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Biomedical subjects

T Lundeberg

Publications and source records attributed to T Lundeberg.

At least 217 records · Page 12Linked to original sources

Acupuncture and sensory thresholds.

The effect of acupuncture on sensory thresholds was studied in 6 healthy subjects. The modes of acupuncture studied were: 1. manual stimulation, 2. electrical stimulation at 2 Hz, 3. electrical stimulation at 80 Hz. Superfiscial-acupuncture was used as placebo. Insertions of needles or application of electrodes were bilateral, at St 7 (intrasegmental) or Li 4 (extrasegmental). The study showed that manual or electro-acupuncture were effective when used intrasegmentally, raising pain threshold values 1.1 to 1.4 times that prior to stimulation. The pain threshold elevation obtained was not significantly related to plasma levels of beta-endorphin, ACTH or prolactin. Other sensory thresholds, thermal, vibrotactile and electrotactile were unaffected by such conditioned stimulation. Superfiscial-acupuncture had no significant effect on the sensory thresholds tested.

Acupuncture Analgesia↗

Vibratory stimulation as a treatment alternative in patients with tinnitus.

We evaluated the effect of vibratory stimulation on 10 patients with tinnitus and controlled it in a double-blind crossover trial against the sound stimulus delivered by the same apparatus. Five patients reported decreased intensity of tinnitus during treatment when vibratory stimulation was used, as opposed to 1 patient who reported decreased intensity of tinnitus when only the sound stimulus was used. There were no significant differences between the groups in the reduction of the unpleasantness associated with tinnitus. No longterm effects of treatment were seen.

Adult↗

Effect of electrical nerve stimulation on healing of ischaemic skin flaps.

Blood circulation was measured by laser doppler flowmetry in fasciocutaneous flaps of 24 patients who underwent reconstructive surgery for mammary carcinoma. 19 of the 24 patients had clinical signs of deficient circulation in the flaps. 14 patients were treated with electrical nerve stimulation (ENS) and 10 with placebo-ENS. Varying degrees of necrosis developed in 8 of the 10 patients who received placebo stimulation but in none of those treated with ENS. In the 5 patients with good capillary refilling and no signs of stasis or oedema before treatment, only minor increases in blood flow occurred after ENS.

Adult↗

Calcitonin gene-related peptide (CGRP) and transcutaneous electrical nerve stimulation (TENS) increase cutaneous blood flow in a musculocutaneous flap in the rat.

The effect of blood flow on transcutaneous electrical nerve stimulation (TENS) and injection of calcitonin gene-related peptide (CGRP) was studied in a musculocutaneous flap of the rat, using laser Doppler flowmetry. The circulatory border was estimated before and after treatment. It was shown that repeated treatments with TENS gradually increased the blood flow, moving the circulatory border distally more than 100% after three treatments. Injection of NaCl into the dorsal central vein of the flap resulted in no increase in blood flow, whereas CGRP 10(-10) M increased the blood flow, so that the circulatory border moved distally 70% and 60%, respectively.

Animals↗

Transcutaneous electrical nerve stimulation (TENS) increases survival of ischaemic musculocutaneous flaps.

The effect of transcutaneous electrical nerve stimulation (TENS) on the survival of a dorsal musculocutaneous flap was studied in the rat. Postoperative TENS treatment significantly increased the flap survival area in groups of rats receiving different modes of TENS. The flap survival area was up to 95% in the TENS-treated groups compared with 33-45% in the control groups. Repeated (3 days) high intensity (20 mA), high-frequency (80 Hz) TENS applied segmentally at the base of the flap was shown to be the most effective treatment in increasing the flap survival. Preoperative TENS did not increase flap survival area compared with untreated controls. It is concluded that postoperative TENS treatment markedly increases the experimental flap survival area and may be of clinical value for treatment of local ischaemia.

Animals↗

Low power laser irradiation does not affect the generation of signals in a sensory receptor.

The effect of low power Helium-Neon (He-Ne) and Gallium-Arsenide (Ga-As) laser on the slowly adapting crustacean stretch receptor was studied. The results showed that low power laser irradiation did not affect the membrane potential of the stretch receptor. These results are discussed in relation to the use of low power laser irradiation on the skin overlaying acupuncture points in treatment of pain syndrome.

Acupuncture Therapy↗

Acupuncture for the alleviation of tinnitus.

The present study describes the effect of acupuncture in 12 patients with tinnitus. The patients were referred from the Department of Audiology, Karolinska Hospital, where their hearing and tinnitus were assessed. None of the patients had benefited from previous treatment for tinnitus. The selection of acupuncture points depended on the individual and was, to a limited extent, based on traditional Chinese medicine (TCM). Local points such as Si 19, Sj 17, and Sj 21 were fairly standard; distal points took into account associated problems of the patient, but were also points recommended in TCM for tinnitus. Ten treatments were attempted within a 6- to 12-week period. The treatments were carried out weekly or biweekly depending on the availability of patient and acupuncturist. Six patients had transient effects and noise reduction. However, no positive long-term results were obtained. Similarities between the experience of tinnitus and of pain are discussed in light of these findings.

Acupuncture Therapy↗

Effect of low power laser irradiation on nociceptive cells in Hirudo medicinalis.

The effect of low power Helium-Neon (He-Ne) and Gallium-Arsenide (Ga-As) laser on the nociceptors in Hirudo medicinalis was studied. The results show that low power laser irradiation does not: affect the membrane potential or the excitability of the nociceptive neurons, affect the mechanical pressure required to activate the nociceptors or their action potentials. The results indicate that the analgesic effects reported in humans with "laser-acupuncture" with similar modes of low power laser are likely not explained by effects on nervous tissue.

Action Potentials↗

A comparative study of continuous ultrasound, placebo ultrasound and rest in epicondylalgia.

In this study the pain alleviating effects of continuous ultrasound treatment in epicondylalgia has been compared to placebo ultrasound and to rest. Of 99 patients 33 were randomly allocated to receive continuous ultrasound treatment, 33 to placebo ultrasound treatment and 33 were recommended only rest. The 66 patients treated were each given 10 treatments over 5 to 6 weeks. The condition was significantly improved in the group treated with continuous ultrasound in 36%, in 30% given placebo, and in 24% of those recommended rest. A significant improvement was noted when the effect of continuous ultrasound was compared with rest, but continuous ultrasound treatment was not significantly better than placebo ultrasound.

Adult↗

Effect of vibratory stimulation on experimental and clinical pain.

The effect of vibratory stimulation on experimental pain of the skin overlying the right and left extensor carpi radialis longus muscle induced by electrical stimulation was studied in 16 healthy subjects and in 18 patients suffering from chronic epicondylalgia of the right elbow. In the healthy subjects there were no side differences whereas in the patients, the skin pain threshold over the painful right muscle was lower than that on the left unaffected side under resting conditions. After vibratory stimulation, the skin pain threshold increased bilaterally by 1.1-1.6 times the pre-stimulation threshold in the healthy subjects and by 1.2-2.3 times this threshold in the patients. In 8 of the healthy subjects there was an increase in peripheral blood flow during stimulation and in 8 there was a small decrease. In 13 patients the change in pain threshold was seen in phase with the local increase and peripheral decrease in peripheral blood flow. In all individuals, the pain thresholds were regained within 45 min of cessation of stimulation. This was in contrast to the general subjective pain in the patients; 12 patients reported that the relief of pain lasted for a period of 1-7 hours.

Adult↗

Is acupuncture sufficient as the sole analgesic in oral surgery?

Twenty-six patients who were undergoing operative removal of an impacted third molar were given acupuncture as an alternative to conventional local analgesia. Pain ratings during different stages of the surgical procedure showed that gingival and periosteal incisions were tolerated, with only minor pain experienced by 18 of the patients. During mucoperiosteal flap dissection 12 patients experienced unacceptable pain. In total, only 2 of the patients tolerated the entire procedure; however, they reported severe pain during the final part of the operation. In conclusion, it seems that acupuncture as performed in the present study could not subserve as a routine method for analgesia in this type of operative procedure.

Acupuncture Therapy↗

Effect of acupuncture on experimentally induced itch.

The effect of acupuncture on experimentally induced itch was studied in 10 healthy volunteers. Itching was induced by intradermal injections of histamine on the upper arm. 'Placebo-acupuncture', acupuncture and electro-acupuncture at 2 Hz or 80 Hz were applied over the injection site, proximal to the injection site (in the same dermatome) or extrasegmentally (ipsilateral to the injected arm) for a period of 5 min following induction of itch. In addition, the effect of a 5 min period and a 20 min period of stimulation of the skin area prior to the induction of itch were studied. The same periods of stimulation were also applied to extrasegmental points prior to the induction of itch on the arm. Acupuncture and 2 Hz and 80 Hz electro-acupuncture significantly reduced subjective itch intensity when applied intrasegmentally. No significant effects were obtained when stimulation was applied extrasegmentally. The results suggest that acupuncture or electro-acupuncture could be tried in clinical conditions associated with pruritus.

Acupuncture Therapy↗

Vibratory stimulation compared to placebo in alleviation of pain.

The placebo effect of vibratory stimulation was studied in 72 patients with chronic pain syndromes in a double-blind crossover trial using a vibrator and a "placebo unit". Pain alleviation was reported by 48% of the patients during vibratory stimulation compared with 34% for placebo treatment; statistical significance (p less than 0.005).

Adult↗

Effect of laser versus placebo in tennis elbow.

The purposes of this study were to compare the pain alleviating effects of laser treatment and placebo in tennis elbow. Also, the effects of laser radiation on the radial sensory nerve conduction, and the temperature changes in the tissue surrounding the treated radial nerve were studied. The results show that laser treatment is not significantly better than placebo in treating tennis elbow. Furthermore, no significant change was noted in the evoked sensory potential as well as subcutaneous temperatures in either experimental or control groups as a result of the applications of the laser radiation treatment.

Adult↗