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Biomedical subjects

T Kitamura

Publications and source records attributed to T Kitamura.

At least 775 records · Page 43Linked to original sources
PubMed1982

Clinical, hematologic, and pathologic features of leukemic T-cell lymphoma.

Cells obtained from malignant lymph nodes and the peripheral blood of 106 patients with non-Hodgkin's lymphomas were examined for T- and B-cell characteristics. Surprisingly, 79 cases were of the T-cell type on the basis of spontaneous rosette formation with sheep erythrocytes (E-rosettes). Of the remaining cases, 15 were B-cell in nature (monoclonal S-Ig positive), seven were non T-, non B-cell and four cases were undetermined. Forty-nine (62.0%) of the T-cell malignancies were of a leukemic variety, characterized by pleomorphism in the peripheral blood cell size, and histological appearance. Most of the leukemic T-cells showed obvious lymphocytic differentiation, with condensed nuclear chromatin and scant cytoplasm, although in many of the cases, the lymphomatous infiltrate was dominated by large or pleomorphic lymphoid cells. All tumors were of a diffuse variety, and on histologic examination included a mixed type (21 cases), PDLL forms (15 cases), a large lymphoid cell type (eight cases), and WDLL forms (five cases). Although the mixed type with a pleomorphic lymphoid infiltrate was distinctive, there has been considerable variation from case to case. Clinically this unusual t-cell, leukemic variety of non-Hodgkin's lymphomas primarily involved middle-aged and elderly subjects, and was characterized by wide spread organ invasion (preferentially to the liver, spleen and skin), resistance to chemotherapy, and a poor prognosis. A mediastinal mass was not observed in all cases. The patients had a median survival of only ten months.

Adolescent↗
PubMed1982

Histopathologic studies of undifferentiated carcinoma of the parotid gland.

Five-hundred-fifty-five primary epithelial tumors of parotid gland origin were examined. Eighteen cases could be defined undifferentiated carcinomas, constituting 3.2% of the total number or 10.2% of 176 malignant tumors. The undifferentiated carcinomas could be divided on the basis of the cell size into two types: (1) Small-cell type (12/18; 66.7%); the tumor cells were as large as, or slightly larger than lymphocytes. The cytoplasm was scanty with dark chromatin. Mitotic figures were numerous. The tumor cells in the periphery of the cell clusters exhibited a palisading arrangement. Electron microscopy revealed that these cells were rich in tonofilaments and connected by desmosomes. (2) Large-cell type (6/18; 33.3%); the carcinoma cells were roughly twice as large as those of the small-cell carcinoma. The tumor cells were spheroidal or spindle in shape with rich and clear cytoplasm. Many of the tumor-cell clusters showed macroalveolar structures, suggesting the possibility that this type occurred as a variant of poorly differentiated adenocarcinoma or epidermoid carcinoma. Clinicopathologically, there was no sex difference in the total number of the undifferentiated carcinomas, but the large-cell carcinomas were frequently encountered in females (83.3%). As to the age distribution, the carcinomas were found frequently in middle-aged patients from 30-49 years (66.7%). Many of the tumors were 2-4.9 cm at their greatest diameter (55.6%). Tumor mass less than 1.9 cm could not be found.

Adult↗
PubMed1982

Histopathologic studies of basal cell adenoma of the parotid gland.

Five-hundred-thirty-one cases of primary epithelial tumors of the parotid gland were examined. The incidence of basal cell adenomas was 7.5% (40 cases). The tumors could be classified histologically into these subtypes: basal cell (21/40; 42.5%); tubular, (13/40; 32.5%); trabecular (4/40; 10.0%); and papillary (2/40; 5.0%). The pattern of classic basal cell adenoma predominated in the basal-cell type but was also seen in varying degrees in the latter three types with a reciprocal transition. Accordingly, it could be suggested that tubular, trabecular, and papillary types are variants of basal cell adenoma. The higher incidence of basal cell adenomas in our survey could be accounted for by this categorization. Histologically, basal cell adenomas presented various features; (1) cystic formation (26/40; 65.0%), being most frequently seen in tubular and trabecular types; (2) adenoid cystic pattern (4/40; 10.0%); (3) elastosis in the stromal tissues (2/40; 5.0%). Basal cell adenomas were clinicopathologically compared with 291 cases of pleomorphic adenomas. Basal cell adenomas were seen more often in female patients, (60.0%), as were pleomorphic adenomas (68.4%). They were observed more frequently in patients over 50 years of age and the average was ten years higher than for pleomorphic adenoma. The tumor size tended to be smaller (below 2 cm at the greatest diameter) than pleomorphic adenomas.

Adenoma↗
PubMed1982

Tamm and Horsfall glycoprotein does not promote spontaneous precipitation and crystal growth of calcium oxalate in vitro.

Tamm and Horsfall glycoprotein was isolated from urine of patients with renal stones and from normal control subjects, and tested for its effects on the crystallization of calcium oxalate in vitro. Preparations from both groups (10-100 micrograms./ml.) caused slight inhibition of spontaneous precipitation and crystal growth of calcium oxalate. No promotion was found.

Calcium Oxalate↗
PubMed1982

Partial biochemical and physicochemical characterization of organic macromolecules in urine from patients with renal stones and control subjects.

From the urine of patients with calcium nephrolithiasis, and of control subjects, we isolated organic substances according to molecular size and tested them for effects on calcium oxalate precipitation. Nine subgroup materials of varying sizes were prepared by ultrafiltration and Sephadex G-200 column chromatography from 10 stone-formers, as well as from 10 control subjects. Uromucoid was found in large materials of both groups, whereas glycosaminoglycans were detected in large- and medium-sized materials of both groups. The small materials were devoid of uromucoid and glycosaminoglycans, but contained protein and uronic acid, a finding suggesting that they may be glycoproteins. The daily excretion of the uromucoid-rich material was greater, but that of the small glycoproteins was lower in stone-formers than in control subjects. The largest-sized material from stone-formers was devoid of any activity on calcium oxalate precipitation. All of the remaining materials (at a concentration of 5 mg/dl) exerted inhibition on calcium oxalate precipitation. The inhibition rose progressively with the decreasing size of organic materials. The calculated total inhibitor activity for the stone-forming group was 36% lower than that obtained in the control group.

Adult↗
PubMed1982

Time passes slowly for patients with depressive state.

Twenty-three depressive inpatients and the same number of matched non-psychiatric controls were examined on three occasions - following admission, 14 days after, and 28 days after the admission - by administering a self-rating questionnaire of time awareness and Hamilton's Rating Scale for Depression (HRS). The patients were found to feel time passing slowly. This was correlated with the severity of depression expressed as the total HRS score. No significant differences emerged between diagnostic groups, namely endogenous depression, neurotic depression, and schizophrenia or paranoid state with depressive symptoms. Correlations of the time awareness with symptoms listed in the HRS also denied a specific relationship of time awareness to specific diagnoses. The subjective feeling of slow time flow reflects, therefore, the depth of depressive state in general, which is nevertheless not specific to any diagnostic subcategory.

Adult↗
PubMed1981

Histopathologic studies on carcinoma in pleomorphic adenoma of the parotid gland.

Five-hundred-eighteen cases of primary epithelial tumors of the parotid gland were examined. The incidence of carcinomas in pleomorphic adenoma was 9.3% (48 cases). In addition to cellular atypism, the following histological findings were thought to be important criteria for the diagnosis of carcinomas: (1) capsular invasion, (2) infiltration into adjacent organs, (3) proliferation of atypical cells within fibrous tissues and chondroid matrix in the area of pleomorphic adenoma, (4) vascular involvement, and (5) mitotic figures. Pleomorphic adenomas (282 cases) were found predominantly in females (70.8%), at the age of 30 to 49 (48.2%), whereas carcinomas in pleomorphic adenoma were more often found in males (70.8%) and at the ages over 50 (43.8%). Histologic types were composed mostly of undifferentiated carcinoma (56.2%) and adenocarcinoma (37.5%). The prognosis of the carcinomas, especially the undifferentiated type, was generally poor; about 45% of the cases either experienced recurrence or died within five years. Electron microscopy on this undifferentiated carcinoma revealed characteristic filamentous structure in the carcinoma cells, resembling that observed in myoepithelial cells. It was assumed that the undifferentiated carcinoma cells were of myoepithelial origin.

Adenoma, Pleomorphic↗