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Biomedical subjects

T Morimoto

Publications and source records attributed to T Morimoto.

At least 667 records · Page 37Linked to original sources
PubMed1986

[Ependymal cyst--case report].

An eleven-month-old male infant with an ependymal cyst is reported. He was born after full-term pregnancy and vacuum extraction. His growth and development was somewhat retarded and he could control his head at the age of five months. He was admitted to our hospital because of the enlargement of his head and the paretic right upper limb. On admission he was found to be a well-nourished infant with the head circumference of 54.5 cm and the height of 75.5 cm. Physical examination disclosed slight weakness in the right upper extremity but no signs of increased intracranial pressure. Computed tomography (CT) revealed a huge low density area in the left frontoparietooccipital region which extended to the right across the midline. Another low density area was seen in the quadrigeminal cistern. CT findings also suggested an association with agenesis of the corpus callosum. The huge supratentorial cyst was isolated from the ventricles and subarachnoid space, which was shown by administration of metrizamide into the cyst. Carotid angiograms showed displacement of both anterior cerebral arteries to the right, which were dissociated from each other. This fact and an association with agenesis of the corpus callosum supported the idea that the cyst originiated in the interhemispheric fissure and expanded into both hemispheres. Cyst fluid was watery clear and protein and sugar contents were 13 mg/dl and 56 mg/dl respectively. The patient underwent a left frontal craniotomy and partial removal of the cyst wall was performed to make a communication with the ventricle. His postoperative course was uneventful and the weakness of the right upper extremity gradually improved.(ABSTRACT TRUNCATED AT 250 WORDS)

Agenesis of Corpus Callosum↗
PubMed1986

[Carotid-ophthalmic aneurysms and visual abnormalities].

The direct neck clipping for carotid-ophthalmic aneurysm is hazardous and difficult as compared with other intracranial aneurysms because of its location adjacent to the anterior clinoid process, the optic nerve, and the cavernous sinus. The authors discuss the visual abnormalities accompanied by carotid-ophthalmic aneurysm on the basis of our experiences with 30 patients with 33 aneurysms. Ten patients (4 of 14 with ruptured aneurysms, 6 of 16 intact aneurysms) had preoperative visual abnormalities. Of our series of patients, visual acuity and visual field were impaired in one eye. The most common field abnormalities were unilateral inner or upper side defects. In the patients whose aneurysms were intact, visual abnormalities had been slowly progressive over many months. Otherwise, 2 cases with ruptured aneurysm experienced their first visual symptoms at the same time their hemorrhage. According to the projection of aneurysm with respect to internal carotid artery, superomedial and posteromedial projections were common in the patients with visual abnormalities. Seven patients with visual dysfunctions were operated on. Improvement of the visual symptoms was observed in 3 cases. In these cases, complete collapse of the aneurysm with good decompression of the optic nerve was obtained at operation. Two patients deteriorated following surgery; this occurred in relation to attempts to clip the aneurysm neck directly, and optic nerve was probably excessively manipulated. Two patients had no change in visual symptom: one was treated with trapping of internal carotid artery combined with STA-MCA anastomosis, another had direct hemorrhage into the ipsilateral optic nerve.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1985

Involvement of nipple and areola in early breast cancer.

In 141 mastectomy specimens, performed for invasive or noninvasive carcinomas, histopathologic study was performed to assess the extent of nipple-areola involvement by the tumor. In this study, patients were excluded if the tumor was located beneath the areola; and nipple and/or areola abnormalities were clinically present. Tumor involvement of the nipple and/or areola was found in 44 of 141 specimens (31%), with intraductal growth in 36 (82%) of 44, stromal invasion in 3 (7%), and ductal and stromal invasion in 5 (11%). Analysis of nipple-areolar involvement with consideration of the different variables indicates that it occurred in association with tumor size, tumor-areola distance, and histologic type. Such information provides clinically relevant guidelines in decision making for limited breast surgery.

Adenocarcinoma, Mucinous↗
PubMed1985

Changes in coenzyme Q level in mitochondria of cirrhotic rat liver.

In the cirrhotic rat liver induced by carbon tetrachloride and phenobarbitone, the concentrations of mitochondrial Coenzyme Q were measured in comparison with other respiratory components. The concentration of cytochrome a(+a3) and Coenzyme Q significantly increased in the cirrhotic liver, without any changes in the ratio of Coenzyme Q to cytochrome a(+a3). It is suggested that such increase of Coenzyme Q plays an important role as one of the adaptive responses to compensate for the prolonged metabolic overload on the mitochondrial respiratory assembly. Also, from the findings that the concentrations of cytochrome a(+a3) in the mitochondria of cirrhotic liver increase concomitant with the severity of cirrhosis, it is suggested that the rise of Coenzyme Q levels may be one of the indicators for the decreased functional reserve capacity in liver cirrhosis.

Animals↗
PubMed1985

AN6520 Ag: an antigen purified from liver with non-A, non-B hepatitis.

An extract prepared from the liver of patient with chronic non-A, non-B (NANB) hepatitis was found to produce a precipitin line in immunodiffusion with a serum from a multiply transfused patient and those from patients convalescent from NANB hepatitis. The antigen was purified by gel filtration and density gradient centrifugation. The antigen had a buoyant density of 1.16-1.20 g/cm3 in cesium chloride, a sedimentation coefficient (S20,w) of 51.5, and a molecular weight of larger than 1.5 X 10(6) daltons. Electron microscopic examination revealed particles 29-34 nm in diameter (average 31.5 nm), which could be agglutinated by the specific antiserum. We developed a reverse passive hemagglutination (R-PHA) and a passive hemagglutination (PHA) technique for detection of the new antigen and antibody, respectively, and applied these to human sera. Antibody to the antigen was detected in 19/28 (67.9%) convalescent sera of NANB hepatitis. This prevalence was significantly higher than those found in convalescent sera of type A hepatitis patients (2/17 = 11.8%), type B hepatitis patients (2/15 = 13.3%), and normal blood donors (9/129 = 7.0%) (p less than 0.01); and the prevalence in hepatitis A and B patients did not differ significantly from that of normal donors. Furthermore, most (66.7%) of the cases of NANB hepatitis endemic in Shimizu City, Japan, showed clear seroconversion with respect to this antibody. These results suggest that the new antigen/antibody system is associated with NANB hepatitis.

Adult↗
PubMed1985

Total pelvic exenteration for advanced carcinoma of the lower colon.

Thirteen patients with advanced carcinoma of the lower colon and no evidence of extrapelvic metastasis were submitted to total pelvic exenteration. Nine of the 13 patients had ureteral urinary diversion by the ileal segment conduit. Three had colonic conduit bladder using the terminal portion of the descending colon. One patient had bilateral uretero colonic anastomosis. The operative mortality rate was 7.7%. Determinate 5-year survival rate of 38.5% was achieved. Histological examinations of the surgical specimen revealed associated abscesses adjacent to the tumor in six cases, although the cancer extended to the bowel wall and adhered to the surrounding structures in all specimens. Total pelvic exenteration assures a better quality of life, lessening of symptoms, disease control and, in selected patients, a cure.

Adenocarcinoma↗
PubMed1985

Diagnosis and operation for locally recurrent rectal cancer.

Local recurrence of rectal cancer following abdominoperineal resection is rarely amenable to limited resection. Six patients with deeply invading recurrent lesions had pelvic exenteration combined with sacral resection. This procedure seems a reasonable treatment for palliation and the chance of cure in selected patients. In order to select good candidates for this extensive procedure, carcinoembryonic antigen (CEA) assays and the diagnosis of locally recurrent tumor with pelvic computed tomography (CT) were evaluated. CEA assay is valuable for diagnosing most recurrent rectal cancers, but it is inadequate for early detection. A high CEA level often indicates extrapelvic tumor spread. CT examination is very valuable for the early detection and localization of recurrence in relation to pelvic structures.

Adenocarcinoma↗
PubMed1985

Characteristics of rhythmic jaw movements of the rabbit.

The jaw-movement pattern of the rabbit during chewing foods of different consistency was analysed. The basic movement trajectory on the frontal plane showed a crescent loop, irrespective of the food type. Difference in food consistency exerted only minor effects on the maximum gape, extent of lateral excursion and the chewing rate. These parameters of jaw movement and also the duration of a single masticatory cycle (TCL) appeared to change with physical properties other than the hardness of food. On the other hand, the number of chewing cycles in a masticatory sequence increased with increasing the hardness of food. The TCL ranged between 250 and 300 ms (frequency: 3.3-4 Hz). When a single masticatory cycle was divided into three phases (opening, closing and power phases), the TCL depended more on the duration of the opening phase than that of other two phases.

Animal Feed↗
PubMed1985

Use of the anaerobic threshold for evaluating various total artificial heart control algorithms in calves.

In the total artificial heart (TAH) project, choosing the best control mode is an important factor in the design of a completely implantable TAH. Four different control modes for the TAH were evaluated in the same calf using the anaerobic threshold (AT) as an assessment of aerobic capacity, where AT was defined as the oxygen consumption (VO2) at which the relationship between blood lactate measurements and VO2 became nonlinear during progressive treadmill exercise. This new approach tests the integrated response of the central, peripheral, and metabolic regulatory mechanisms to physiological workloads. Preliminary data showed AT in the left master alternatively ejecting mode to be slightly higher than in the other three modes.

Anaerobiosis↗
PubMed1985

Osmotic factors in restitution from thermal dehydration in rats.

The degree of voluntary dehydration after thermal dehydration was assessed while supplying drinking water of varying NaCl concentrations. Adult male albino rats were exposed to a hot-dry environment (dry bulb temp 36 degrees C; relative humidity 20%) for 6-8 h, and dehydration of 7% body wt was induced. After dehydration the rats were divided into three groups, and distilled water and 0.45 or 0.9% NaCl solution was given ad libitum. The amount of fluid intake reached an equilibrium in 6-12 h; the 0.45 and 0.9% NaCl groups regained almost all lost water, whereas the distilled water group regained only half. During rehydration the 0.45 and 0.9% NaCl groups gained Na by approximately 430-650 mueq and lost K by 90-130 mueq, whereas the distilled water group lost Na slightly and K by 80 mueq/100 g body wt. As for the electrolyte balance during thermal dehydration, rats excreted Na and K into urine and saliva. Na loss was 200 mueq/100 g, almost all of which was derived from the interstitial space of skin and skeletal muscle, and K loss was 230 mueq/100 g, almost all of which was derived from intracellular space of skeletal muscle. Total cation loss (Na, K) during thermal dehydration, including K excretion during rehydration, was 510-560 mueq/100 g, which was almost identical to the Na gained by rats given 0.45 or 0.9% NaCl solution. These results suggest that voluntary dehydration is caused by the dilutional inhibition of drinking due to loss of electrolytes during thermal dehydration.

Animals↗
PubMed1985

Intracerebroventricular injection of 125I-salmon calcitonin in rats: fate, anorexia and hypocalcemia.

Intracerebroventricular (i.c.v.) injection of 19 pmol/rat or more of salmon calcitonin (sCT) or iodinated sCT suppressed spontaneous intake of food and water in a dose-dependent manner. Tail-whipping was a peculiar behavior which concomitantly developed, but no analgesia ensued from the doses tested (up to 62 pmol/rat). It was examined how the rise and fall pattern of these behavioral effects would correlate with the dispositional pattern of 125I-sCT. When the radioactive peptide was injected in anorectic doses via the i.c.v. route, the radioactivity was found to distribute throughout the brain, but not uniformly. In rats which showed a marked anorexia and tail-whipping behavior, distribution occurred in such a manner that it could be interpreted to reflect the regional and subcellular distribution pattern of sCT-specific binding sites. Even 3 hr after injection, the hypothalamus, the smallest region, retained the highest radioactivity corresponding to about 1% of the dose and at least one half of which was identified as the intact iodo-sCT. To be noted is the finding that sCT injected centrally will quickly enter the systemic circulation and peripherally induced long-lasting hypocalcemia, since the anorectic dose of sCT is considerably higher than the dose needed for the peripheral effect. It is concluded that most of the sCT after i.c.v. injection leaks into the systemic circulation, but the rest is retained rather selectively around the receptor in hypothalamic nuclei for a long time, leading to day-long suppression of feeding and drinking behavior.

Animals↗
PubMed1985

Continuous measurement of fluid mobilization from ICF space following acute dehydration by dialyzation in dogs.

The changes of the distribution of body fluid following acute isotonic dialyzation were studied from the results of continuous monitoring of extracellular fluid volume and physiological parameters. An indicator of extracellular space, 51Cr-EDTA, was injected into splenonephrectomized dogs. After the equilibrium of tracer dilution was attained, 10 ml/kg of plasma water was isotonically withdrawn by means of a dialyzer of hollow fiber type. The volumes of extracellular fluid (ECF) and plasma (PV) were continuously monitored for 80 min and plasma osmolality was measured at 10 min intervals. At the 50-60th min after the fluid modification, the reduction of PV was only 3.8 ml/kg and that of ECF was 4.2 ml/kg. The continuous profile of ECF change showed a significant mobilization of water from intracellular fluid (ICF) soon after the dialyzation. It is concluded that, in the state of hypovolemia, plasma fluid is replenished with the transvascular fluid absorption from interstitial space and that, concomitantly, the reduction of ISF is restituted with the fluid mobilization from ICF into extracellular space within the early stage of 1 hr. Good linear correlation was found between the amount of mobilized water from ICF and the increment of plasma osmolality. An increase in osmotic force was considered the mechanism which caused the fluid shift. These findings suggest that the change in plasma osmolality is a good predictor of mobilized volume from ICF in hypovolemia. The effects of inverse fluid modification, i.e., isotonic infusion, were also compared.

Animals↗