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Biomedical subjects

T Nakada

Publications and source records attributed to T Nakada.

At least 577 records · Page 32Linked to original sources
PubMed1984

Increased adrenal epinephrine and norepinephrine in spontaneously hypertensive rats treated with hyperbaric oxygen.

Adrenal catecholamines were determined in Wistar Kyoto rats (WKY), and stroke-prone and stroke-resistant spontaneously hypertensive rats (SHRSP, SHR) treated with hyperbaric oxygen for 90 minutes daily from 6 to 13 weeks of age. The animals were divided into 5 groups. Group I (control group), was handled under the same conditions as pressure-treated groups II and III, but with ambient oxygen pressure and concentration. Group II (pressure-control group), was treated with 2 atmospheric absolute pressures (ATA) of air without any oxygen provided. Group III (high-oxygen group), was exposed to 2 ATA under the environment of air saturating oxygen. Group IV (antihypertensive group), was treated with hydralazine. Group V (adrenalectomized group), was given 1% NaCl solution and bilateral adrenalectomy. The average contents of adrenal norepinephrine of SHR and of SHRSP in Group I were greater (p less than 0.05-p less than 0.001) than those of the WKY in Group I. A similar tendency was also observed for the content of adrenal epinephrine. The average concentrations of adrenal epinephrine and norepinephrine of SHR and SHRSP in Group II and III were significantly (p less than 0.05-p less than 0.001) greater than those of the respective rats in Group I, but no significant differences were noted in the blood pressure between pressure-treated groups (II, III) and the control group (I). Adrenalectomized SHR, SHRSP and WKY rats (Group V) had similar blood pressure levels as the control rats (Group I). The development of hypertension in SHR and SHRSP was effectively suppressed by the treatment with hydralazine, which, however failed to reduce concentrations of adrenal epinephrine and norepinephrine in these rats. These results indicate that increased adrenomedullary function in SHR and SHRSP is further enhanced by hyperbaric oxygenation treatment, but that high concentrations of adrenal catecholamines are not required for the pathogenesis of spontaneous hypertension of these animals at this age.

Adrenal Glands↗
PubMed1984

Epileptic Kluver-Bucy syndrome: case report.

The Kluver-Bucy syndrome (KBS) consists of prominent oral tendencies, emotional blunting, altered dietary habits, hypersexuality, and visual and auditory agnosia. It was first produced experimentally in monkeys; subsequently, many human cases have been reported. The syndrome results from bilateral temporal lobe damage, and is mainly observed in conditions which tend to produce such damage, such as herpes encephalitis, Pick disease, and head injury. A case of KBS associated with psychomotor status epilepticus is reported.

Agnosia↗
PubMed1983

[Therapeutic experience of primary aldosteronism associated with chronic renal failure].

A 58-year-old man with primary aldosteronism associated with chronic chronic renal failure was treated with CAPD, oral administrations of Trilostane and furosemide. No adverse clinical or laboratory response could be attributed to these combination therapies. After subsequent removal of aldosterone-producing adenoma from left adrenal gland, his clinical symptoms were slightly improved. This case, still received CAPD treatment, is a unique presentation for primary aldosteronism without showing suppressed plasma renin activity.

Adrenal Gland Neoplasms↗
PubMed1983

Autosomal dominant motor system degeneration in a black family.

Autosomal dominant motor system degeneration has been described primarily in Portuguese families from the Azorean Islands. The symptoms include various combinations of ataxia, pyramidal and extrapyramidal signs, appendicular dystonias, tics, ophthalmoplegias, and peripheral neuropathies with amyotrophy. One non-Portuguese, non-Azorean black family has been described previously; this report describes a second such family affected by autosomal dominant motor system degeneration.

Adult↗
PubMed1983

Solitary metastasis of systemic malignant lymphoma to the cerebellopontine angle.

Systemic malignant lymphoma rarely produces solitary metastasis to the brain. We report such a case in the cerebellopontine (CP) angle mimicking an acoustic neurinoma. CT scan showed a large, round mass in the CP angle which enhanced homogeneously following contrast infusion. The internal auditory meatus appeared to be eroded. The clinical, radiological, and pathological findings are presented.

Cerebellar Neoplasms↗
PubMed1983

Coexistence of hyperplasia of renomedullary interstitial cells and juxtaglomerular cells after acute occlusion of renal artery.

A left renal artery aneurysm was found in a 45-year-old normotensive man. In an attempt to evade the possible occurrence of aneurysmal rupture, aneurysmectomy in addition to left renal biopsy (first surgery) was performed. This vascular operation led to a virtually complete renal artery stenosis concomitant with the development of hypertension. The renin-angiotensin-aldosterone system and levels of plasma prostaglandins were also increased following this failed surgery. Reconstruction of the affected renal artery was technically so difficult that left nephrectomy was carried out (second surgery). Renal specimens obtained at the first surgery revealed no histological abnormalities. Discriminating histological findings of the kidney obtained at the second surgery were remarkable; hyperplasia of the juxtaglomerular cells producing renin and hyperplasia of the renomedullary interstitial cells which had pecularities similar to cells known to secrete renal prostaglandins. High levels of the renin-angiotensin-aldosterone system and plasma prostaglandins after the first surgery were reduced following the second surgery. It is suggested that acute constriction of the renal artery led to a hyperplastic change of the juxtaglomerular cells and the renomedullary interstitial cells and stimulated an inappropriate release of renin and renal prostaglandins.

Acute Disease↗