Biomedical subjects
T Manabe
Publications and source records attributed to T Manabe.
[Changes in plasma secretin and gastrin levels in experimental obstructive jaundice].
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[Effect of gastrin-releasing peptide on the pancreas. I. Stimulatory mechanism of pancreatic exocrine secretion].
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A secured technique for pancreatojejunal anastomosis in pancreaticoduodenectomy.
In order to avoid complications after pancreaticoduodenectomy, a simple and safe technique for pancreatojejunal anastomosis was developed. After resection of the pancreas, a vinyl chloride tube with a circumferential knot is inserted into the pancreatic duct and tied with a Dexon suture. Pancreatojejunal anastomosis is performed by approximating the seromuscular layer of the jejunum around the opening to the parenchymal tissue of the pancreas with interrupted nylon sutures, eliminating the need for direct anastomosis between the duct and jejunum. The knot on the tube prevents the tube from dislodging, and pancreatic juice is completely drained until the tube is safely removed two to three weeks after the operation.
[Factors deciding survival rate after resection of pancreatic neoplasms. 4). Invasion of the neoplasms into the portal system].
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[Effect of gastrin-releasing peptide on pancreas. II. Effects of GRP on pancreatic, intestinal, gastric and femoral arterial blood flow].
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[Intraoperative radiotherapy of cancer of the pancreas].
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Effects of in vitro and in vivo ethanol and acetaldehyde on exocrine pancreatic secretion.
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Single stranded DNA binding antibodies in patients with obstructive jaundice.
An elevation of single stranded (ss) DNA binding antibodies was present in patients with biliary tract stones and/or tumor of the biliary tract or of the pancreas. The incidence of the appearance of ssDNA binding antibodies was 22 percent in cases of non-obstructive jaundice and 50 percent in those with obstructive jaundice. The incidence was particularly high (70 percent) in patients with obstructive jaundice of over 50 days duration. No significant correlation was seen between the levels of ssDNA binding antibodies and the serum total bilirubin. However, a significant correlation was observed between the levels of ssDNA binding antibodies and the serum IgM.
Human chorionic gonadotropin in normal, inflammatory, and carcinomatous gastric tissue.
Tissues from 12 patients with gastric ulcers, 50 patients with gastric carcinoma, and 2 normal subjects who died suddenly were examined immunohistochemically with antiserum against the beta-subunit of human chorionic gonadotropin. Human chorionic gonadotropin-beta-immunoreactive cells were present in the neck portion of the pyloric and pseudopyloric glands of normal and inflammatory gastric tissue. Gastric cancers located in the antrum-pylorus and the cardia were frequently associated with human chorionic gonadotropin immunoreactivity. These findings indicate that human chorionic gonadotropin-producing cells normally exist in the gastric mucosa, especially in the pylorus. It is speculated that normal human chorionic gonadotropin-producing cells may give rise to cancer in certain cases.
Malignant melanoma and extramammary Paget's disease in the same patient.
Axillary Paget's disease was found in a 34-year-old man who died of metastatic malignant melanoma. The primary cutaneous malignant melanoma was diagnosed 6 years before the patient's demise and was confirmed by the presence of melanin, a positive dopa reaction, and immunohistochemical demonstration of S-100 protein in neoplastic cells. Postmortem examination revealed Paget's disease of the axillary skin in addition to widespread metastases of malignant melanoma. Paget cells were positive for periodic acid-Schiff reaction and alcian blue. They were also immunohistochemically positive for carcinoembryonic antigen, but were negative for S-100 protein. This association of malignant melanoma and Paget's disease in the same person has not, to the best of our knowledge, been described before.
[Differential diagnosis of hepatocellular carcinoma by angiography].
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[Clinical experience of latamoxef in the field of neurosurgery on the penetration into the cerebrospinal fluid in the patients with postoperative meningitis].
Latamoxef (LMOX) at a dose of 2 g was intravenously administered to 12 cases with postoperative meningitis and the concentrations in serum and cerebrospinal fluid (CSF) were examined up to 2 hours and the results obtained were as follows; The average serum and CSF concentrations of LMOX were 125.0 micrograms/ml, 4.33 micrograms/ml at 0.5 hour, 80.7 micrograms/ml, 4.64 micrograms/ml at 1 hour and 45.8 micrograms/ml, 3.82 micrograms/ml at 2 hours, respectively. The clinical responses of LMOX against postoperative meningitis were revealed excellent in 4 cases and good in 8 cases. No side effects were observed. LMOX was thought to be effective agent in the treatment of the postoperative meningitis.
IgA containing circulating immune complexes and IgA anti-single stranded DNA antibodies in patients with obstructive jaundice.
Elevated levels of IgA containing circulating immune complexes (IgA-CIC) and IgG containing (IgG-) CIC were detected in patients with obstructive jaundice due to biliary tract stones and/or tumour of biliary tract or pancreas. Levels of serum IgA were also elevated, and correlated with the levels of IgA-CIC. The levels of IgA and IgG anti-single stranded (ss) DNA were elevated, and there was a significant correlation between the levels of IgA-CIC and IgA anti-ssDNA antibodies. The cause of IgA-CIC increase in patients with obstructive jaundice might be due not only to simple obstruction of biliary tract but also to other factors such as a tissue destruction.
[Multidisciplinary treatment of cancer of the pancreas].
During the past 18 and a half years, 285 patients with cancer of the pancreas have been treated in our hospital. By means of en-bloc resection of the lesion with the portal vein and/or hepatic artery, the resectable rate of cancer of the head of the pancreas was improved to 53% (1979-1983) from 22% (1966-1978). Postoperative deaths within 30 days after pancreatectomy were 9.8%. The five years survival rate in those with Stage I and II was 28.7%, but that with Stage III and IV was 15.2%. Intraoperative and/or external radiation therapy was adopted on 16 patients, in some of whom hyperthermia was further combined. As a result, remarkable effects on performance status were obtained. Intra-arterial infusion chemotherapy using a transfemorally implanted catheter was performed on ten patients with unresectable lesions, the median survival of whom was however, only four and a half months.
[Case report of nonsecretory multiple myeloma with acute onset of renal failure and nodular glomerulosclerosis].
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[An appraisal of the surgical management of stage I and II cancers of the pancreas].
During the period between 1966 and 1984, 65 patients with duct cell cancer of the head of the pancreas underwent pancreatectomy. Among the 15 cases with tumors less than 2 cm in size, 27% were in stage I, 53% in stage II and 20% in stages III and IV, suggesting that small pancreatic cancer is not compatible with early cancer. Prognosis of cancer of the pancreas was mainly dominated by the stage of the cancer and radicality of the operation. The 5-year survival rate in patients with curative resection in stages I and II was 60%, and prognosis was particularly satisfactory in cases with no, So, Rpo and Vo. In cases of tubular adenocarcinoma of the pancreas, the prognosis was also influenced by the lymphatic, venous, perineural and connective tissue infiltrations. These results substantiate the concept that extended radical pancreatectomy is an indispensable procedure for cancer of the pancreas even in stages I and II.
An electroblotting apparatus for multiple replica technique and identification of human serum proteins on micro two-dimensional gels.
A new apparatus for electrophoretic transfer of proteins from micro polyacrylamide slab gels has been developed. The apparatus enabled the easy changing of nitrocellulose sheets and was suited for obtaining multiple blots from a gel. Electrophoretic conditions were determined so that all of the blots obtained sequentially from one slab gel were successfully used to visualize specific proteins irrespective of their molecular weight. Combining the transfer technique with the technique of parallel micro two-dimensional electrophoresis, 20 blots could be obtained within 1 h of electroblotting time. The locations of 28 human serum proteins were determined simultaneously on these blots using commercial specific antisera.