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Biomedical subjects

T Lundeberg

Publications and source records attributed to T Lundeberg.

At least 199 records · Page 11Linked to original sources
PubMed1991

Concentration of substance P, neurokinin A, calcitonin gene-related peptide, neuropeptide Y and vasoactive intestinal polypeptide in synovial fluid from knee joints in patients suffering from rheumatoid arthritis.

We have studied the presence of five neuropeptides in knee joint synovial fluid from either patients suffering from rheumatoid arthritis and pain (n = 18) or being subjected to arthroscopy due to meniscal/cruciate ligament injuries (n = 13). Radioimmunoassay technique was used for peptide analysis using antisera SP2 against substance P (SP), K12 against neurokinin A (NKA), CGRPR8 against calcitonin gene-related peptide (CGRP), NPY1 against neuropeptide Y (NPY) and VIP2 against vasoactive intestinal polypeptide (VIP). No SP could be detected, and lower levels of NKA was found in arthritic joints vs controls. CGRP and NPY was found in higher concentrations in arthritic patients vs controls. VIP was found sporadically in both arthritis and control patients. Our data show some quantitative differences between patients suffering rheumatoid arthritis and pain, and patients with non-inflamed joints without pain; indicating an involvement of peptidergic fibers in arthritis in humans.

Adult↗
PubMed1991

A placebo controlled trial of ultrasound therapy in chronic leg ulceration.

A controlled study of the effects of ultrasound on healing chronic leg ulcers was carried out in conjunction with standard treatment on 38 patients divided randomly into two groups. All patients received standard treatment (paste impregnated bandage and a self-adhesive elastic bandage plus placebo ultrasound or ultrasound (1.0 watt/cm2 at 1 MHz, for 10 min) twice weekly for 8 weeks. Percentage healed ulcer area and number of healed ulcers were compared after 2, 4, 6 and 8 weeks. There were no significant differences in the proportion of healed ulcers or ulcer area in the ultrasound group as compared with the placebo group.

Adult↗
PubMed1991

Pulsed ultrasound treatment in lateral epicondylalgia.

This study was carried out to explore the pain-alleviating effect of pulsed ultrasound in lateral epicondylalgia. Forty-five patients were consecutively assigned at random to two groups for pulsed ultrasound or placebo. The parameters for ultrasound were 1 MHz; 1:4; 1 W/cm2. Each session was for 10 min, two to three times weekly, ten treatments in all. Follow-ups were done after three and twelve months. The statistical analysis showed no significant differences in relation to subjective or objective outcomes between the groups after the treatment period or at the follow-ups. Our results do not support the use of pulsed ultrasound treatment with the chosen parameters in lateral epicondylalgia.

Adult↗
PubMed1990

Influence of the nervous system on experimentally induced urethral inflammation.

We have studied the contribution of the nervous system on experimentally induced urethral inflammation in the rat. Urethral inflammation was induced by inserting latex strips into the urethra. The effects of different experimental procedures was assessed by using a 4-graded inflammation scale based on the histological findings. Attenuation of urethral inflammation was produced by administration of capsaicin at birth. A more complete attenuation was produced by sympathectomy prior to application of the latex strip. Urethral inflammation was also severe in the spontaneous hypertensive rat. Injection of morphine into the third ventricle of the brain significantly reduced the experimentally induced urethral inflammation. These data taken together indicate that the sensory and postganglionic innervation of the urethral mucosa as well as the central nervous system is critically involved in the inflammatory reaction of the urethra following exposure to latex strips.

Adrenergic Fibers↗
PubMed1990

Pseudomonas aeruginosa: adherence to and growth on different urinary catheter coatings.

Discs of urinary catheters with different coatings were exposed to a flow of artificial urine containing cells of Pseudomonas aeruginosa. Within 10 h an adherent biofilm consisting of the bacteria and their exopolysaccharide products had developed on those discs coated with latex, teflon, and silicon. In contrast, on the silver alloy-coated catheter discs no biofilm of Pseudomonas aeruginosa had developed.

Bacterial Adhesion↗
PubMed1990

Laser treatment applied to acupuncture points in lateral humeral epicondylalgia. A double-blind study.

Forty-nine patients suffering from lateral humeral epicondylalgia were enrolled in a double-blind study to observe the effects of Ga-As laser applied to acupuncture points. The Mid 1500 IRRADIA laser machine was used, wavelength: 904 nm, mean power output: 12 mW, peak value: 8.3 W; frequency: 70 Hz (pulse train). Localization of points: LI 10, 11, 12, Lu 5 and SJ 5. Each point was treated for 30 sec resulting in a dose of treatment of 0.36 J/point. The patients were treated 2-3 times weekly with 10 treatments in all. Follow-ups were done after 3 months and 1 year. No significant differences were observed between the laser and the placebo group in relation to the subjective or objective outcome after 10 treatments or at the follow-ups.

Acupuncture Points↗
PubMed1990

Acupuncture treatment in epicondylalgia: a comparative study of two acupuncture techniques.

The purpose of this study was to compare the pain-alleviating effect of classical acupuncture with superficial needle insertion in 82 patients suffering from lateral epicondylalgia. Sessions were 20 min long, two to three times weekly with 10 treatments in all. Five acupuncture points were treated: LI 10, 11, 12, Lu 5, and SJ 5. After 10 treatments significant differences were observed between the groups favoring the classical acupuncture technique in relation to subjective and objective outcome. No such differences could be observed at the follow-ups after 3 months and 1 year. This study showed that classical "deep" acupuncture is superior to superficial needle insertion in the short-term symptomatic treatment of lateral epicondylalgia, but not at 3- and 12-month follow-up.

Acupuncture Therapy↗
PubMed1990

Silver alloy coated catheters reduce catheter-associated bacteriuria.

The tendency of indwelling catheters to cause urinary tract infection was evaluated in a randomised clinical study of 223 patients. A Foley catheter coated with silver alloy on both inner and outer surfaces was used in 60 patients; 60 others received a Teflonised latex Foley's catheter and the remaining 103 patients were excluded because of antibiotic treatment, diabetes, etc. There was a statistically significant difference in the incidence of catheter-associated bacteriuria (greater than 10(5) organisms/ml) in the 2 groups after 6 days' catheterisation: 6 patients with the silver coated catheter developed bacteriuria compared with 22 who had the Teflonised latex catheter. This suggests that the silver impregnated urethral catheters reduce the incidence of catheter-associated urinary tract infection.

Bacteriuria↗
PubMed1990

Refinements in the coating of urethral catheters reduces the incidence of catheter-associated bacteriuria. An experimental and clinical study.

The tendency to develop bacteriuria during the use of various forms of indwelling catheters was evaluated in a randomized trial in 90 patients. A silver alloy and hydrogel-coated Foley catheter (SHC) was compared to a non-coated catheter (NC) and a catheter coated only with hydrogel (HC). Three patients (10%) with SHC catheters, 10 (33%) patients with HC catheters, and 15 (50%) patients with NC catheters developed bacteriuria (greater than 10(5) organisms/ml). The difference in the rate of bacteriuria after 5 days of catheterization was statistically significant between the SHC catheter and the NC catheter (p less than 0.002). There was no significant difference between the SHC catheter and the HC catheter, nor was there a significant difference between the HC catheter and the NC catheter. The toxic effects, as estimated by the IC50 value, of the urinary catheter material used was elucidated in an experimental fibroblast model. The IC50 value for the NC catheter was 33.9%, HC catheter 72.2% and for the SHC catheter 98.1%.

Bacteriuria↗
PubMed1990

Effects of electrical nerve stimulation (ENS) in ischemic tissue.

Blood flow was measured in the skin flaps of 20 patients who had undergone reconstructive surgery. All flaps were showing clinical signs of deficient circulation. Local blood flow in skin flaps was significantly increased by electrical nerve stimulation (ENS) (p less than 0.001), but not by placebo ENS. Repeated ENS treatment reduced stasis and oedema significantly (p less than 0.001), and the capillary refill was also significantly improved (p less than 0.001).

Adult↗
PubMed1990

Pulsed ultrasound does not improve healing of venous ulcers.

A controlled study of the effects of pulsed ultrasound was carried out in conjunction with a standard treatment for healing chronic leg ulcers on 44 patients divided randomly into two groups. All patients received standard treatment (paste impregnated bandage and a self-adhesive elastic bandage) plus placebo-ultrasound or pulsed ultrasound (1:9, 0.5 watt/cm2 at 1 MHz, for 10 min) 3 days a week for 4 weeks, thereafter twice weekly for 4 weeks and once weekly for the following 4 weeks. Percentage healed ulcer area and comparison of percentage healed ulcers were examined after 4, 8 and 12 weeks. There were no significant differences in the proportion of healed ulcers or ulcer area in the pulsed ultrasound group as compared with the placebo group.

Aged↗
PubMed1989

Immunoreactive tachykinins, calcitonin gene-related peptide and neuropeptide Y in human synovial fluid from inflamed knee joints.

We have analysed the concentrations of substance P (SP), neurokinin A (NKA), calcitonin gene-related peptide (CGRP) and neuropeptide Y (NPY) in the synovial fluid from 5 patients suffering from arthritis with inflamed knee joints as well as from 5 healthy control subjects with an earlier traumatic meniscal or cruciate ligament injury. Competitive radioimmunoassay was done using antisera SP2 (SP), K12 (NKA), R8 (CGRP), and NPY1 (NPY). No SP-like immunoreactivity (-LI) was detected in any patient. NKA-LI was found in all control patients but in none of the arthritis patients. CGRP-LI was seen in all arthritis patients as well as in 3/5 control patients, a non-significant difference. NPY-LI was found in a significantly higher concentration in the arthritis group vs the control patients. The results support an involvement of neuropeptides in human joint inflammation.

Adult↗
PubMed1989

Acupuncture and sensory neuropeptides increase cutaneous blood flow in rats.

The effect on blood flow of electro-acupuncture (EA) injection of substance P (SP) and calcitonin gene-related peptide (CGRP) was studied in musculocutaneous flaps in the rat, using laser Doppler flowmetry. The circulatory border was estimated before and after treatment. It was shown that treatment with EA increased the blood flow moving the circulatory border distally 66% after a treatment. Injection of NaCl into the dorsal central vein of the flap resulted in no increase in blood flow whereas SP 10(-9) M and CGRP 10(-9) M increased the blood flow so that the circulatory border moved distally 31% and 49%, respectively. It is suggested that the effect of EA on blood flow is similar to the effect achieved by injecting CGRP and SP.

Acupuncture Therapy↗
PubMed1989

Silver coating of urinary catheters prevents adherence and growth of Pseudomonas aeruginosa.

Discs of urinary catheter material were exposed to the flow of artificial urine containing cells of Pseudomonas aeruginosa. Within 10 h an adherent biofilm composed of the bacteria and of their exopolysaccharide products had developed on the uncoated catheter material. On the silver-coated catheter material no biofilm of Pseudomonas aeruginosa had developed.

Bacterial Adhesion↗
PubMed1989

Assessment of silver-coated urinary catheter toxicity by cell culture.

The toxicity of silver-coated urinary catheters was assessed using a cell culture technique. The inhibitory effect of catheter extracts on the uptake of 3H-labelled thymidine by mouse fibroblasts was measured. The results show that silver-coating had no toxic effect whereas silvernitrate and silversulphate coating did have a toxic effect.

Animals↗
PubMed1989

Increased survival of ischaemic musculocutaneous flaps in rats after acupuncture.

The effects of acupuncture on survival of ischaemic musculocutaneous flaps were investigated in the rat. A dorsal cranially based standard flap (2 X 7 cm) was elevated and sutured back in position. The percentage survival of the flaps was estimated after 6 days. Manual acupuncture, electro-acupuncture but not superficial acupuncture significantly increased the survival of the flaps compared to untreated controls. The highest flap survival (92%) was obtained with repeated post-operative high-intensity electro-acupuncture. It is concluded that acupuncture treatment markedly increases experimental flap survival and may be of clinical importance for treatment of local ischaemia.

Acupuncture Therapy↗