,12-dimethylbenz[a]anthracene.

9,10-Dimethyl-1,2-benzanthracene↗
PubMed1982

[Induced rat ovarian carcinoma showing mainly squamous components--an experimental approach to common epithelial tumors].

Female Wistar strain rats were treated with a chemical carcinogen DMBA (7,12-Dimethylbenz (a) anthracene) implanted directly into their ovary. In this method of tumor induction, adenocarcinoma commonly developed in the ovary by the direct carcinogenic effect of DMBA during a 30 weeks observation period. However, two cases of primary ovarian carcinoma showing mainly squamous components have been found in a recent experiments. The histological characteristics of these indicated that they were adenoacanthoma and adenosquamous cell carcinoma and both were derived ultimately from the ovarian surface epithelium with interposition of endometrioid type tumor. These two cases of experimental rat ovarian cancer consist of mainly squamous element are studied morphologically and their histogenesis is discussed.

9,10-Dimethyl-1,2-benzanthracene↗
PubMed1982

Non-A, non-B hepatitis in experimentally infected chimpanzees with the NIH strains F and H.

The NIH strains F and H of non-A, non-B hepatitis were studied by transmission to chimpanzees. They developed biochemical and ultrastructural evidences of non-A, non-B hepatitis. Chimpanzee's plasma containing the strain F was passaged further three times in the present study, and the results were identical to the original report made by SHIMIZU et al. In contrast to the original report, however, the prototype strain H inoculum or human plasma supposedly containing only the strain H, induced both SHIMIZU's cytoplasmic and nuclear changes in one chimpanzee. This result may pour further oil on the flame of recent controversy regarding the sequestration of the strains H and F, but we believe at present that the strains H and F are separate infectious agents. This is based on the fact that the strain F never induced SHIMIZU's nuclear changes, and our detection of an additional infectious agent of non-A, non-B hepatitis identical to the NIH strain H. We suspect the NIH strain H inoculum provided to us was contaminated by the strain F. The conclusion of controversy regarding the strain H should await for further studies including a further cross challenge study between the strain H and the strain F. Ultrastructural changes of the chimpanzee's liver associated with non-A, non-B hepatitis are described.

Alanine Transaminase↗
PubMed1982

Epidemiological analysis of the distribution of antibody to adult T-cell leukemia-virus-associated antigen: possible horizontal transmission of adult T-cell leukemia virus.

About 20% of healthy inhabitants in the endemic area of adult T-cell leukemia/lymphoma (ATL) in Nagasaki Prefecture showed a positive antibody to adult T-cell leukemia virus (ATLV)-associated antigen (ATLA), while none of the inhabitants in a non-endemic area in Aichi Prefecture showed a positive anti-ATLA. The age-specific positive rate of anti-ATLA in the endemic area increased with age, especially in females. The positive rate of anti-ATLA among inhabitants older than 40 years was 21% in males and 36% in females. From epidemiological analyses of the mode of anti-ATLA reactivity among married couples and some family members and relatives with positive and negative anti-ATLA, two routes of transmission of ATLV were suggested. One route is from parents to children, either vertically or horizontally, and the other route is horizontal transmission between spouses, especially from husband to wife. The presence of some vectors of ATLV in the endemic area of ATL is discussed.

Adult↗
PubMed1982

[The method for the measurement of the binding capacity of androgen binding protein in human semen (author's transl)].

In the present study, the androgen-binding properties of human semen was evaluated by experimenting with incubation and the technique for separating bound from unbound hormones. Some of the properties of a protein in human seminal plasma (SPABP) that has a high affinity and low capacity for binding dihydrotestosterone (DHT) was found and studied. The dissociation constant (Kd) was 1.63 X 10(-9) M and the number of binding sites of 275.3 X 10(-12)M was obtained. The intraassay and interassay coefficient of variation of this assay method was less than 5.6% and 8.4%, respectively. DHT was displaced from the binding protein by testosterone (81%), estradiol (75%) and levonorgestrel (63%). The endogenous level of steroids in human seminal plasma did not interfere with the estimation of DHT binding sites. In order to investigate the binding of DHT to human spermatozoa, the separation of sperm from the incubation mixture was accomplished by low-field centrifugation followed by 3,000 X G for 10 minutes. Using this separation method, the optimal steady-state condition for DHT-binding was found to be an incubation time of one hour. The binding of DHT to spermatozoa was nonspecific in nature, that is, of high capacity and low affinity (Kd greater than 10(-6)M).

Androgen-Binding Protein↗
PubMed1982

[Studies on the source of androgen binding protein (ABP) in human seminal plasma (author's transl)].

Androgen binding protein in human seminal plasma (SPABP) which has a high affinity-low capacity for dihydrotestosterone (DHT) was measured by saturation-charcoal adsorption technique. No correlation was found between SPABP binding capacity for DHT and sperm count or motility, but there was a significant correlation between SPABP binding capacity per ejaculate and semen volume. In order to determine the source of this binding protein seminal plasma from vasectomized men was analyzed, split ejaculates were studied from normal volunteers and SPABP was compared from epididymal ABP and from serum testosterone-estradiol binding (TeBG) by isoelectric analysis. There was no significant difference in SPABP binding capacity in semen from vasectomized (293.2 +/- 84.2pM) and non-vasectomized men with azoospermia (289.6 +/- 108.6pM). Analysis of split ejaculates showed the following: 1) the sperm density was significantly greater in the first fraction; 2) the concentration of fructose was greater in the second fraction; 3) SPABP binding capacity was the same in both fractions. The isoelectric analyses showed that SPABP was distinctly different from epididymal ABP and serum TeBG. In these data, this DHT-binding protein is not the same as testicular ABP. It appears to originate from both the prostate and seminal vesicles.

Androgen-Binding Protein↗