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Biomedical subjects

T Iwa

Publications and source records attributed to T Iwa.

At least 181 records · Page 10Linked to original sources
PubMed1986

Length-based Fourier analysis in the pre-excitation syndrome.

Length-based Fourier analysis (LFA) was applied to tomographic gated blood-pool study, and phase and percent-shortening diagrams were generated. In 22 patients with pre-excitation syndrome and ten control subjects, the most basal short-axis section was used for tomographic analysis. When the initial abnormal phase was considered as the location of accessory conduction pathway (ACP), correct diagnosis for the localization of ACP was given in 19 of 22 patients. In ten control subjects, no specific segments of initial phase were noted, although six patients had initial phase in the septal or paraseptal segments. The tomographic LFA was more effective for pinpointing the segment of the earliest phase than tomographic count-based phase analysis. The LFA provided objective three-dimensional information for contraction sequence. Because movements of ventricular edges are essential in tomography, the LFA was considered to be a reasonable approach for the analysis of tomographic gated blood-pool study.

Erythrocytes↗
PubMed1986

[Surgery and adjuvant therapy of non-small cell lung cancer].

Bronchial arterial infusion of chemotherapeutic agents (BAI), radiation therapy, chemotherapy and immunotherapy were used as surgical adjuvant therapy for non-small cell lung cancer, and the clinical effects of these treatment modalities on survival rates were evaluated. BAI brought about a decrease of tumor size, but no significant effect on survival rats was noted. Postoperative radiation therapy on P-N2 cases exerted no significant effect on the survival rate, but when immunotherapy was combined with radiation therapy, there was a significant prolongation of the survival rate. As for post-operative chemotherapy, three types of combination chemotherapy have been performed over the past twelve years: short-term chemotherapy (S-C), long-term intermittent chemotherapy (L-I-C), and long-term continuous chemotherapy (L-C-C). Retrospective comparison of survival rates between these three methods was carried out. The survival rate of the group which was treated by L-I-C showed better results than those obtained by S-C. The group treated by L-C-C showed a much better survival rate than that treated by L-C-C: Stage I + II cases that underwent curative resection and were treated by L-I-C showed a significantly better survival rate than those treated by S-C. Furthermore, the survival rate of stage III cases with curative resection was improved by L-C-C (CQ+CPA+ADM+5-FU) with statistical significance. To evaluate the clinical efficacy of OK-432, a streptococcal preparation, as an immunotherapeutic agent for lung cancer, patients admitted between 1975 and 1982 were randomized into two groups: (1) an immunochemotherapy group and (2) a chemotherapy group (control group). For both groups, the same L-I-C was administered in accordance with the cancer histological cell type. There were 119 resected cases in the immunochemotherapy group and 115 cases in the control group, that were eligible for evaluation of long-term survival after surgery. Overall, the cases in the immunochemotherapy group showed a better survival rate than the control group, and this difference was statistically significant. In addition, statistically significant improvements of survival rate by the immunotherapy were observed for the following items; resected stage I + II cases, resected stage III + IV cases, cases with curative resection, cases with non-curative resection and resected epidermoid carcinoma. On the other hand, there were no statistically significant differences between the two groups in cases of adenocarcinoma.(ABSTRACT TRUNCATED AT 400 WORDS)

Adenocarcinoma↗
PubMed1986

[A new anticancer preparation, 5-fluorouracil-poly-L-lactic acid microcapsule, and its therapeutic evaluation].

An attempt was made to develop the new anticancer drug inducing enhanced tumor response to arterial chemoembolization therapy. 5-Fluorouracil (5-FU) was microencapsulated with poly L-lactic acid by the organic phase separation technique. This granular preparation containing 5-FU (FU-PLA-mc) was about 200 micron in diameter and was about 40% in 5-FU content. The release of 5-FU in vitro from FU-PLA-mc gradually increased, extending over 50 hours to reach maximum level. When 75 mg of FU-PLA-mc (5-FU content, 30 mg) was infused into normal rabbits through femoral arteries, maximum level of 5-FU in blood was 1.03 +/- 0.16 microgram/g after 15 minutes. Meanwhile, arterial infusion of the same dosage of FU-PLA-mc into VX2 tumor bearing rabbits resulted in the production of high level of 5-FU (2.1 +/- 0.5 micrograms/g) in tumors even after 72 hours. In vivo anticancer effect of FU-PLA-mc was significantly demonstrated; when 75 mg of FU-PLA-mc was administrated to VX2 tumor bearing rabbits through arterial infusion, T/C ratio of mean tumor weight was 0.01% on the 14th day after infusion. After hepatic arterial embolization with FU-PLA-mc in normal rabbits, elevation of serum transaminases was observed, but it was transient. Hepatic arterial chemoembolization with FU-PLA-mc was carried out for 8 patients with hepatic malignancies. Of these 8 patients, partial response was obtained in 3 patients and no severe complication was observed.

Adult↗
PubMed1986

Radical surgical cure of Wolff-Parkinson-White syndrome: the Kanazawa experience.

Between 1973 and 1983, we operated on 160 patients with Wolff-Parkinson-White syndrome at Kanazawa University Hospital; 126 had Wolff-Parkinson-White syndrome alone, and 34 had combined cardiac diseases. Of the 160 patients, 140 were completely cured; postoperatively, they had no delta wave on electrocardiograms and no tachycardia attacks. In 11 patients, the delta wave reappeared an average of 56 days after operation. They, and three other patients with concealed Wolff-Parkinson-White syndrome, experienced several postoperative episodes of tachycardia. However, in 12 of the 14 patients with postoperative tachycardia attacks, these disappeared completely in the course of a long follow-up period and these patients are also considered to be cured symptomatically. In the two remaining patients, the tachycardia attacks persisted. Of the 126 patients with Wolff-Parkinson-White syndrome alone, none died as a direct result of the operation. Patients with combined cardiac diseases other than cardiomyopathy, mild Ebstein's anomaly, or venous abnormality were treated in one operation. Six of the 34 patients with combined cardiac diseases died. In none of the 160 patients was the His bundle intentionally interrupted as an alternative method of interrupting the accessory conduction pathway. Our study showed that life-threatening arrhythmias occur more often than expected in patients with Wolff-Parkinson-White syndrome and the tolerance for tachycardia attacks differs from patient to patient. Because the surgical treatment of Wolff-Parkinson-White syndrome is safe and reliable, as indicated in this report, the radical correction of this disease should be considered in carefully evaluated patients.

Adolescent↗
PubMed1986

[Intra-abdominal administration of CDDP in the management of carcinomatous peritonitis].

Seven patients with carcinomatous peritonitis were intraperitoneally treated with CDDP. This procedure does not require specific hydration transfusion and much less diuretic. According to Koyama and Saito's criteria, one patient showed complete response, 5 showed partial response and one no change. Following this therapy, 4 patients have lived for more than 6 months. Renal toxicity, which is considered to be the most serious side effect of CDDP, was not found. Alimentary symptoms (nausea, vomiting) were noted in all patients and myelosuppression and abdominal bleeding were recognized in a small number of patients. In conclusion, our method is considered to be advantageous in the treatment of carcinomatus peritonitis.

Adult↗
PubMed1985

Nuclear tomographic phase analysis: localization of accessory conduction pathway in patients with Wolff-Parkinson-White syndrome.

The purpose of this study was to evaluate the usefulness of tomographic phase analysis in detecting the site of the accessory conduction pathway (ACP) in patients with Wolff-Parkinson-White (WPW) syndrome. Gated emission computed tomography and planar gated blood pool scintigraphy were performed in 20 patients with WPW syndrome, 14 with delta waves and six without delta waves (two intermittent types and four concealed types). The abnormal initial contractions in both planar and tomographic phase images were compared with the sites of ACPs confirmed by epicardial mapping and surgery. The atrioventricular ring was divided into eight segments on each side, and the identification of the initial phase in the segment in which the ACP was located, or that adjacent to it, was considered to be the correct diagnosis. In planar phase analysis, the abnormal initial phase was identified correctly in 8 of 14 patients (57%), whereas in tomographic phase analysis, the site of the ACP was detected in 12 of 14 patients (86%). Tomographic phase analysis can be a helpful adjunctive method in patients with WPW syndrome.

Adolescent↗