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Biomedical subjects

T Goto

Publications and source records attributed to T Goto.

At least 829 records · Page 46Linked to original sources
PubMed1982

[Tissue distribution of fortimicin used in the field of obstetrics].

A new aminoglycoside antibiotic, fortimicin, was administered intramuscularly at a dose of 200 mg, and the tissue distribution of the drug was investigated with time-course in the uterine fundus, uterine cervix, oviduct, endometrium and ovary. Patients who required total hysterectomy or uterine appendices resection due to uterine myoma, etc. were studied. The uterus levels of fortimicin were about 2 mcg/g at 2 hours after intramuscular administration in the uterine fundus and uterine cervix and reduced to trace after 8 approximately 9 hours. The genital organs levels of fortimicin were ranged from 0.71 to 4.6 mcg/g at 1 approximately 3 hours after intramuscular administration and then reduced to the levels of 0.79 mcg/g in the oviduct, of 0.25 mcg/g in the endometrium and of 0.45 mcg/g in the ovary after 5 hours.

Aminoglycosides↗
PubMed1982

[Treatment and prevention of infections with cefoxitin sodium in patients with biliary tract infections and obstructive jaundice].

UNLABELLED: A total of 24 patients who was hospitalized in the Internal Medicine Wards of Yamaguchi University attached Hospital and the university's 3 related hospitals were administered with cefoxitin. The breakdown of the patients treated with cefoxitin was 7 with cholecystitis, 7 with choledochitis and the remaining 10 for the prevention of infections with obstructive jaundice. Daily doses of 2-6 g of cefoxitin were administered for 6-40 days by intermittent intravenous drip infusion in divided doses. RESULTS: 1. Of 14 patients with biliary tract infections, 10 (71.4%) responded favorably with cefoxitin. 2. Of 10 patients with obstructive jaundice used for the prevention of infections, 8 (80%) responded favorably with cefoxitin. 3. No untoward side effects were observed. 4. Cefoxitin proved to be a safe and effective antibiotic in the treatment of biliary tract infections and for the prevention of infections in patients with obstructive jaundice.

Adult↗
PubMed1981

A circadian variation in the excretion of urinary kinin, kallikrein and prostaglandin E in normal volunteers.

The present study shows that there is a circadian variation in the excretion of urinary kinin, kallikrein and prostaglandin E (PGE) as well as urine flow, urinary sodium excretion and urinary potassium excretion in recumbent healthy volunteers. The present data, that the acrophase of urinary kallikrein excretion was 1.5 hr later than that of plasma aldosterone concentration (PAC) and that a significant positive correlation was found in circadian variations between urinary kallikrein and PAC, suggest that the circadian variation of urinary kallikrein excretion may be regulated by aldosterone. The pattern of circadian variation of average urinary kinin excretion coincided with those of average urine flow, urinary sodium excretion and urinary PGE excretion, suggesting that renal kinin and PGE may be involved in the regulation of water-sodium excretion. The present data that the phase of circadian variation of urinary kinin was delayed from that of urinary kallikrein and that there was a mirror image between the circadian variation in urinary kinin and kallikrein suggest that there may be a feedback mechanism in renal kallikrein-kinin system.

Adult↗
PubMed1981

Porosity--strength relationship in a Cu-rich spherical alloy amalgam.

Porosity and strength of spherical Cu-rich alloy amalgams were analyzed in the under-graduate materials laboratory. The minimum value for porosity was obtained for 46% initial Hg content, whereas the maximum strengths were obtained for 42% initial Hg. This result did not coincide with the data previously obtained for the conventional spherical alloy amalgam, in which the maximum strength and the minimum porosity were strictly associated with the optimum initial Hg content. Although no critical value for porosity could be definitely demonstrated by this effort, this result may be an indirect indication for 4.5 vol% porosity as the critical value.

Copper↗
PubMed1981

[Retention of three different luting cements (author's transl)].

Employing zinc phosphate, polycarboxylate and glass ionomer cements, effect of cement layer thickness on retention of crowns at their axial wall was investigated. Stainless steel preparations and occlusally perforated crowns having taper angles of 2.9 and 5.7 degrees were cemented, regulating the thickness at the axial wall from 5 to 60 mu. These dies were stored in a 100% relative humidity atmosphere at room temperature or in distilled water. After 48 hr, retention was measured, applying the load vertically to occlusal preparation surface through a plunger (Fig. 1). Due to the inclusion of unreacted powder particles in the set structure of all three cements, evidence of a critical value was always shown in the cement thickness-retention relationship (Figs. 2, 3 and 4). When the cement thickness was reduced below the critical value, the retention increased remarkably and was not affected by the environment. Above the critical value, however, the retention of these cements was relatively small and affected considerably by the environment. By water immersion, the increase in the retention was found for the two polyacrylate, but not for the zinc phosphate. Correlation between retention and mechanical strengths of the three cements in the respective environments was indefinite.

Adhesiveness↗