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Biomedical subjects

T Manabe

Publications and source records attributed to T Manabe.

At least 505 records · Page 28Linked to original sources
PubMed1984

Regional lymph node involvement in benign renal angiomyolipoma.

A case of angiomyolipoma of the kidney with the involvement of regional lymph nodes and adjacent adipose tissue is reported. Histology of the tumor was essentially benign in either location. During three years of follow-up period, no recurrence or distant metastasis has appeared. It was considered that the tumor was benign and that the regional lymph node involvement probably represents a multicentric hamartomatous or choristomatous growth. In such an example, it is suggested that additional treatment such as radiation or chemotherapy should be avoided until a definitive evidence of distant metastasis is obtained.

Adult↗
PubMed1982

Evaluation of postoperative exocrine pancreatic function using chymotrypsin labile peptide.

The assessment of exocrine pancreatic function by the oral administration of a chymotrypsin labile peptide N-benzoyl-L-tyrosyl-p-aminobenzoic acid (BT-PABA) has proved to be an easy and reliable test of exocrine pancreatic function. It has the additional advantage that it can be used to study exocrine pancreatic function in all operative cases, even after gastrointestinal reconstruction. The recovery of p-aminobenzoic acid (PABA) correlates significantly with parameters of the PZ/CCK secretin (PS) test. Following Billroth II gastrectomy, the recovery of PABA decreased to 39.8 +/- 3.2% two weeks after and to 45.4 +/- 4.5% one to two months after operation, significantly lower than the 80.6 +/- 3.4% in normal subjects. In cases of cancer of the head of the pancreas, the exocrine function was 44.0 +/- 3.7%, and decreased to 17.5 +/- 3.0% after total pancreatectomy. Thus, BT-PABA enables a pertinent evaluation of pancreatic function in postoperative patients with various types of gastrointestinal reconstruction and also in cases when the PS test cannot be feasibly used.

4-Aminobenzoic Acid↗
PubMed1982

Separation of extremely acidic proteins, S-100 proteins and calmodulin, in some bovine tissues and mammalian brains by two-dimensional electrophoresis in the absence of denaturing agents.

Extremely acidic proteins in bovine brain extracts, including S-100 proteins and calmodulin, were separated by two-dimensional electrophoresis in the absence of denaturing agents. The pattern was compared with the patterns of other bovine tissue extracts and also with those of brain extracts of other species. S-100 proteins (S-100 a and S-100 b) were specifically abundant in nerve tissues. A small amount of S-100 proteins was detected in heart extract. Extracts of liver and kidney did not have S-100 proteins, but each showed the distribution pattern of acidic proteins characteristic to the tissue. Calmodulin seemed to be present in all tissue extracts examined. Comparisons of the patterns of acidic proteins in brain extracts of various animal species suggest that S-100 proteins are more "variable" in structure than calmodulin.

Animals↗
PubMed1982

Dirofilarial infection in human lungs.

Two cases of dirofilarial infection in the human being were reported. Dirofilarial infection is common in dogs but rather rare in human. A review of Japanese literature disclosed 13 cases of human dirofilarial infection. Scarcity of symptoms and its morphological similarity to tuberculosis or infarction as well as the popularity in pets suggest that the true incidence of infection may actually be higher than the above figure. Our cases alert us for the recognition of human dirofilarial infection, and careful examination of multiple sections in granulomatous or nonspecific infarcted lesions is suggested.

Dirofilariasis↗
PubMed1982

Tubular myelin figures in the lung with Wilson-mikity syndrome.

An electron microscopic examination of the lung from a patient with Wilson-Mikity syndrome revealed abundant tubular myelin in the atelectatic areas. The tubular myelin was seen free and adjacent to secreted lamellar bodies in the alveolar spaces as well as within macrophages, but never in type II cells. The transverse dimension of the tubular units ranged from 24 to 30 nm, and the distance between two tubules was 5-6 nm. Occasionally the center of a tubule contained a single electron dense particle. The structure of the tubular myelin presented here differs to some degree from that in rat lungs. To our knowledge, the presence of tubular myelin figures has not been reported in cases of Wilson-Mikity syndrome. Their relation to the etiology of the disease is totally unknown; however, our findings that they were present only in the area of atelectasis but not in emphysematous areas may be significant. An accumulation of similar cases with ultrastructural study and combined biochemical and physiological studies is awaited to permit some interpretation.

Biological Products↗
PubMed1982

[Surgery and drug therapy of advanced pancreatic cancer].

By applying an en bloc resection of the pancreas with adjacent soft tissue, regional lymph nodes and pertinent vascular structures, a better prognosis could be made for patients with stages I or II carcinoma of the pancreas. The patients with stages III or IV of carcinoma of the pancreas could only be treated to a certain degree of effectiveness by using systemic combination chemotherapy with a very limited prognosis. Recent development of slow releasing anticancer agents would give more positive aspect for the management of persistent pains due to carcinoma of the pancreas with the absence of systemic side effect.

Adult↗