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Biomedical subjects

T Kozuka

Publications and source records attributed to T Kozuka.

At least 397 records · Page 22Linked to original sources
PubMed1979

Brilliant Lake Red R as a cause of pigmented contact dermatitis.

Twenty-three patients suffering from pigmented contact dermatitis caused by cosmetics containing Brilliant Lake Red R were observed. Commercial samples of Brilliant Lake Red R proved to contain many ethyl acetate extractable impurities; 1-phenylazo-2-naphthol and azobenzene were isolated and identified. To determine the responsible allergens, five patients were examined by patch tests with purified samples of azo-dyes and the unidentified fractions of ethyl acetate extractable impurities. Three out of five showed weaker reactions to purified samples of Brilliant Lake Red R and the other two showed equal reactions compared to the commercial product. 1-Phenylazo-2-naphthol was found to be a strong allergen in all cases but none showed a positive reaction to azobenzene. Some unidentified fractions also gave positive results. Patch tests were performed with 4-phenylazo-1-naphthol, 4-phenylazo-1-naphthol-2-carboxylic acid, and 2,4-bis(phenylazo)-1-naphthol, as structurally related compounds derived from 1-naphthol. All gave negative and they were not detected in the ethyl acetate extractable impurities by thin-layer chromatography.

Adult↗
PubMed1979

Characteristics of ventricular function in single ventricle.

Funtional characteristics of the single ventricle were studied by means of biplane angiocardiography in 34 patients. Group 1 consisted of 14 patients with normal or increased pulmonary vascular marking on chest film and no pulmonary stenosis. Group 2 included 20 patients with severe angiographic pulmonary stenosis and decreased pulmonary vascular marking. Ventricular volume parameters were calculated according to Simpson's rule and were compared with normal values. The sum of the normal left and right ventricular volumes was assumed to be 100%. In group 1, ventricular end-diastolic volumes averaged 143 +/- 11% and were significantly (p less than 0.001) larger than end-diastolic volumes in group 2 (81 +/- 4%). The presence or absence of severe pulmonary stenosis affecting pulmonary blood flow was a main factor regulating the ventricular chamber size in single ventricle. In both groups, the ejection fraction of a single ventricle was significantly lower than that of a normal left or right ventricle. Ventricular size and function in patients with a single ventricle should be carefully assessed before ventricular septation surgery.

Angiocardiography↗
PubMed1978

A criss-cross heart with concordant atrioventriculo-arterial connections. Report of a case.

A distinctive angiographic appearance is described in a case of "criss-cross" heart with concordant atrioventriculo-arterial connections. The atrial situs was normal, and the morphological right ventricle was superior to the left ventricle, and the ventricular septum was horizontal in position. Both ventricleswere connected by a small ventricular septal defect. The aorta was situated anteriorly and to the right of the pulmonary artery. Although the cardiac segment was the apparent [S,L,D] type, the heart had conconrdant atrioventriculo-arterial connections. The ventricular rotation of the solitus heart about the longitudinal and the anteroposterior axis affected the atrioventricular flows, the plane of the ventricular septum, the inflow and outflow tracts of the ventricles, the interrelationship of the great arteries, and the course of the left coronary artery. Using the recent definition of criss-cross heart, we classified the heart as solitus-concordant (l-rotated) -normal.

Arteries↗
PubMed1977

Angiocardiography after total correction of tetralogy of Fallot using large homograft arteries.

Postoperative angiocardiographic findings were examined in eight patients whose pulmonary artery was reconstructed using an aortic or pulmonary homograft with valve. Apparent dilatation of the outflow tract of the right ventricle was seen in three patients. Only four showed valve mobility, with function judged almost normal in two of them. Calcification in a valve was not seen. The pulmonary trunk showed three directional patters, and stenosis was clearly observed in two cases. calcification of the pulmonary trunk was seen in only one case. The most difficult problem in the reconstruction of the pulmonary artery is the high incidence of pulmonary stenosis.

Adolescent↗
PubMed1977

DNA repair characteristics and skin cancers of xeroderma pigmentosum patients in Japan.

Fifty xeroderma pigmentosum patients in Japan were examined for clinical characteristics and DNA repair of their cells, Skin cancers developed in 22 patients. Most of the patients without skin cancers were children, except for 5 older patients who had intermediate or nearly normal levels of DNA repair in their cells. All patients younger than 10 years old had no or very low activity of unscheduled DNA synthesis after ultraviolet light irradiation. Three genetic complementation groups, A, D, and E, and variants were found. Many Group A patients and no Group C patients characterized Japanese patients, compared with those in Europe and the United States, where Group C patients were most frequent. The high frequency of patients with low DNA repair capacities in their cells may account for the apparent high frequency of xeroderma pigmentosum patients in Japan. Age distribution of the cancer-bearing patients and their DNA repair characteristics suggest that almost all xeroderma pigmentosum patients will develop skin cancers unless their cells have nearly normal levels of DNA repair.

Adolescent↗
PubMed1976

Intraventricular repair of single ventricle associated with transposition of the great arteries.

Intraventricular repair was performed successfully in a 6-year-old body having a ventricle associated with d-loop and d-transposition in situs solitus of the atria and viscera. A spiral Teflon patch was utilized to partition the ventricle. Complete heart block did not result, and the patient is doing well 8 months after the operation. Details of the pre- and postoperative studies, as well as details of the surgical technique, are presented. A review is presented of the operative procedures that have been designed for the correction of a single ventricle associated with transposition of the great arteries and have been reported previously in the literature. The advantages for use of the techniaue employed in the present case are discussed.

Angiocardiography↗