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Biomedical subjects

T Muto

Publications and source records attributed to T Muto.

At least 595 records · Page 33Linked to original sources
PubMed1984

[Multiple duodenal carcinomas associated with multiple gastric cancers].

Because of the rarity of primary duodenal cancer, the coexistence of this disease with gastric cancer is very rare. The case presented herein suffered from two carcinomas of the duodenum and six gastric cancers. The patient was 71-year-old man who underwent subtotal gastrectomy and pancreatoduodenectomy. Pathologic studies showed that all of the gastric and one of the duodenal cancers were limited to the mucosal layer and that the other duodenal tumor invaded to the pancreas. Several cases of double cancers in the duodenum and the stomach have been reported in Japan, and this is first of multiple carcinomas of the duodenum associated with multiple gastric cancers.

Adenocarcinoma↗
PubMed1983

Morphogenesis of human colonic cancer.

A total of 155 early carcinomas, collected from colonoscopic polypectomy cases, surgically removed specimens, and resected colon from patients with adenomatosis coli, were histologically investigated in order to find their characteristic morphologic features. The commonest types of early carcinomas examined had a short stalk or were broad-based, and carcinomas 1 to 2 cm in diameter were the largest in actual number, although the malignancy rate increased with increasing size. The malignancy rate of small adenomas, under 1 cm in diameter, is higher than previously estimated. The clinical importance of the shape and size of such polyps is stressed for earlier detection of carcinomas of the colon, and an improved concept of the morphogenesis of colonic carcinoma is proposed.

Carcinoma↗
PubMed1983

Motility study in right sided diverticular disease of the colon.

Intraluminal pressure in the ascending colon of 13 patients with right sided diverticular disease and 10 of normal subjects was studied with catheter-tip transducer inserted through colonoscopes. In the resting state the colonic motility index of patients with diverticular disease was greater than that of the controls. After intravenous injection of neostigmine methylsulphate higher pressure waves were more frequently observed in patients with diverticular disease than the controls, and the colonic motility index of patients was much greater than that of the controls with statistical significance. From these observations it is suggested that high intraluminal pressure and the abnormal motility in the ascending colon plays an important role in the pathogenesis of right sided diverticular disease.

Adolescent↗
PubMed1983

An epizootic of pneumococcal infection occurred in inbred guinea pig colonies.

Epizootiological observations were made on an outbreak of pneumococcal infection occurred in 14 inbred guinea pig colonies during January to October, 1981. Monthly incidences of diseased animals ranged from 16.6 to 0%, showing the highest rate in the first month of the occurrence. Affection rates were remarkably different according to guinea pig strains, being 75% in JY-1 but 0% in JYG and Strain 2. Affected animals showed ruffled fur, dry-dirty noses, emaciated abdomen and dyspnea, and some of them were resulted in death. At necropsy, the fibrinopurulent pneumonia, pleuropneumonia and pleuritis were found as the major pathological features, and in addition, the fibrinopurulent pericarditis and peritonitis with a large amount of exudate were also observed in some cases. Streptococcus pneumoniae was isolated from nearly all the affected organs, and also from the external nares and trachea. Isolation rate from the external nares was especially high, thus 97.1% of infected guinea pigs including healthy carriers were detected by cultivation of nasal swab samples. Carrier rates of healthy animals were gradually increased from 17.2% in April to 36.5% in October, but the organism was not detected from JYG strain at all. During the observation period, vaccination, advance of weaning age of animals and administration of high vitamin C dose were taken as preventive measures of the epizootic, but no remarkable effect was obtained. The same diseased conditions were successfully produced in Hartley guinea pigs by experimental nasal infection of a pneumococcal strain isolated from this epizootic.

Animals↗
PubMed1983

Adenomatous intestinal hyperplasia in guinea pigs associated with Campylobacter-like bacteria.

Adenomatous intestinal hyperplasia was diagnosed in two dams and five young guinea pigs. The pathological condition was characterized by diarrhea and the thickened, rugose jejunum and ileum. Adenomatous proliferation of immature crypt epithelial cells was observed primarily in the ileum and the distal part of the jejunum. Immature epithelial cells contained various numbers of intracytoplasmic, non-membrane bound, curved organisms resembling Campylobacter sp. bacteria.

Adenoma↗
PubMed1983

[Clinical evaluation of neocarzinostatin in digestive system cancer. 1. Administration of neocarzinostatin in advanced and recurrent carcinoma of the stomach].

This study was designed to evaluate the most effective administration method of NCS for advanced carcinoma of the stomach, mainly nonresectable and/or recurrent cases which were collected by our cooperative study group. Nine hundred seventy six cases were available for clinical evaluation. Rate of the efficacy of NCS alone and combined with 5-FU was higher (P less than 0.1) in the cases administrated intravenously by drip infusion than in those by one shot injection method, and adverse effects were fewer in the former than in the latter cases. The rate of efficacy of NCS was higher in cases treated with 4,000 mu/day alone intermittently 2-3 times for a week than in those with 2,000 mu/day alone every day. The rate of clinical effect was higher in the cases treated with 4,000 mu of NCS combined with 50 mg of 5-FU intermittently than in those with 2,000 mu of NCS combined with 250 mg of 5-FU every day, especially 20.6% of the former cases given more than 50,000 mu of NCS were interpreted as clinically effective by Karnofsky's criteria of I-A over.

Antibiotics, Antineoplastic↗
PubMed1983

[Clinical evaluation of neocarzinostatin in digestive system cancer. 2. Clinical studies on the administration of neocarzinostatin in advanced and recurrent carcinoma of the pancreas].

The present study was designed to evaluate the efficacy of chemotherapy by NCS for advanced and/or recurrent carcinoma of the pancreas, mainly nonresectable cases in which exploratory laparotomy or construction of biliary fistula were performed. Three hundred fifty seven cases were available for the study. Of the 357 cases, 116 were treated with NCS alone 5-FU. In the former, the efficacy rate was higher in cases with 2,000 mu/body of NCS every day than in those with 4,000 mu/body of NCS intermittently 2-3 times for a week. 19.6% of the cases treated with more than 40,000 mu of NCS alone in total were interpreted as effective clinically by Karnofsky's criteria of I-A over. In the latter, the efficacy rate was higher in cases with 2,000 mu/body of NCS combined with 250 mg of 5-FU every day than in those with 4,000 mu of NCS combined with 500 mg of 5-FU intermittently, 22.5% of the cases given more than 40,000 mu of NCS in total were interpreted as effective clinically by Karnofsky's criteria of I-A over. The major adverse effects of NCS such as anorexia, vomiting and nausea were observed in 20% of total cases respectively, leucopenia in 10% and fever in 15% of them.

Antibiotics, Antineoplastic↗
PubMed1983

[Randomized study on the long-term adjuvant chemotherapy with ftorafur and mitomycin C for stomach cancer: second report].

In view of the usefulness of long-term adjuvant chemotherapy, the Cooperative Study Group of Surgical Adjuvant Chemotherapy for Gastric Cancer adopted as the second cooperative study a prospective randomized trial on three groups; MMC alone, Futraful alone and a combination of MMC and Futraful. In the group of Futraful alone the survival and disease-free rate were improved in three years after operation, especially marked in patients with the advanced stage. Moreover, the survival and disease-free rate in the group of the combination therapy were higher than those in the group of Futraful alone, and the relapse rate was lower in the former. Therefore, a long-term combined adjuvant chemotherapy with MMC and Futraful seems to be one of the most effective chemotherapy regimens for resectable advanced gastric cancer.

Drug Therapy, Combination↗
PubMed1982

Superficial spreading carcinoma of the esophagus.

Superficial spreading type of carcinoma of the esophagus was defined as lesions with intramucosal extension of carcinoma 20 mm or more from the main lesion. Eleven (6.1%) of 179 cases were thus selected for this investigation. These cases were further divided into two groups: Group A, consisting of four cases (2.2%) with the main lesion confined to the submucosa, representing a relatively early stage; and Group B, consisting of seven cases (3.9%) with the main lesion invading the muscular layer or deeper. One of the most characteristic features in the four cases belonging to Group A was an unexpectedly high incidence of lymphatic permeation and lymph node metastases leading to a poor prognosis. Another feature that may be important, particularly for surgeons performing esophagectomy, was the difficulty in deciding the proximal resection line of the esophagus because the boundaries between involved and uninvolved portions were frequently indistinguishable in this particular pathologic entity, not only in Group A but in Group B.

Aged↗
PubMed1982

Tumorigenicity of human BK papovavirus plaque isolates, wild-type and plaque morphology mutant, in hamsters.

The polyoncogenic prototype human papovavirus BKV (Gardner's strain) produced clear, small and large plaques. Two small-plaque isolates (wt-500 and wt-502), as well as a large-plaque-forming isolate (wt-501), induced frequent brain tumors and occasional osteosarcomas (but no insulinomas) in hamsters. The large-plaque former (wt 501) was more tumorigenic than the two small-plaque mutant (pm-525), which had been rescued from hamster tumor cell lines and have small deletion near the origin of DNA replication, induced frequent brain tumors and insulinomas. Mutant 522 was about five times more tumorigenic than wt-501. These results support the hypothesis that the polyoncogenicity of prototype BKV is accounted for by the presence of BKV mutants.

Adenoma, Islet Cell↗
PubMed1982

Simultaneous determination of chlorpromazine and levomepromazine in human plasma and urine by high-performance liquid chromatography using electrochemical detection.

A rapid, selective and sensitive method for the simultaneous determination of chlorpromazine and levomepromazine in human plasma and urine has been developed using high-performance liquid chromatography with electrochemical detection. The unchanged drugs and internal standard extracted from plasma and urine were separated by reversed-phase high-performance liquid chromatography. The influence of acetonitrile concentration and of the pH of the mobile phase were investigated. The detection limits were 100 pg for chlorpromazine and for levomepromazine. In comparison with three other detection systems this was found to be the most sensitive method. This method was successfully applied to the simultaneous determination of chlorpromazine and levomepromazine in human plasma and urine for pharmacokinetic studies.

Chlorpromazine↗