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Biomedical subjects

T Kozuka

Publications and source records attributed to T Kozuka.

At least 379 records · Page 21Linked to original sources

[Evaluation of tricuspid regurgitation by the ultrasonic pulsed Doppler technique from a transcutaneous approach (author's transl)].

Severity of tricuspid regurgitation was assessed by using a combined system of the ultrasonic pulsed Doppler technique and two-dimensional echocardiography from a transcutaneous approach. The study group comprised 47 patients with various heart diseases, who were clinically presumed to have tricuspid regurgitation, and 10 healthy subjects. 1) Pansystolic abnormal flow signal was detected in an area from the tricuspid valve into the right atrial cavity in 43 patients including 8 patients without definitive signs of tricuspid regurgitation. Such abnormal flow had never been detected in healthy subjects and was considered to represent tricuspid regurgitant flow. Tricuspid regurgitant flow usually exhibited a wide band spectrum of velocity component indicating a disturbed flow. In 4 patients with clinical signs of severe tricuspid regurgitation, a laminar flow was detected in the right atrial cavity, which was considered to indicate a regurgitant jet in the central part of tricuspid regurgitant flow. 2) The area where tricuspid regurgitant flow was detected was interpreted as revealing the main direction and spread of tricuspid regurgitant flow. Based on this finding, severity of TR was classified into 4 grades by the assessment on the basis of the distance reached by tricuspid regurgitant flow in the right atrium. Severity of tricuspid regurgitation was also classified into 4 grades by right ventriculography. The grade of tricuspid regurgitation assessed by Doppler technique was nearly consistent with that assessed by right ventriculography. Severity of tricuspid regurgitation was also classified into 4 grades on the basis of the extent of the area where the regurgitant flow spread, and nearly the same results were obtained as those described above. 3) Thus, the combined use of Doppler flowmetry and two-dimensional echocardiography proved to be useful for detecting tricuspid regurgitant flow and assessing the severity of tricuspid regurgitation.

Doppler Effect↗

Histopathological study on right endomyocardial biopsy of Kawasaki disease.

Fifty right ventricular endomyocardial biopsy specimens taken from patients with Kawasaki disease were studied. These were taken from 33 male and 17 female patients. Biopsies were examined for inflammatory cell infiltration, fibrosis, myocardial fibre disarrangement, and the cellular and nuclear changes of hypertrophy. A score of severity was prepared. The degree of abnormality was found to correlate with the duration of the disease, as did fibrosis found in 18 cases (36%), but inflammatory cell infiltration did not (13 cases, 26%). Coronary involvement was restricted to the male patients but the myocardial changes occurred in both sexes.

Cardiomegaly↗