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Biomedical subjects

T Niijima

Publications and source records attributed to T Niijima.

At least 145 records · Page 8Linked to original sources
PubMed1983

Responses of serum testosterone levels to human chorionic gonadotrophin stimulation in patients with Klinefelter's syndrome after long-term androgen replacement therapy.

Responses of serum testosterone levels to repeated daily injections of 5000 IU hCG for 4 days were studied in 24 patients with Klinefelter's syndrome. Eighteen patients were untreated, and 8 had been given previous treatment with depot testosterone 100 mg intramuscularly every 2-3 weeks for an average duration of 4.7 years. Among them, 4 patients were examined both before and after the therapy. The hCG test was performed at least 2 weeks (0.5-12 months) after the last injection of depot testosterone in the treated patients. Mean basal testosterone level of the treated patients, 139 +/- 98 ng/dl (Mean +/- SD), was not significantly different from that of the untreated patients, 172 +/- 110 ng/dl. Maximum stimulated testosterone level in the treated patients, 170 +/- 107 ng/dl (P less than 0.05). These results suggest that long-term androgen administration may decrease the functional reserve of Leydig cells in patients with Klinefelter's syndrome.

Adolescent↗
PubMed1983

Carcinoma in situ of germ cells and subsequent development of an invasive seminoma in a hyperprolactinaemic man.

A 25-year-old man was first seen complaining of impotence and found to have a pituitary tumour and hyperprolactinaemia. Both testes were small and atrophic, but a testicular tumour was not apparent. Biopsy of the right testis was performed, and the pathology report described thickening of the seminiferous tubule walls and impaired spermatogenesis. The patient refused to undergo an operation for his pituitary tumour and was lost to follow-up. 5 years later, the same patient presented with enlargement of his right testis, and this and the pituitary tumour were excised. The testicular tumour was classified as seminoma, and the pituitary tumour as an adenoma with low malignancy. Re-examination of the previous specimen of his right testis revealed foci of carcinoma-in-situ. This is an additional example of the growth of an invasive germ cell tumour from non-invasive carcinoma-in-situ of the testis.

Adenoma↗
PubMed1983

Experimental urinary bladder reconstruction using a synthetic poly(alpha-amino acids) membrane.

Biodegradability of the poly(epsilon-benzyloxycarbonyl-L-lysine) membrane was tested for use as a biodegradable graft for the reconstruction of rabbit urinary bladder. Rabbit urinary bladder was exposed through a midline incision under general anesthesia and segmental resection with full thickness was done, with replacement by this synthetic membrane. The membrane was gradually reabsorbed, serving as a framework of support for regeneration of normal bladder tissues. Follow-up study at 1 year revealed no urinary tract complications, such as bladder stones or urinary tract infection. Also, no disturbance of renal function was demonstrated. Bladder capacity remained within normal limits and bladder functions were almost normal. These results indicate that biodegradable membrane may be well suited to this clinical use.

Animals↗
PubMed1983

[Double-blind comparative clinical study of cefpiramide (SM-1652) and cefsulodin on complicated urinary tract infections due to P. aeruginosa].

The therapeutic efficacy and safety of Cefpiramide (CPM, SM-1652) at a 2 g/day dose were objectively compared with those of Cefsulodin (CFS) at a 2 g/day dose in patients with chronic complicated urinary tract infections (UTI) by P. aeruginosa in a double-blind study at 46 institutions in Japan. The results are as follows: The therapeutic efficacy was analyzed in 254 patients (136 cases administered CPM and 118 cases administered CFS) after excluding 20 cases as drop-out. Among 254 cases, the number of patients with infection of P. aeruginosa was 190 cases (100 cases administered CPM and 90 cases administered CFS), while that with infection of organisms other than P. aeruginosa was 64 cases (36 cases administered CPM and 28 cases administered CFS). By the administration of a 2 g/day dose for 5 days, the overall clinical effective rate of CPM was significantly higher than that of CFS in total patients. When the patients were classified into 2 groups with respect to causative organisms (P. aeruginosa and others), the clinical effective rate of CPM in patients with infections of P. aeruginosa was significantly higher than that of CFS, while the clinical effective rate of CPM in patients with infection of other organisms than P. aeruginosa was the same as that of CFS. As to the bacteriological effect on bacteriuria, the eradication rate of CPM was significantly higher than that of CFS not only against all causative organisms but also against P. aeruginosa. The rate of replacement by S. faecalis was significantly higher in the CFS-treated group than in the CPM-treated group. The same result was obtained on the rate of replacement by other organisms. The MIC values of CPM for isolated organisms before drug administration were lower than those of CFS. The incidence rates of side effects and the abnormal findings of clinical laboratory tests were the same for the CPM- and CFS-treated groups. From the results, it was concluded that CPM is a useful drug for the treatment of patients with chronic complicated urinary tract infections caused by P. aeruginosa.

Adult↗
PubMed1983

[Ultrasonographic assessment of bladder tumors: clinical staging].

Staging of urinary bladder cancer is quite important since it is closely related to the prognosis of patients and also determines the mode of treatment. In the past, several techniques have been developedd for this purpose. Cystoscopy, bimanual examination, cystography and biopsy are useful for determines T categories of TNM classification and pelvic angiography also is utilizing, but these methods only provide indirect information on cancer infiltration and some of the methods require skill, especially pelvic angiography is rather complicated and accurate evaluation is difficult to obtain. We develope a new technique by transurethral intravesical ultrasonic scanning for preoperative staging of bladder cancer. The device uses a transurethrally intubated probe with a head that can be angled 90 degree against its long axis. Results of staging by this technique on 83 cases of bladder cancer were reported. Comparison of ultrasonic and pathological stages showed concordance in 59 of 61 removed by total or partial cystectomy (17 cases, with 30 tumors) and TUR (44 cases). At present time, this scanner was developed to obtain a real-time image. Diameter of probe sheath was reduced to 24 F. The resolution of the tomogram was improved by 7 MHz. ultrasound, which clearly displayed the ureteral penetration of the bladder wall. Outline of diagnostic criteria are as follows Ta, T 1: The normal thickness of the wall beneath the tumor T 2: The bladder wall is indented slightly at the tumor base T 3: marked thickening of the bladder wall and sonolucent mass occupies the whole thickness of the wall The pretreatment classification by the TNM system is commonly utilized throughout the world. Out ultrasonic technique will be one of the essential examination for clinical cancer staging of the bladder in years to come.

Humans↗
PubMed1983

Abnormalities of various serum enzyme activities in patients with congenital adrenal hyperplasia.

Recently, attentions are being aroused as to the enzymatic network abnormalities lying behind congenital enzyme deficiency syndromes. We investigated abnormalities in activities of various hydrolytic enzymes in serum of patients with congenital adrenal hyperplasia (CAH, 21-hydroxylase deficiency). Several enzyme activities including trypsin-like enzyme, cathepsin C and esterase were significantly decreased in patients' serum. Especially the esterase activity in patients' serum was reduced to one third of controls and this may have some relations to the abnormal steroid metabolism of these patients. A multivariate analysis showed unexpectedly extensive abnormalities in enzyme interrelationships. These results suggest that wide variety of abnormal metabolism may be related to an apparent enzyme deficiency.

Adolescent↗
PubMed1983

L-Isoleucine and L-leucine are promoters of bladder cancer in rats.

We developed a short term assay for screening promoters of bladder cancer. This assay, in which maintenance of concanavalin A-agglutination of isolated rat bladder cells induced by subcarcinogenic treatment with bladder carcinogen is measured, suggested the possible promoting effects of L-isoleucine, L-leucine, D-tryptophan, and L-valin. Long term in vivo carcinogenesis experiments were carried out on L-isoleucine and L-leucine and it was shown that both were, in fact, promoters of bladder cancer in rats.

Animals↗
PubMed1982

Nucleic acid metabolism of bladder carcinoma cells in vitro.

Nucleic acid metabolism was investigated to determine the metabolic activity of bladder carcinoma cells. Surgically obtained specimens were subjected to this investigation. Radio-active nucleic acid precursors, 14C-Formate via the de novo synthetic pathway, and 14C-Adenine via the salvage pathway, were used. Activities of bladder carcinoma cells were determined by their incorporation rates. The results were as follows: 14C-Formate incorporation was much higher in grade III bladder carcinoma cells than in the normal epithelium of the bladder; it was highest in stage B2 bladder carcinoma cells. 14C-Adenine was found to be incorporated into nucleic acid bases of bladder carcinoma cells. It was observed that as the grades and stages progressed, higher incorporation rates were observed. Comparison between the activities of de novo synthesis and salvage pathway was made. The latter was more active than the former in bladder carcinoma cells.

Adenine↗
PubMed1982

Investigation of genetic markers in a true hermaphrodite with chi 46,XX/46,XY.

We documented a new case of chi 46,XX/46,XY true hermaphroditism substantiated by the evaluation of chromosomal heteromorphism in banded preparations. The patient, a 12-year-old Japanese boy with ambiguous external genitalia, was seen because of abnormal breast development. Surgical exploration showed the right gonad to be an ovotestis and the left gonad to be an ovary. Cytogenetic studies revealed cell admixtures of 46,XX and 46,XY karyotypes in peripheral lymphocytes, skin fibroblasts, and gonadal fibroblasts. From the pedigree studies, the paternal double genetic contributions were evidenced by the differences of sex chromosomes and the blood group types for the ABO and MNSs systems in the two cell lines of the patient. The maternal double genetic contributions were confirmed by the inheritance of Q-fluorescent markers on chromosomes 13 and 22 and by alleles for the Kidd blood group system.

Blood Grouping and Crossmatching↗
PubMed1982

Increase of T lymphocytes bearing immunoglobulin G receptors during circulation in human renal cell carcinoma.

We studied the membrane markers and functions of lymphocytes from venous and arterial blood in kidneys from patients with renal cell carcinoma. The proportion of T lymphocytes that bore the receptors for the Fc portion of immunoglobulin G increased significantly in venous blood compared to arterial blood in kidneys with tumors. The assay of antibody-dependent cellular cytotoxicity demonstrated that lysis of target chicken erythrocytes was significantly less when caused by lymphocytes from the arterial blood (38 plus or minus 18 per cent, standard error) than those from the venous blood (54 plus or minus 21 per cent) in kidneys with tumors. There was no significant difference in the spontaneous lymphocyte-mediated cytotoxicity assay between the venous and arterial blood. Increment of the antibody-dependent cellular cytotoxicity activity seemed to correlate with the increased proportion and absolute number of T lymphocytes bearing immunoglobulin G.

Adenocarcinoma↗