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Biomedical subjects

T Lundeberg

Publications and source records attributed to T Lundeberg.

229 records · Page 13Linked to original sources
PubMed1985

Relief of pain from a phantom limb by peripheral stimulation.

In the present study, 24 patients suffering pain from a phantom limb were given vibratory stimulation or placebo as a pain-relieving measure. During stimulation, a reduction in pain was reported by 75% of the patients as compared to 44% during placebo. Depending on the phantom sensation, the best pain-reducing site was found to be either the area of pain or the antagonistic muscle. In 90% of the patients the best pain-reducing effect was obtained when stimulation was applied with moderate pressure over a large area. The results of the present study suggest that vibratory stimulation may be a valuable symptomatic treatment measure in patients suffering pain from a phantom limb.

Adult↗
PubMed1985

Naloxone does not reverse the pain-reducing effect of vibratory stimulation.

Fifteen patients suffering from chronic epicondylitis pain who obtained alleviation of pain with vibratory stimulation were studied to investigate the possible role of endogenous opioids in the mediation of pain alleviation of vibratory stimulation. The patients' subjective pain intensity was rated using a graphic rating scale. In five patients the changes in peripheral blood flow before, during and after vibratory stimulation were also studied. After 30 min of mechanical vibratory stimulation at 100 Hz, patients were given a double-blind intravenous injection of naloxone or saline (placebo). Twelve patients did not experience reversal of pain relief from naloxone (0.4 mg). Reversal of the pain alleviation induced by vibratory stimulation was seen in two patients after i.v. injections of naloxone and in one patient after i.v. injections of naloxone or saline. When an i.m. injection of naloxone 0.01 mg/kg was administered before and during vibratory stimulation, none of the patients experienced an antagonistic effect of the pain-reducing effect of vibratory stimulation. The results suggest that the pain relief obtained with vibratory stimulation at 100 Hz is not associated with release of endogenous opioids.

Adult↗
PubMed1985

Relief of primary dysmenorrhea by transcutaneous electrical nerve stimulation.

In this study we describe the use of high-frequency transcutaneous electrical nerve stimulation (TENS) (100 Hz) and low-frequency TENS (lf-TENS) (2 Hz trains) as compared with placebo-TENS (p-TENS) in a group of 21 patients suffering from primary dysmenorrhea. Naloxone, a relatively pure opiate antagonist, was an additional test administered to 6 volunteer patients who had experienced an alleviation of pain with TENS. As will be seen, 14 out of 21 patients receiving high-frequency TENS (hf-TENS) experienced a pain reduction exceeding 50% of its original intensity. During lf-TENS or p-TENS, only 7 and 5 patients, respectively, obtained pain relief exceeding 50%. In 4 out of 6 volunteer patients, the relief of pain obtained with lf-TENS was counteracted by naloxone, whereas the relief experienced with hf-TENS in the same patients was, in general, unaffected by naloxone.

Adolescent↗
PubMed1984

The pain suppressive effect of vibratory stimulation and transcutaneous electrical nerve stimulation (TENS) as compared to aspirin.

The pain reducing effect of vibratory stimulation and transcutaneous electrical nerve stimulation (TENS) as compared to aspirin and placebo was studied in 60 patients suffering myofascial or musculoskeletal pain. Vibratory stimulation at 20 Hz, 100 Hz and 200 Hz and two modes of TENS were used for peripheral stimulation. In 48 patients these modes of stimulation produced pain reduction. Out of these patients 29 rated vibratory stimulation or TENS as more effective than aspirin while 9 patients rated aspirin as more effective. Ten patients rated the pain suppressive effect of vibratory stimulation and TENS as being equal to that of aspirin. Six of the patients who experienced pain reduction with peripheral stimulation reported an effect only for one particular type of peripheral stimulation. The present results provide evidence that vibratory stimulation and TENS are as efficient and in some patients more efficient pain suppressive measures as compared to aspirin. It is suggested on the basis of these findings that vibratory stimulation and TENS merit consideration in the choice of treatment of myofascial or musculoskeletal pain.

Aspirin↗
PubMed1984

Long-term results of vibratory stimulation as a pain relieving measure for chronic pain.

In the present study 267 patients with chronic neurogenic or musculoskeletal pain were given vibratory stimulation for the pain. The patients were observed for 18 months or until they terminated the treatment. About half of the successfully relieved patients (59% of the total number of patients) reported more than 50% pain relief, as scored on a visual analogue and an adjectival scale. Seventy-two per cent of these patients reported an increased social activity and greater than 50% reduced intake of analgesic drugs after 12 months of home treatment. It is suggested that vibration may be a valuable measure for symptomatic treatment of chronic pain.

Adolescent↗
PubMed1984

Pain alleviation by vibratory stimulation.

In the present study 366 patients suffering acute or chronic musculoskeletal pain of different origin were given vibratory stimulation for the pain. Many of the patients had previously had treatments of various kinds without satisfactory relief. The effect of vibratory stimulation was assessed during and after stimulation using a graphic rating scale. Sixty-nine per cent of the patients reported a reduction of pain during vibratory stimulation. The best pain reducing site was found to be either the area of pain, the affected muscle or tendon, the antagonistic muscle or a trigger point outside the painful area. In most patients the best pain reducing effect was obtained when the vibratory stimulation was applied with moderate pressure. To obtain a maximal duration of pain relief the stimulation had to be applied for about 25-45 min.

Adolescent↗
PubMed1984

Vibratory stimulation for the alleviation of pain.

In the present study 66 patients suffering from chronic myalgia were given vibratory stimulation as a pain relieving measure. Several of these patients had previously undergone treatments of various kinds without any significant relief. Forty-one patients reported a significant (20%) reduction of pain during vibratory stimulation. The best pain reducing site was found to be either the area of pain, a trigger or acupuncture point outside the painful area. The best pain reducing effect was obtained when the vibratory stimulation was applied with moderate pressure (1.0 kg) over the underlying structures. To obtain a maximal duration of pain relief the stimulation had to be applied for about 30 minutes.

Adult↗
PubMed1984

A comparative study of the pain alleviating effect of vibratory stimulation, transcutaneous electrical nerve stimulation, electroacupuncture and placebo.

The pain reducing effect of vibratory stimulation at 100 Hz, transcutaneous electrical nerve stimulation (TENS) at 100 Hz, electroacupuncture at 2 Hz as compared to placebo was studied in 36 patients suffering from myalgia. In 29 patients these modes of stimulation produced pain reduction. Out of these patients 18 rated vibratory stimulation, TENS or electroacupuncture as more effective than placebo while 6 patients rated placebo as more effective. Five patients rated the pain suppressive effect of vibratory stimulation, TENS and electroacupuncture as being equal to that of placebo. Four of the patients who experienced pain reduction with peripheral stimulation reported an effect only for one particular type of peripheral stimulation. The present results provide evidence that vibratory stimulation, TENS and electroacupuncture are as efficient pain suppressive measures and superior to placebo. It is suggested on the basis of these findings that vibratory stimulation, TENS and electroacupuncture merit consideration in the choice of treatment of myalgia.

Acupuncture Therapy↗
PubMedDate not supplied

Effects of electro-acupuncture on corticotropin-releasing factor in rats with experimentally-induced polycystic ovaries.

The aims of the present study were to investigate corticotropin-releasing factor (CRF) concentrations in the brain, the adrenal glands, and the ovaries in rats with estradiol valerate (EV) induced polycystic ovaries (PCO). The effect of 12 electro-acupuncture (EA) treatments on CRF concentrations was also investigated. The CRF concentrations in the median eminence (ME) were significantly increased in rats with PCO (both the PCO control group and the PCO group receiving EA) compared with the healthy control group (veichle control group), indicating increased activity in the hypothalamus-pituitary axis. The CRF concentrations in the ovaries were significantly reduced in the PCO group receiving EA compared with the PCO control group. Also, there was a decrease in comparison withthe healthy control group but the decrease was not as significant. This finding indicates that repeated EA treatments change the neuroendocrinological state in the ovaries, which may play an important role in reproductive failure.

Adrenal Glands↗
PubMedDate not supplied

Nerve growth factor release by human synovial fibroblasts prior to and following exposure to tumor necrosis factor-alpha, interleukin-1 beta and cholecystokinin-8: the possible role of NGF in the inflammatory response.

OBJECTIVE: Aim of this study was to investigate the synthesis, release and effects of nerve growth factor (NGF) in human synovial cells isolated from synovial tissue specimen from healthy and osteoarthritis (OA) patients. METHODS: Human synovial fibroblasts cultures were established starting from healthy and osteoarthritis patients. NGF protein levels in the culture medium, NGFmRNA and high-affinity NGF receptor (Tyrosine kinase A: TrkA) expression in the cells were evaluated in basal conditions and after stimulation with pro-inflammatory cytokines or with the neuropeptide cholecystokinin-8 (CCK-8). The effect of NGF supplement to culture medium on cell proliferation, TrkA expression, and tumour necrosis factor-alpha (TNF-alpha) and inducible-nitric oxide synthase (iNOS) production was investigated. RESULTS: Under basal conditions human synovial cells produce and release NGF. Both interleukin-1-beta (IL-1 beta) and TNF-alpha, but not CCK-8 promote NGF synthesis and release from OA cells. TrkA NGF receptors are also expressed in both normal and OA synovial cells. NGF, but not IL-1 beta, TNF-alpha and CCK-8, enhances the expression of TrkA in isolated synovial cells. NGF down-regulates IL-1 beta-induced TNF-alpha and iNOS production by OA synovial fibroblasts. CONCLUSIONS: NGF is produced and released and TrkA receptors are expressed in synovial inflammation. Overexpression of NGF in inflammed joints might be involved in the modulation rather than in the induction of the joint inflammatory response.

Cells, Cultured↗