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Biomedical subjects

T Misaki

Publications and source records attributed to T Misaki.

At least 289 records · Page 16Linked to original sources
PubMed1984

Photoradiation therapy of bladder tumours.

Photoradiation therapy (PRT), in which hematoporphyrin derivative (HpD) is activated by an argon-dye laser, was used on 46 superficial bladder tumours in 9 patients. It was suggested that there is little or no thermal cell killing effect of laser irradiation from study of the heating effect of the beam intensity. A fluorospectrophotometric study of biopsies from these tumorus and normal mucosa revealed preferential HpD localization in the malignant tissues. In tumours less than 1 cm diameter treated with 150 mwatts per cm2 for 5 minutes there were 2 CR and 5 NC, whereas with 200 mwatts per cm2 or more for the same time there were 15 CR and 5 PR. Concerning the accumulated energy intensity of the light, in tumours 1 cm in size or less, treatment with 100-250 joules per cm2 obtained CR in 5 of 6 tumours. From these results, it was suggested that the light intensity should be 300 mwatts per cm2 for 5-10 minutes or more and the total light dose should be 100 joules per cm2 or more in tumours up to 2 cm in size. There was no CR in tumours more than 2 cm in size. No early side effects were seen from the administration of HpD. Sensitivity to sunlight was seen in 4 cases.

Aged↗
PubMed1984

A trial manufacture of a motor-driven laser light scattering optic for whole bladder wall irradiation.

The detection of CIS of the bladder by fluorescence endoscopy with hematoporphyrin derivative (HpD) and argon ion laser was performed using a video monitoring system coupling with an image intensifier; however, it was difficult because of the reflecting light of the excitation light. Whole bladder wall photoradiation therapy was carried out in 3 patients with multicentric CIS of the bladder, using argon-dye laser light (630 +/- 1.6 nm) of 5 to 25 J/cm2. The anticancer effect of this therapy was followed by urinary cytology and clusters of vacuolated cancer cells were observed for 2 days after the therapy.

Carcinoma in Situ↗
PubMed1984

Photoradiation therapy of bladder tumors.

Photoradiation therapy (PRT), in which hematoporphyrin derivative (HpD) is activated by an argon-dye laser, was performed on 46 superficial bladder tumors in 9 patients. It was suggested there is little or no thermal cell killing effect of laser irradiation from a study of the heating effect of the beam intensity. A fluorospectrophotometric study of biopsies from tumors and normal mucosa revealed preferential HpD localization in malignant tissues. In tumors less than 1 cm in diameter treated with 150 mwatts per cm2 for 5 minutes there were 2 with complete remission (CR) and 5 with no change (NC), whereas with 200 mwatts per cm2 or more for the same time there were 15 CR and 5 with partial remission (PR). Concerning the accumulated energy intensity of light, in tumors 1 cm in size or less, treatment with 100-250 joules per cm2 obtained CR in 5 of 6 tumors. From these results, it was suggested that the light intensity should be 300 mwatts per cm2 for 5-10 minutes or more and the total light dose should be 100 joules per cm2 or more in tumors up to 2 cm in size. There was no CR in tumors more than 2 cm in size. No early side effects were seen from administration of HpD. Sensitivity to sunlight was seen in 4 cases.

Cystoscopy↗
PubMed1984

[Experience in percutaneous nephrostomy].

Percutaneous nephrostomy using the Seldinger technique was performed on 15 kidneys in 15 patients with obstructive hydronephrosis. A real-time ultrasound unit was used for needle guidance. Puncture was successful in the first attempt in 11 of the 15 cases (73.3%), and two or more repeated punctures were necessary in only 4 cases (26.7%). Subsequent catheter placement was feasible in each of the kidneys without any serious complications. This procedure proved to be safe, precise and highly useful in the management of the supravesical urinary obstruction by various diseases. Techniques, indications, results and complications of percutaneous nephrostomy are discussed.

Adult↗
PubMed1984

[A study on non-sterile intermittent self-catheterization for voiding dysfunction following radical uterine or rectal carcinoma surgery].

To determine the effectiveness of non-sterile intermittent self-catheterization, a study was made of 35 patients who had radical surgery of the carcinoma of the uterus or rectum between January, 1978 and October, 1982. These cases were divided into 2 groups; (1) early instituted group of 27 patients who used self-catheterization within 3 months following surgical intervention; (2) late instituted group of 8 patients who received drug treatment for more than 3 months after surgical treatments and then used self-catheterization. After the introduction of self-catheterization, urinary tract infection was evaluated on the basis of the incidence of pyuria defined as more than 5 white blood cells per high magnification field. In 16 of the 35 patients, the incidence of pyuria ranged from 0 to 20 per cent. Regarding prognostic results in the first group the application of self-catheterization, 6 patients had a residual urine ratio ranging from 0 to 20 per cent and were able to void at will. Uroflometry was performed in 9 patients in the first group. In 8 of these patients, UP max values increased 3 months after self-catheterization as compared with those before self-catheterization although their values were still lower than normal. Non-sterile intermittent self-catheterization can shorten the stay in hospital and enable the patient to live a catheter-free life.

Adult↗
PubMed1984

[A successfully treated case of Wolff-Parkinson-White syndrome with Ebstein's anomaly complicated with protein-losing gastroenteropathy].

A 17-year-old male underwent the division of the double accessory pathways under the diagnosis of Wolff-Parkinson-White (WPW) syndrome. At this time, we perceived that Ebstein's anomaly was combined with WPW syndrome, but we didn't treat Ebstein's anomaly, because it was slight. After this operation he relieved from the tachycardia attack completely. Ten months later, he was re-admitted to our hospital because of cardiomegaly and systemic edema. Hypoproteinemia was pointed out. On the basis of the intracardiac catheterization and 131I-RISA test, it was made to be sure that hypoproteinemia was caused by the protein-losing gastroenteropathy due to the tricuspid valve regurgitation of Ebstein's anomaly. After the tricuspid valve replacement with Hancock valve, protein-losing into the gastrointestinal tract disappeared. The aggravation of the tricuspid regurgitation was unrelated to the division of the accessory pathways, and was caused by the natural course of Ebstein's anomaly.

Adolescent↗
PubMed1984

Successful surgical ablation of reentrant ventricular tachycardia caused by myocardial fibroma.

We successfully removed a fibroma of the left ventricle in a 13-year-old boy. The tumor had caused recurrent ventricular tachycardia, which was resistant to antiarrhythmic drugs. Preoperative and intraoperative electrophysiological studies led to a diagnosis of reentrant ventricular tachycardia. After surgical excision of the tumor, the ventricular tachycardia stopped completely and until now, 1 year after the operation, no antiarrhythmic drugs have been required.

Adolescent↗
PubMed1984

Phase analysis in the Wolff-Parkinson-White syndrome with surgically proven accessory conduction pathways: concise communication.

Twenty-one patients with the Wolff-Parkinson-White (WPW) syndrome who underwent surgical division of the accessory conduction pathway (ACP) were studied by gated blood-pool scintigraphy. In each case, a functional image of the phase was generated, based on the fundamental frequency of the Fourier transform. The location of the ACP was confirmed by electrophysiologic study, epicardial mapping, and surgery. Phase analysis identified the side of preexcitation correctly in 16 out of 20 patients with WPW syndrome with a delta wave. All patients with right-cardiac type (N = 9) had initial contraction in the right ventricle (RV). In patients with left-cardiac type (N = 10), six had initial movement in the left ventricle (LV); but in the other four the ACPs in the anterior or lateral wall of the left ventricle (LV) could not be detected. In patients with multiple ACPs (N = 2), one right-cardiac type had initial contraction in the RV, while in the other (with an intermittent WPW syndrome) the ACP was not detected. These observations indicate that abnormal wall motion is associated with the conduction anomalies of the WPW syndrome. We conclude that phase analysis can correctly identify the side of initial contraction in the WPW syndrome before and after surgery. However, as a method of pre-operative study, it seems difficult to determine the precise site of the ACP by phase analysis alone.

Adolescent↗
PubMed1983

Photoradiation therapy of bladder tumors.

Photoradiation therapy, in which hematoporphyrin derivative is activated by an argon-dye laser, was performed on 46 superficial bladder tumors in 9 patients. A fluorospectrophotometric study of biopsies from these tumors and normal mucosa revealed preferential hematoporphyrin derivative localization in malignant tissues. The tumor response was confirmed ultrasonographically in 36 stages Ta to Tl tumors. Treatment with 100 to 250 J./cm.2 obtained complete remission in 5 of 6 patients with tumors 1 cm. in size or less. For those with tumors up to 2 cm. in size the light intensity should be 300 mw./cm.2 for 5 to 10 minutes or more and the accumulated energy intensity of light dose should be 100 J./cm.2 or more. No patient with tumors more than 2 cm. in size had a complete remission.

Carcinoma, Transitional Cell↗
PubMed1983

Longterm effects of cryosurgery in the sheep heart.

This study concerns the longterm effects of both epicardial and endocardial cryosurgery with particular reference to the coronary arteries. Sheep were subjected to epicardial cryosurgery without cardiopulmonary bypass, and to endocardial application with bypass. In both groups the heart was kept beating throughout the operation. Neither cardioplegia nor aortic cross-clamping was used. In the first group applications were made for 5 min directly over or adjacent to a major branch of the left coronary artery. In the second, the cryoprobe was applied for 5 min or until atrioventricular dissociation occurred. No sheep developed late arrhythmias or evidence of myocardial ischaemia. Only minimal arterial changes were observed and all the major coronary arteries remained widely patent. Cryothermia to the heart produced a small discrete lesion without complication. Bright fluorescence of necrotic myocytes was observed in all the immature lesions when sections stained with haematoxylin and eosin were examined under ultraviolet light. This vivid fluorescence clearly delineated the extent of the lesions and persisted while cytoplasmic elements remained. Our results indicate that cryosurgery provides a safe and permanent technique for the surgical treatment of arrhythmias in man, and may safely be used even in proximity to the coronary arteries. Cardioplegia is contraindicated.

Animals↗
PubMed1983

Thyroid CT number and its relationship to iodine concentration.

Sixty-seven patients with thyroid disease and 24 normal controls were examined with computed tomography (CT). The mean CT number (Hounsfield units +/- SD) in the normal controls (118.1 +/- 12.2) was significantly higher (p less than 0.001) than the mean CT number in patients with diseased thyroids, except for 2 cases of simple goiter (CT numbers 113, 132). The mean CT numbers in the patients with Graves disease (69.5 +/- 17.6) and Hashimoto thyroiditis (61.4 +/- 9.1) were significantly higher than those in patients with adenoma (41.7 +/- 10.6, p less than 0.001), cyst (33.1 +/- 14.8, p less than 0.001), or cancer (48.7 +/- 13.0, p less than 0.01). In 14 patients studied, a significant correlation was observed between thyroid CT numbers and the iodine concentration of the tissue (r = 0.889; p less than 0.001).

Adolescent↗