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Biomedical subjects

T Kitamura

Publications and source records attributed to T Kitamura.

At least 793 records · Page 44Linked to original sources
PubMed1981

Serum beta 2--microglobulin and carcinoembryonic antigen in patients with gastric disorders.

A comparative study of carcinoembryonic antigen (CEA) and beta 2-microglobulin in serum was made by radioimmunoassay in 121 patients with gastric disease. There was no statistical difference in serum CEA and beta 2-microglobulin in patients with benign gastric disease, early gastric carcinoma, and advanced gastric carcinoma. However, CEA levels in patients with advanced gastric carcinoma were higher than those in benign gastric disease and in early gastric carcinoma but beta 2-microglobulin did not show and differences. Furthermore, after total removal of the tumor, the elevated CEA levels decreased but beta 2-microglobulin remained unchanged. We concluded that CEA appeared to predict tumor behavior more accurately in patients with gastric carcinoma than beta 2-microglobulin.

Adult↗
PubMed1981

Immunofluorescence studies of the monocytes in the injured rat brain.

Rat brain was obtained on the 4th day after its damage by a stab wound. The injured and the normal control brain tissues were stained by the immunofluorescence technique using anti-granulomonocytic rabbit serum. After the fluorescence observation the same tissues were further stained by hematoxylin and eosin (HE) and studied comparatively by light microscopy. The following results were obtained: (1) The normal adult rat brain lacks the cells which react with the antiserum, thus the resting microglia occurring in the normal adult brain are antigenically different from the cells of the monocyte-macrophage system. (2) In the injured brain tissues monocytes extravasate, enter-brain parenchyma, and take ameboid forms or become macrophages. (3) Among the reactive cells in the injured brain, all of the brain macrophages and most of the ameboid cells were reactive with the antiserum thereby indicating their monocytic origin.

Animals↗
PubMed1981

Effect of albumin on amylase assay using blue starch polymer.

The nature of the stimulation by albumin of amylase activity determined by use of blue starch polymer was studied. The binding of albumin to the starch polymer was responsible for the stimulation of amylase activity, since the stimulation was observed with the albumin-bound blue starch polymer as substrate irrespective of the presence or absence of free albumin in the reaction mixture. When the albumin-bound blue starch polymer was hydrolysed by amylase, the blue oligosaccharide fragments were released with the albumin attached. These oligosaccharide fragments were about 1.3 times larger in average molecular size than the fragments released in the absence of albumin, suggesting that the apparent stimulation of amylase by albumin, (about 1.3 times) is due to the liberation of the larger oligosaccharide fragments.

Amylases↗
PubMed1981

Idiopathic gastric volvulus in infancy and childhood.

Idiopathic gastric volvulus is not rare, especially in the neonate and in infancy. Between 1966 and 1980 we managed 44 cases of gastric volvulus. In 22 of the cases, initial examination was performed under 1 year of age. The main symptoms in this group were vomiting and abdominal distention, while those in the group over 2 years of age were abdominal distention, weight loss, nausea, appetite loss etc. The upper G.I. series were the most important in diagnosis. There was only one case of acute volvulus, which was treated operatively on an emergency basis. Chronic volvulus could be treated conservatively, except in 2 cases. This consisted in the positioning of the patient in the upright right recumbent position after feeding, for at least 1 hour. In the supine position, the gastric fundus is filled and dilated when the milk is poured into the stomach, the fundus is pulled postero-caudally and the antrum is pulled upwards, resulting in the combined type of organo-axial and mesenterico-axial volvulus. Over 2 years of age, 77% required operation. The fixation of the gastric fornix with the diaphragm was performed, using 5 or 6 stitches. The result was quite satisfactory. We recommend this procedure in this operation.

Acute Disease↗
PubMed1981

Distribution of fibrous long-spacing fibers in normal and pathological lymph nodes.

The occurrence and distribution of fibrous long-spacing fibers (FLS) of lymph nodes in normal and pathological conditions have been examined by electron microscopy. The FLS can be easily identified by the characteristic broad cross bands with a 90 to 120 nm period. In normal lymph nodes, the FLS were most often found in the stalk of the valve projecting into the lymphatic sinus and in the perivascular matrix, and less frequently in the wall of the vein, in the sinus wall and in the stroma of the medulla at the hilus. In pathological conditions, a large number of FLS appeared in the hyalinous matrix of lymphocyte depletion type of Hodgkin's disease. These fibers were also observed in reticular matrices of lymphosarcoma and mixed cellularity type of Hodgkin's disease as well as in granulation tissues. It was noted that FLS appeared to be formed in the regions where abundant reticular fibers were laid down. Compared with the ultrastructural and histological findings in various lesions of lymph nodes, the possible mechanism and significance of FLS were discussed.

Adult↗
PubMed1981

Occupationally-acquired smallpox in an IgM-deficient health worker.

A 21-year-old Indian who worked as a vaccinator in the smallpox programme developed an atypical case of variola major despite several previous, successful vaccinations. The clinical course of the disease was unusual, as there were two distinctly separate "crops" of smallpox. The disease began less than one month after a successful vaccination, which therefore gave the briefest period of protection recorded for this reliable immunization. The patient was found to have a virtually complete IgM deficiency with normal levels of circulating antibody against orthopox virus.

Adult↗
PubMed1980

Histopathologic studies of benign infantile hemangioendothelioma of the parotid gland.

Five hundred and eighty-four cases of primary parotid gland tumors and tumor-like conditions were examined. Primary benign hemangiomas of the parotid gland were relatively rare, comprising 29 cases (4.9%) of 584 tumors. These could be divided into either cavernous hemangioma or so-called benign hemangioendothelioma. In our series, the incidence of the latter was 1.5% (nine cases), or 31.0% of the total number of hemangiomas. The so-called benign hemangioendotheliomas were found in patients under the age of 12 months, during the infantile period, and occurred predominantly in females and on the right side. Histologically, this tumor showed a uniform growth pattern so that each lobular portion exhibited a strikingly identical appearance. The vascular lumina of the tumor were lined by flattened endothelial cells that were occasionally mixed with some plump cells showing mild atypism. Electron microscopy revealed that the tumor consisted of two distinct components, one being definite endothelial cells lining the vascular channels and the other pericytes located outside of the endothelium embracing the vascular channels. The tumor cells can be interchangeable with one another. It seems that this tumor is derived from the intralobular vascular system of the parotid gland. This tumor is benign in nature and found almost exclusively during the infantile period. Hence, from the clinicopathologic aspect, "benign infantile hemangioendothelioma" seems to be a more suitably descriptive term than simply "benign hemangioendothelioma".

Adolescent↗
PubMed1980

Carcinoembryonic antigen-like activity in gastric juice and plasma in patients with gastric disorders.

Carcinoembryonic antigen (CEA)-like activity in gastric juice and plasma was examined in patients with gastric disease. There was no statistical difference in plasma CEA in normal subjects and in patients with benign gastric cancer. However, four patients with advanced gastric cancer, one with stage III and three with stage IV disease had a very high plasma CEA level. There was significant differences in CEA-like activity in gastric juice in patients with benign gastric disease and early gastric cancer (p less than 0.01) and patients wih benign and advanced gastric cancer (p less than 0.001). These results suggest that measurement of CEA-like activity in gastric juice is a useful adjunct to the diagnosis of early malignant changes in the stomach.

Adult↗
PubMed1980

Parathyroid adenoma found by vertebral vein sampling.

We report on a 33-year-old man with hypercalcemia and recurrent nephrolithiasis, who underwent the first neck exploration for primary hyperparathyroidism on September 27, 1973. No tumor was found and bilateral upper normal parathyroid glands were removed. However, hypercalcemia persisted postoperatively. Selective venous sampling for radioimmunoassay of parathyroid hormone 5 years later revealed a sharp unilateral gradient in the right vertebral vein. On November 2, 1978 the second neck exploration was performed and a right lower parathyroid adenoma was removed from the right lateral wall of the esophagus. Postoperatively, the serum calcium level decreased to 8.8 to 9.3 mg./dl. and convalescence was uneventful. In this case the pathway of parathyroid venous effluent might have been changed by the previous neck exploration and probably drained anomalously through the vertrbral vein. Selective venous sampling for radioimmunoassay of parathyroid hormone should include samplings from the vertebral veins as well as the thyroid veins, especially in cases with 1 or more previous neck explorations.

Adenoma↗
PubMed1980

Dynamic aspects of glial reactions in altered brains.

We investigated cellular reactions in altered brain with electron microscopy, 3H-thymidine autoradiography and immunohistochemistry. Comparing the results to those of classical studies with silver-impregnation method, following conclusions were obtained: 1. Full-blown macrophages, "amoeboid microglia", "rod cells" in acute viral encephalitis and "true" inflammatory cells in retrograde degeneration are derived from circulating mononuclear leukocytes which enter into brain parenchyma after the injuries. 2. Microglia, pericytes and other indigenous cells in brain parenchyma do not contribute to the macrophage formation. 3. Silver-impregnated resting microglia are definite cell group existing in the normal brain parenchyma. They are separate kind of cells from oligodendroglia or from mononuclear leukocytes. 4. In response to brain damage the resting microglia show marked swelling in the nucleus and cytoplasm, then, proliferate actively. After division they transform into reactive, fibrous astroglia. 5. Therefore, resting microglia are considered to be the reserve cells of fibrous astroglia.

Animals↗