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Biomedical subjects

T Muto

Publications and source records attributed to T Muto.

At least 577 records · Page 32Linked to original sources
PubMed1985

[Randomized study of long-term adjuvant chemotherapy with Futraful and mitomycin C in gastric cancer. A second study (fourth report)].

In view of the usefulness of long-term adjuvant chemotherapy, the Cooperative Study Group of Surgical Adjuvant Chemotherapy for Gastric Cancer adopted as a second cooperative study a randomized controlled trial including three groups; MMC alone, Futraful alone and a combination of MMC and Futraful. In the groups given Futraful alone and the combination therapy, the survival and disease-free rate were improved at five years, in patients with stage III. Moreover, the survival and disease-free rate for the group given combination therapy were higher than those for the group given Futraful alone. Also, in the groups given Futraful alone and the combination therapy, toxicities probably due to the long-term Futraful therapy were minor, without serious side effects. Therefore, a long-term combined adjuvant chemotherapy with MMC and Futraful seems to be an effective chemotherapy regimen for resectable gastric cancer. A more potent regimen and cyclic therapy may be needed to improve the result of treatment.

Clinical Trials as Topic↗
PubMed1985

[Juxta-papillary duodenal diverticula in patients with primary common duct stones].

Incidence of juxta papillary duodenal diverticula (JPDD) was studied in 182 patients with benign biliary diseases. Incidences of JPDD were 11.1% in cholecystolithiasis, 23.4% in cholecystocholedocholithiasis and 54.5% in choledocholithiasis. Concerning to the patients with common duct stones, average of age was significantly higher in the group with diverticulum than in the group without diverticulum (65.9 +/- 7.6 vs 55.9 +/- 13.7, p less than 0.01). Diameter of the common duct was also significantly larger in the group with diverticulum. To exclude the effect of aging, the same comparison was performed in patients older than 60 years. Here again, the group with diverticulum showed significantly greater dilatation of the common duct. Incidences of JPDD in the primary and secondary common duct stones were 73.1% and 19.7%, respectively. The difference was highly significant. JPDD seemed to play an important role in the pathogenesis of cholestasis in the aged patients which may result in formation of primary common duct stones.

Adult↗
PubMed1985

[Surgical indication and outcome of Crohn's disease with special reference to management of anal lesions].

A total of 31 cases of Crohn's disease; 23 males and 8 females; 8 small bowel, 11 colon, 8 both small and large bowels involvement and 4 unknown, were collected and analysed. Twelve cases were treated medically and 19 were operated with 61% of operative and 37% of reoperative rate. There was no death due to Crohn's disease. IVH was successful as non-surgical treatment. Indications for surgery were stricture, fistula formation and unsuccessful medical treatment. Limited resection of the diseased segment was performed and in 4 cases diseased segment was left behind without significant postoperative symptoms. Quality of life of the surgically and medically treated patients was satisfactory except one who had many operations during 20 years and still suffers from Crohn's disease. In 15 (48.4%) periproctal abscess or fistula was associated. There were 2 types of anal lesions, the one being ordinary type of low intersphincteric abscess or fistula and the other complex or Crohn's disease related high abscess or fistula. The former was successfully treated by laying-open whereas the latter was treated rather conservatively by drainage not to damage external sphincter muscles. Outcome of medical and surgical treatment of Crohn's disease was quite satisfactory and operation should not be hesitated in patients with serious complications. Type of anal lesion is to be identified and proper surgical treatment should be performed in feasible cases.

Anal Canal↗
PubMed1984

Histopathologic comparison of colorectal adenomas in English and Japanese patients.

Histopathologic comparison of colorectal adenomas removed at St. Mark's Hospital, London, England, and those removed at the University of Tokyo, Japan was performed. There were 1242 lesions in the St. Mark's series and 310 in the University of Tokyo series. All adenomas were removed either by colonoscopic polypectomy or hot biopsy. The indications and methods of colonoscopic removal were similar in the two series. Age distribution of the patients showed a younger peak incidence in the University of Tokyo series compared with the St. Mark's patients. The percentage of adenomas larger than 1 cm, of tubulovillous or villous type, and with moderate or severe dysplasia were greater in the St. Mark's series than in the University of Tokyo series. Percentages of adenomas with mild, moderate, or severe dysplasia in each category of size did not differ between the two series. In view of the fact that there is a high colorectal cancer risk in England and medium cancer risk in Japan, our results give further epidemiologic support to the concept of the adenoma-carcinoma sequence.

Adenoma↗
PubMed1984

Diverticular disease of the colon in Japan. A review of 615 cases.

Of 615 patients with diverticular disease of the colon, 429 had diverticula in the cecum and ascending colon, 98 in the sigmoid and descending colon and 88 in both the right- and left-side colon. The right-sided type was more common in younger people and more predominant in men, whereas the left-sided type was more common in the elderly and showed no difference in numbers between men and women. More than 50 per cent of patients were asymptomatic and 25 per cent complained of disturbed bowel function. The frequency of diverticulitis was not related to location, but to the number of diverticula. Seventy-seven were complicated by acute inflammation (right-sided diverticulitis, 61, and left-sided diverticulitis, 16). Many patients with right-sided diverticulitis improved with medical treatment and the operative procedure of choice was drainage of the inflamed area with supplemental appendectomy.

Adult↗
PubMed1984

Ten years-long survey on pathogen status of mouse and rat breeding colonies.

Eleven pathogens including P. aeruginosa, Salmonella spp., E. coli O115a, c: K(B), P. pneumotropica, B. bronchiseptica, C. kutscheri, Tyzzer's organism, M. pulmonis, Sendai virus, MHV and Syphacia spp. were surveyed in 217 mouse and rat breeding colonies during 1972-1981. In conventional animals, P. pneumotropica and/or Syphacia spp. were detected in nearly 90% of 89 mouse and 64 rat colonies. Sendai virus, M. pulmonis, P. aeruginosa and MHV were positive in 51.7 to 23.6% of the colonies, and Tyzzer's organism, B. bronchiseptica and probably SDA virus were also detected in more than 10% of the rat colonies. Salmonella spp., E. coli O115a, c: K(B) and C. kutscheri were found in a few colonies. In SPF animals, P. aeruginosa was isolated from about one third of 33 mouse and 31 rat colonies, and P. aeruginosa was isolated from about one third of 33 mouse and 31 rat colonies, and P. pneumotropica was also positive in 3 rat colonies. Infection rates of P. pneumotropica, M. pulmonis, Sendai virus and Syphacia spp. were usually higher than 40% of animals sampled from colonies contaminated with them. Accidental contaminations of SPF colonies were usually caused by P. pneumotropica and Syphacia spp.

Animals↗
PubMed1984

[A randomized study on the long-term adjuvant chemotherapy with ftorafur and mitomycin C for gastric cancer: the second study (III)].

The Cooperative Study Group of Surgical Adjuvant Chemotherapy for Gastric Cancer adopted, as a second cooperative study, a prospective randomized trial on three groups: MMC alone, Ftorafur alone, and a combination of MMC and Ftorafur. The number of patients subjected to this analysis was 3033. The usefulness of long-term adjuvant chemotherapy was studied, based on a follow-up period of 4 years after surgery. No definite differences were observed in general. However, classified by prognostic factors, both the survival and disease free rates were improved in patients with stage III, n (+) ps (+) advanced cancer, to whom Ftorafur alone was administered for a long-term period. In patients who underwent of curative resection, the long-term administration of Ftorafur alone tended to prevent recurrence postoperatively, especially within the first two postoperative years. However the survival and disease free rates in the group receiving Ftorafur combined with MMC were higher than those of the group receiving Ftorafur alone. Moreover the combination of MMC and Ftorafur prolonged survival even in patients who did not undergo curative resection, and was found to be particularly useful in such patients, as designated by more than two prognostic factors.

Clinical Trials as Topic↗