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Biomedical subjects

T Nakada

Publications and source records attributed to T Nakada.

At least 541 records · Page 30Linked to original sources
PubMed1985

Buccofacial apraxia without aphasia due to a right parietal lesion.

Buccofacial praxis in right-handers is thought to be mediated by the left hemisphere. We present the case of a right-handed man without family history of sinistrality who exhibited a buccofacial apraxia following a unilateral right parietal infarction. Other findings such as intact language, visuospatial impairment, and hemi-inattention are more characteristic of right posterior lesions.

Apraxias↗
PubMed1985

Renal adenoma incidentally found in removed kidney in a patient with transitional cell carcinoma of the renal pelvis.

Concurrent primary renoparenchymal or renal pelvic neoplasms of different histology in the same kidney appear to be unusual. We herein report on a 75-year-old man in whom a tiny renal adenoma, a transitional cell carcinoma of the renal pelvis, ipsilateral ureter papillomas and transitional carcinoma of the urinary bladder were found. The clinicopathologic findings of this patient as well as the oncogenesis of renal tumours are discussed.

Adenoma↗
PubMed1985

Enhanced protein synthesis in the renal arteries of genetically hypertensive rats: its possible role in causing hypertension.

A study was made of the vascular protein synthesis in young, genetically hypertensive rats, mainly in their renal arteries. Some of the rats were treated either with 3.5 mg/kg of phenoxybenzamine (POB) or with 4 mg/kg of propranolol twice daily, from 6 to 8 weeks of age. 3H-proline was injected intravenously into each rat before sacrifice to analyse the in vivo incorporation rates of tritiated proline into the vascular collagen and vascular non-collagenous proteins. Evidence has been presented that: (1) the rates of incorporation of 3H-proline into collagen and non-collagenous proteins of the renal arteries in spontaneously hypertensive rats (SHR) and stroke-prone spontaneously hypertensive rats (SHRSP) were greater than those in normotensive Wistar Kyoto rats (WKY); (2) the administration of POB decreased incorporation of 3H-proline into the collagen and non-collagenous proteins of the renal arteries concomitant with a reduction of blood pressure in every rat strain; (3) the administration of propranolol failed to decrease the incorporation of 3H-proline into these connective tissue proteins in the renal arteries and this drug did not reduce blood pressure in every rat strain; (4) the incorporation rates of 3H-proline into these protein fractions in hearts were similar in every rat strain which received any drug treatment. These results indicate that an increased synthesis of collagen and non-collagenous proteins in the renal arteries of young SHR and SHRSP rats participates in the pathogenesis of spontaneous hypertension in the early hypertensive stage.

Animals↗
PubMed1985

Primary aldosteronism treated by trilostane (3 beta-hydroxysteroid dehydrogenase inhibitor).

The practicability and tolerability of trilostane, a competitive inhibitor of 3 beta-hydroxysteroid-delta 5-dehydrogenase, for the therapy of primary aldosteronism was assessed in 1 patient with aldosterone-producing adenoma (APA) and 3 subjects with idiopathic adrenal hyperplasia (IHA). Trilostane afforded reduction of plasma levels of aldosterone, progesterone, deoxycorticosterone, 17-OH progesterone, cortisol, delta 4-androstenedione, and urinary excretion of 17-hydroxycorticosteroid. Conversely, circulating levels of dehydroepiandrosterone, dehydroepiandrosterone sulfate, and urinary excretion of 17-ketosteroids were increased following this drug therapy. Suppression of mineralo- or glucocorticoid biosynthesis was accompanied by an increase in plasma renin activity. One patient with APA or 3 subjects with IHA showed slight or remarkable improvement of hypertension and hypokalemia. Based on these findings, efficacy and tolerability of trilostane appear to aid in the treatment of IHA.

17-Hydroxycorticosteroids↗
PubMed1985

Intravesical instillation of doxorubicin hydrochloride and its incorporation into bladder tumors.

We studied single dose intravesical doxorubicin instillation (50 mg. dissolved in 30 ml. saline) in 29 patients with bladder tumor and 2 with dysplasia of the bladder. The results demonstrated that 1) the levels of doxorubicin hydrochloride in extracts of tumors were significantly higher than those of histologically normal bladder tissues in all regions examined except the dome, 2) the incorporation concentration of the drug into the smallest tumor was 3-fold greater than that of larger tumors, 3) tissue concentration of the drug in histologically normal bladder tissues was 2.4-fold greater in patients with recurrent than with primary bladder tumors, and 4) a high concentration of the agent was noted in unifocal, multifocal and primary tumors classified as papillary noninvasive or invasive transitional cell carcinoma. These findings indicate that intravesical installation of doxorubicin hydrochloride can be incorporated to a high degree by relatively small papillary noninvasive or invasive transitional cell carcinoma located in almost all regions except the bladder dome.

Adult↗
PubMed1985

Subacute diencephalic necrosis and dural arteriovenous malformation.

We report a case of congestive venous necrosis involving the diencephalon symmetrically, presumably precipitated by a dural arteriovenous malformation (AVM). The patient presented with a 1-month history of intermittent confusion and gait ataxia. The initial radiological work-up revealed a dural AVM. The patient's subsequent deterioration was accompanied by computed tomographic findings of diencephalic congestion. Pathological examination showed subacute necrosis of the diencephalon. We discuss the pathogenesis of this case of subacute diencephalic necorsis and its possible relationship to the entity of subacute diencephalic angioencephalopathy.

Brain Diseases↗
PubMed1985

Experience with surgery for thymoma associated with pure red blood cell aplasia. Report of three cases.

We present three cases of thymoma associated with pure red blood cell aplasia in which thymomectomy and thymectomy were performed. Case 1, a patient with pure red blood cell aplasia and hypogammaglobulinemia, was treated after surgery with immunosuppressive agents. She did not show any remission and died eight months after the operation. Case 2, a patient with pure red blood cell aplasia alone, showed transient erythropoiesis only in the early post-operative period and died one year and seven months after the operation. Patient 3 had pure red blood cell aplasia alone before surgery and was treated after surgery with prednisolone and fluoxymesterone. He showed good remission from the aplasia after these treatments; however, myasthenia gravis appeared seven months after the operation. These results seem to show that such combined therapy as applied in case 3 may be effective for some of the patients with pure red blood cell aplasia and thymoma; however, the effects of thymomectomy or thymectomy (or both) are still controversial for the treatment of pure red blood cell aplasia.

Anemia, Aplastic↗
PubMed1985

Prognostic evaluation of tracheobronchial reconstruction for bronchogenic carcinoma.

Fifty-two patients have undergone tracheobronchial reconstruction for bronchogenic carcinomas over a 20 year period and have been evaluated from the view point of prognosis. Five-year survival rates of the patients undergoing reconstructive operations were as follows: 35% for the total group, 50% for those with squamous cell carcinoma, and 64% for those with Stage I and II disease. No patients with adenocarcinoma or Stage III disease have survived more than 5 years. However, the number of patients with early adenocarcinoma was too small for us to conclude that the histologic type per se affected survival. Six of eight patients with sleeve lobectomy and pulmonary artery reconstruction died within 2 years, 7 months postoperatively. Five of seven patients died within 1 year after carinal reconstruction. However, two are alive at 4 months and 2 years, 9 months after left or right sleeve pneumonectomy. In summary, any types of lobectomy or pneumonectomy with reconstruction of the tracheobronchial tree can be conducted in patients with Stage I and II lung cancer. Sleeve lobectomy with pulmonary artery reconstruction can be an alternative to pneumonectomy when pneumonectomy is contraindicated because of low cardiopulmonary reserve. In patients undergoing reconstruction of the carina, prophylactic radiation therapy may be necessary during the postoperative course.

Adenocarcinoma↗
PubMed1985

[Portosystemic A-V fistula and portal hypertension associated with islet-cell tumor of the pancreas].

A 50-year-old woman was admitted on Feb. 25, 1983, complaining of hematemesis and melena. Endoscopic examination revealed the rupture of the esophageal varices. At first she was treated with pressure hemostasis using a S-B tube, but it was failed. Then she underwent esophageal transection under emergency thoracotomy. After the operation, she developed ascites and watery diarrhea, though there was no episode of hematemesis and melena. A bruit was audible at the epigastric region. Abdominal angiograms demonstrated a fist-sized portosystemic A-V fistula (PAVF) locating at the pancreas head, and suggested concomitant existence of portal hypertension. On May 16, 1983, laparotomy was carried out in order to reduce portal pressure, but it was not successful. She died 3 weeks after the second operation. Autopsy and pathological findings revealed that PAVF associated with a hen-egg-sized islet-cell tumor of the pancreas head. Etiology and clinical features of this rare entity may be characterized by the nature of the islet-cell tumor having rich and rapidly growing vascular supply.

Adenoma, Islet Cell↗