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Biomedical subjects

S Yoshimoto

Publications and source records attributed to S Yoshimoto.

At least 145 records · Page 8Linked to original sources
PubMed1982

Detection of type C virus particles in Japanese monkeys seropositive to adult T-cell leukemia-associated antigens.

Type C virus particles which were identical to adult T-cell leukemia virus (ATLV) in morphology were detected in phytohemagglutinin-stimulated peripheral lymphocytes from four out of four Japanese monkeys seropositive to adult T-cell leukemia-associated antigens. It is possible that non-human primates may be a natural reservoir of ATLV, and vector-borne transmission of ATLV from monkeys to humans should be explored.

Animals↗
PubMed1981

Chromosome 14q+ in adult T-cell leukemia.

Cytogenetic studies were performed on leukemic cells from two patients with adult T-cell leukemia. A 14q+ marker chromosome was found in the peripheral blood leukocytes from patient No. 1 and in a leukemic T-cell line (MT-1) derived from the peripheral blood of patient No. 2. The 14q+ resulted from a t(12;14) in patient No. 1 and from a t(Y;14) in patient No. 2 with a break point at 14q32 in each case. In addition, the leukemic cells from patient No. 1 showed a t(1;7) and a 9q-, while the MT-1 line had numerous structural abnormalities. Thus, it is clear that a 14q+ translocation is not restricted to B-cell neoplasms but occurs in T-cell neoplasms as well.

Adult↗
PubMed1981

Endoscopic retrograde pancreatic parenchymography.

Endoscopic retrograde pancreatic parenchymography was performed using the technique of endoscopic retrograde cholangiopancreatography. Contrast material was prepared from a nonionic surfactant combined with either sodium iothalamate or sodium and meglumine diatrizoate. With this method, a smooth contour of the pancreas and homogeneous pattern of the parenchyma were shown in the normal pancreas, while an irregular contour of the pancreas, unhomogeneous pattern of the parenchyma, and diminution of the area of the pancreas were found in chronic pancreatitis. In pancreatic carcinoma, a filling defect of the pancreatic field was seen. In the 186 cases studied, the only complication observed was a transient rise in serum amylase level.

Cholangiopancreatography, Endoscopic Retrograde↗
PubMed1981

A T-cell line derived from normal human cord leukocytes by co-culturing with human leukemic T-cells.

A unique T-cell line, MT-2, was established from normal human cord leukocytes of a male infant by co-culturing with leukemic T-cells from a female patient with adult T-cell leukemia. MT-2 cells expressed receptors for sheep erythrocytes and complement and were reactive with anti-T-cell and anti-Ia sera. They were negative for Fc receptors, surface immunoglobulin, and Epstein-Barr virus nuclear antigen. Chromosomally, the MT-2 line was male and most cells were shown to have a normal diploid karyotype. The cultured cells were tumorigenic when transplanted into immunosuppressed newborn hamsters.

Animals↗
PubMed1980

Impression method of the colon using sodium alginate--an experimental evaluation in dog.

An experimental study using adult dog was conducted on the impression of the colon whereby a screening test is done by making a mold of the intestine with sodium alginate. The mold of the intestine could be obtained easily and safely in a short time. Protrusions about 2 mm in diameter corresponding to lymphoid tissue of the rectum and sigmoid colon and shallow depressions on the surface of the protrusions were exactly imprinted on the surface of the mild. Compared with the barium study and endoscopy, this method requires neither special equipment nor high-grade technique, can be done easily in a short time and was not inferior in the diagnosis accuracy. Sodium alginate used in this method is a safe substance which is being used clinically as a plasma expander and laxative in addition to being used as an additive to various foods. When injected into the intestine, it exerted no injurious action whatsoever. from these findings, the possibility of this method being used clinically was considered high.

Alginates↗
PubMed1980

Development of impression method of the colon using sodium alginate--experimental evaluation by the use of intestinal phantom.

We devised an impression method of the colon using sodium alginate as a screening method for diseases of the lower part of the colon and evaluated its usefulness by means of an intestinal phantom. Sodium alginate, when mixed with water, kept enough fluidity immediately after mixing and could easily be poured into the phantom. With this paste gelatinized sharply in the phantom about two minutes after, an impression of the intestinal phantom could easily be made. Sodium alginate is a safe substance which is already used clinically. This method is thus expected to become popular as a screening method for diseases of the lower part of the colon.

Alginates↗
PubMed1980

Superiority of hemofiltration to hemodialysis for treatment of chronic renal failure: comparative studies between hemofiltration and hemodialysis on dialysis disequilibrium syndrome.

A significantly lower incidence of DDS, hypotension, and impending shock was found during and after hemofiltration as compared with conventional hemodialysis. Hemofiltration, in contrast to hemodialysis, showed less decrease of circulating plasma volume, mild change in plasma osmolality without red cell swelling, better compensation of acidosis despite less uptake of acetate, more stable PCO2 during the procedure, less paradoxical acidosis in cerebrospinal fluid, and a lower urea concentration gradient between cerebrospinal fluid and plasma. These phenomena might be explained by better mass transfer between compartments bithin the body during hemofiltration. Mass transfer from the intracellular as well as the extracellular space to circulating plasma occurred more rapidly and smoothly during HF than during HD. HF is preferable to HD in patients with severe cardiovascular complications such as hypertension, as well as hypotension and cardiac failure, and in those subject to DDS during HD. Accordingly, hemofiltration therapy promises patients more comfortable and more stable treatment of chronic uremia.

Acid-Base Equilibrium↗