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Biomedical subjects

T Kitamura

Publications and source records attributed to T Kitamura.

At least 685 records · Page 38Linked to original sources
PubMed1986

[Clinicopathological study of minute stomach cancer].

During the last 10 years, we have experienced 41 cases of minute cancer, which is equivalent to 13.9% of all resected early stomach cancers. Out of 44 lesions in 41 cases, 17 lesions were diagnosed preoperatively, while 27 were unexpectedly detected by serial sections of the resected stomach. Most lesions were located along the lesser curvature of the body and antrum. There was no nodal involvement or vessel permeation. Histologically differentiated adenocarcinomas were encountered in 86.4%, associated with intensive intestinal mucosa in many cases. We have stressed that dye endoscopy using indigo carmine and methylene blue is very useful for the diagnosis of minute cancer.

Adenocarcinoma↗
PubMed1986

[Radiation-induced differential responses of uterine adeno- and squamous cell carcinoma spheroids in dose-survival relationships].

Radiation-induced dose-survival relationships of human uterine adeno and squamous carcinoma cells grown as spheroid were studied, comparing them with monolayer cells. HEC-59 and SKG-3a cell lines were used. The spheroids were produced by Yuhas's method. In monolayer culture, D0,Dq and n values in the Hit-theory were as follows: HEC-59 (D0 = 1.6Gy, Dq = 0.6Gy, n = 1.5) and SKG-3a(D0 = 1.3Gy, Dq = 0.4Gy, n = 1.4). Survival curves of both cell lines as spheroids demonstrated biphasic curves after acute irradiation. HEC-59 cells grown as spheroids 300 microns in diameter did not have a great second component. SKG-3a cell, however, did apparently have a large amount of the second component when a 6Gy dose was exceeded. The shoulder in the dose-survival curves of both cells grown as spheroids became greater than monolayer cells up to 3Gy dose. It was therefore proven that spheroids possess similar characteristics to solid tumors. This suggests that spheroids are useful in studying radiation-induced effects in solid tumors.

Adenocarcinoma↗
PubMed1986

[Radiation-induced cancers following radiotherapy of benign diseases: the second mail survey in Japan].

On a second mail survey (in 1984) concerning radiation-induced cancer following radiotherapy for benign diseases, 86 cases were collected from 95 hospitals in Japan. Adding these to 150 cases collected in the previous survey in 1979, 236 cases were accumulated. This is a report on the analysis of the 236 cases from a clinicopathological viewpoint. Underlying diseases consisted of cervical tuberculous lymphadenitis (125 cases), skin diseases (41 cases), benign thyroid diseases (19 cases), hemangioma (18 cases) and others (33 cases). Radiation-induced cancers, which were defined as cancers originating in the radiation field, including leukemia, consisted of hypopharyngeal cancer (68 cases), skin cancer (61 cases), laryngeal cancer (26 cases), esophageal cancer (23 cases), thyroid cancer (23 cases), salivary gland tumor (8 cases) and others (27 cases). Multiple primary cancers in the radiation field were observed in 7 cases. Average latent period was 28.9 years. It was demonstrated that the older the age at irradiation the shorter the latent period. Based on the population irradiated for benign diseases before 1977, which was collected in the first mail survey, incidence of radiation-induced cancers was estimated to be about 0.9%. The incidence varied with the period of radiotherapy; 1.9% for the period of radiotherapy before 1955, 0.4% for 1956-1965, 0.1% for 1966-1977. Although radiotherapy is now rarely indicated for benign diseases, it was shown in the first mail survey that more than 15,000 cases of benign diseases had been irradiated after 1956. It seems to be reasonable to consider that radiation-induced cancers after radiotherapy for benign diseases may continue to be discovered for several years in the future.

Adolescent↗
PubMed1986

[Radioresistant elements in adenocarcinoma of the uterus].

Radioresistant elements in adenocarcinoma of uterine cancer were studied using SKG-3a and HEC-59 cell lines as spheroids and monolayer culture. Dose-survival curves for monolayer cultured SKG-3a and HEC-59 cells were almost similar at acute exposure. On the other hand, as spheroids grown to 300 microns in diameter, dose-survival curves for SKG-3a cells were biphasic and those for HEC-59 were monophasic. The increased shoulder in survival curves proved the contract effect of both cells. Conventionally fractionated irradiation promoted shrinkage and disintegration of spheroids as the dose was increased. All SKG-3a spheroids were destroyed over 60 Gy, but some of HEC 59 spheroids survived over 68 Gy at the total dose. The total dose at disintegration-50% was 40 Gy in SKG-3a and 48 Gy in HEC-59 spheroids. In a comparison of single with 5-fractionated irradiation, fractionation induced an increase in radioresistance of adenocarcinoma cells. The maximum recovery-dose of HEC-59 cell as spheroids was 0.4 Gy and that of SKG-3a was 0.28 Gy. The magnitude of PLD-repair in HEC-59 cells was greater than that in SKG-3a. In conclusion, the PLD-repair and contact effect could be more important factors than the hypoxic element in the acquisition of radioresistance in adenocarcinoma cells as a solid tumor under fractionated irradiation.

Adenocarcinoma↗
PubMed1986

Indirect measurement technique for a portable artificial heart drive system.

Monitoring of blood pressures is essential to the physiological control of the blood circulatory system when artificial hearts are used. Efforts to obtain long term, reliable direct measurements of blood pressures have not been successful because of blood clotting impairing the function of sensors, baseline drift, artifacts on measurements, and health hazard-related catheterization. This paper is concerned with an on-line estimation technique of blood pressures for a portable artificial heart drive system. The technique is based on measurements made for the drive system outside of the body and on mathematical models of the drive system components. The test of the on-line estimation technique with a mock circulatory loop showed successful correlations between the actual values and their optimal estimates. The developed approach offers the following advantages: elimination of blood clotting problems, accessibility to the pressure transducer for recalibration, and noninvasive location of the transducers.

Blood Pressure↗
PubMed1986

Application of Research Diagnostic Criteria and International Classification of Diseases to case vignettes.

Thirty-one case vignettes prepared by the New York State Psychiatric Institute for the Research Diagnostic Criteria (RDC) reliability training were read and independently rated by four Japanese psychiatrists using the RDC and the ICD-9. The psychiatrists obtained the same interrater reliability with both systems for the diagnoses of schizophrenia, schizoaffective disorder, manic type, and major depressive disorder. Reliability was initially low for the RDC diagnoses of schizoaffective disorder, depressed type, and schizotypal features, but an eventual agreement was reached, concordant with the opinion of the New York experts. Case vignette training may enable non-English-speaking psychiatrists to handle the RDC as effectively as the ICD-9.

Cross-Cultural Comparison↗